EFSA
ecomole
vscht
  2. Sugar apple (as plant) // Annona squamosa L.

Sugar apple (as plant) // Annona squamosa L.

Family:
Annonaceae
Approval state:
Approved
Number of articles retrieved:
1751
Number of processed references:
12
Compositions
#1: glaucine in the roots and bark #2: camphor in the roots and bark #3: corydine in the roots and bark #4: anonaine in the roots and bark #5: isocorydine in the roots and bark #6: nornuciferine in the unripe fruits #7: anonaine in the unripe fruits #8: N-methylcoclaurine in the unripe fruits #9: coclaurine in the unripe fruits #10: reticuline in the unripe fruits #11: liriodenine in the unripe fruits #12: asimilobine in the unripe fruits #13: alkaloids: oxoaorphines: liriodenine (oxoushinsunine), in the unripe fruits #14: 4-deoxyannoreticuin, cis-4-deoxyannoreticuin, (2,4-cis and trans)-squamoxinone in bark #15: squamolinone, 9-oxo-asimicinone, bullacin B in bark #16: squamostolide in seeds #17: 1,8-cineole in the fruit (1.4%) #18: O-methylarmepavine in leaves #19: acetogenins in leaves #20: acetogenins (uvarigrandin A, squamostatin-A, squamostatin-D, annosquacin-I, annosquatin-I, annosquatin-II) in seeds #21: annonacinone, bullatacin in fruits #22: squamocin in fruits #23: annonacin in fruits #24: mosinone A, mosin B, mosin C, annoreticutin-9-one in bark
Endpoint Studies
#1: Toxicity existing in heart, liver and kidney after total ACG administered, which might result from the ATP level dropping and the concentrations of intracellular calcium and ROS rising by inhibiting the activity of complex I in rats #2: OECD 420, mortality, decreased body weight and food intake
Genotoxicity
#1: dose related increase in DNA migration. #2: induction in frequency of micronuclei #3: induction in frequency of chromosomal aberrations
Composition #1: Rao, R. V. Krishna., Murty, Narasimha., Rao, J. V. L. N. Seshagiri. Occurrence of borneol and camphor and a new terpene in Annona squamosa. indian journal of pharmaceutical sciences, 1978, vol. 40, no. 5, p. 170–1. .
Composition #2: Rao, R. V. Krishna., Murty, Narasimha., Rao, J. V. L. N. Seshagiri. Occurrence of borneol and camphor and a new terpene in Annona squamosa. indian journal of pharmaceutical sciences, 1978, vol. 40, no. 5, p. 170–1. .
Composition #3: Rao, R. V. Krishna., Murty, Narasimha., Rao, J. V. L. N. Seshagiri. Occurrence of borneol and camphor and a new terpene in Annona squamosa. indian journal of pharmaceutical sciences, 1978, vol. 40, no. 5, p. 170–1. .
Composition #4: Rao, R. V. Krishna., Murty, Narasimha., Rao, J. V. L. N. Seshagiri. Occurrence of borneol and camphor and a new terpene in Annona squamosa. indian journal of pharmaceutical sciences, 1978, vol. 40, no. 5, p. 170–1. .
Composition #5: Rao, R. V. Krishna., Murty, Narasimha., Rao, J. V. L. N. Seshagiri. Occurrence of borneol and camphor and a new terpene in Annona squamosa. indian journal of pharmaceutical sciences, 1978, vol. 40, no. 5, p. 170–1. .
Composition #6: Wu, Yang-Chang., Chang, Fang-Rong., Chen, Keh-Shaw., Ko, Feng-Nien., Teng, Che-Ming. Bioactive alkaloids from Annona squamosa. chinese pharmaceutical journal, 1994, vol. 46, no. 5, p. 438–446. .
Composition #7: Wu, Yang-Chang., Chang, Fang-Rong., Chen, Keh-Shaw., Ko, Feng-Nien., Teng, Che-Ming. Bioactive alkaloids from Annona squamosa. chinese pharmaceutical journal, 1994, vol. 46, no. 5, p. 438–446. .
Composition #8: Wu, Yang-Chang., Chang, Fang-Rong., Chen, Keh-Shaw., Ko, Feng-Nien., Teng, Che-Ming. Bioactive alkaloids from Annona squamosa. chinese pharmaceutical journal, 1994, vol. 46, no. 5, p. 438–446. .
Composition #9: Wu, Yang-Chang., Chang, Fang-Rong., Chen, Keh-Shaw., Ko, Feng-Nien., Teng, Che-Ming. Bioactive alkaloids from Annona squamosa. chinese pharmaceutical journal, 1994, vol. 46, no. 5, p. 438–446. .
Composition #10: Wu, Yang-Chang., Chang, Fang-Rong., Chen, Keh-Shaw., Ko, Feng-Nien., Teng, Che-Ming. Bioactive alkaloids from Annona squamosa. chinese pharmaceutical journal, 1994, vol. 46, no. 5, p. 438–446. .
Composition #11: Wu, Yang-Chang., Chang, Fang-Rong., Chen, Keh-Shaw., Ko, Feng-Nien., Teng, Che-Ming. Bioactive alkaloids from Annona squamosa. chinese pharmaceutical journal, 1994, vol. 46, no. 5, p. 438–446. .
Composition #12: Wu, Yang-Chang., Chang, Fang-Rong., Chen, Keh-Shaw., Ko, Feng-Nien., Teng, Che-Ming. Bioactive alkaloids from Annona squamosa. chinese pharmaceutical journal, 1994, vol. 46, no. 5, p. 438–446. .
Composition #13: Wu, Yang-Chang., Chang, Fang-Rong., Chen, Keh-Shaw., Ko, Feng-Nien., Teng, Che-Ming. Bioactive alkaloids from Annona squamosa. chinese pharmaceutical journal, 1994, vol. 46, no. 5, p. 438–446. .
Composition #14: Hopp, DC., Alali, FQ., Gu, ZM., McLaughlin, JL. Mono-THF ring annonaceous acetogenins from Annona squamosa. phytochemistry, 1998, vol. 47, no. 5, p. 803–809. DOI: 10.1016/S0031-9422(97)00822-4. [DOI link]
Composition #15: Hopp, DC., Alali, FQ., Gu, ZM., McLaughlin, JL. Three new bioactive bis-adjacent THF-ring acetogenins from the bark of Annona squamosa . bioorganic & medicinal chemistry, 1998, vol. 6, no. 5, p. 569–575. DOI: 10.1016/S0968-0896(98)00018-2. [DOI link]
Composition #16: Xie, HH., Wei, XY., Wang, JD., Liu, MF., Yang, RZ. A new cytotoxic acetogenin from the seeds of Annona squamosa. chinese chemical letters, 2003, vol. 14, no. 6, p. 588–590. .
Composition #17: Shashirekha, Mysore N., Baskaran, Revathy., Rao, Lingamallu Jaganmohan., Vijayalakshmi, Munusamy R., Rajarathnam, Somasundaram. Influence of processing conditions on flavour compounds of custard apple (Annona squamosa L.) . lwt-food science and technology, 2008, vol. 41, no. 2, p. 236–243. DOI: 10.1016/j.lwt.2007.03.005. [DOI link]
Composition #18: Vila-Nova, Nadja Soares., de Morais, Selen Maia., Cajazeiras Falcao, Maria Jose., Andrade Machado, Lyeghyna Karla., Leal Bevilaqua, Claudia Maria., Sousa Costa, Igor Rafael., Pompeu de Sousa Brasil, Nilce Viana Gramosa., de Andrade Junior, Heitor Franco. Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil . revista da sociedade brasileira de medicina tropical, 2011, vol. 44, no. 5, p. 567–571. DOI: 10.1590/S0037-86822011000500007. [DOI link]
Composition #19: Vila-Nova, Nadja Soares., de Morais, Selen Maia., Cajazeiras Falcao, Maria Jose., Andrade Machado, Lyeghyna Karla., Leal Bevilaqua, Claudia Maria., Sousa Costa, Igor Rafael., Pompeu de Sousa Brasil, Nilce Viana Gramosa., de Andrade Junior, Heitor Franco. Leishmanicidal activity and cytotoxicity of compounds from two Annonacea species cultivated in Northeastern Brazil . revista da sociedade brasileira de medicina tropical, 2011, vol. 44, no. 5, p. 567–571. DOI: 10.1590/S0037-86822011000500007. [DOI link]
Composition #20: Chen, Yong., Chen, Jian-wei., Li, Xiang. Cytotoxic Bistetrahydrofuran Annonaceous Acetogenins from the Seeds of Annona squamosa . journal of natural products, 2011, vol. 74, no. 11, p. 2477–2481. DOI: 10.1021/np200708q. [DOI link]
Composition #21: Bonneau, Natacha., Baloul, Lamia., Ndob, Idensi Bajin Ba., Senejoux, Francois., Champy, Pierre. The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis . food chemistry, 2017, vol. 226, p. 32–40. DOI: 10.1016/j.foodchem.2017.01.042. [DOI link]
Composition #22: Bonneau, Natacha., Baloul, Lamia., Ndob, Idensi Bajin Ba., Senejoux, Francois., Champy, Pierre. The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis . food chemistry, 2017, vol. 226, p. 32–40. DOI: 10.1016/j.foodchem.2017.01.042. [DOI link]
Composition #23: Bonneau, Natacha., Baloul, Lamia., Ndob, Idensi Bajin Ba., Senejoux, Francois., Champy, Pierre. The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis . food chemistry, 2017, vol. 226, p. 32–40. DOI: 10.1016/j.foodchem.2017.01.042. [DOI link]
Composition #24: Hopp, DC., Zeng, L., Gu, ZM., Kozlowski, JF., McLaughlin, JL. Novel mono-tetrahydrofuran ring acetogenins, from the bark of Annona squamosa, showing cytotoxic selectivities for the human pancreatic carcinoma cell line, PACA-2 . journal of natural products, 1997, vol. 60, no. 6, p. 581–586. DOI: 10.1021/np9701283. [DOI link]
Endpoint study #1: Wang Yu., Chen Yong., Qiu Hai-long., Miao Jun-jie., Chen Jian-wei., Li Xiang. Toxicity and mechanism of total annonaceous acetogenins on heart, liver and kidney of rats . zhongguo yaolixue yu dulixue zazhi, 2013, vol. 27, no. 3, p. 434–439. DOI: 10.3867/j.issn.1000-3002.2013.03.022. [DOI link]
Endpoint study #2: Grover, Paramjit., Singh, S. P., Prabhakar, P. V., Reddy, Utkarsh A., Balasubramanyam, A., Mahboob, M., Rahman, M. F., Misra, Sunil. In vivo assessment of genotoxic effects of Annona squamosa seed extract in rats . food and chemical toxicology, 2009, vol. 47, no. 8, p. 1964–1971. DOI: 10.1016/j.fct.2009.05.013. [DOI link]
Genotox #1: Grover, Paramjit., Singh, S. P., Prabhakar, P. V., Reddy, Utkarsh A., Balasubramanyam, A., Mahboob, M., Rahman, M. F., Misra, Sunil. In vivo assessment of genotoxic effects of Annona squamosa seed extract in rats . food and chemical toxicology, 2009, vol. 47, no. 8, p. 1964–1971. DOI: 10.1016/j.fct.2009.05.013. [DOI link]
Genotox #2: Grover, Paramjit., Singh, S. P., Prabhakar, P. V., Reddy, Utkarsh A., Balasubramanyam, A., Mahboob, M., Rahman, M. F., Misra, Sunil. In vivo assessment of genotoxic effects of Annona squamosa seed extract in rats . food and chemical toxicology, 2009, vol. 47, no. 8, p. 1964–1971. DOI: 10.1016/j.fct.2009.05.013. [DOI link]
Genotox #3: Grover, Paramjit., Singh, S. P., Prabhakar, P. V., Reddy, Utkarsh A., Balasubramanyam, A., Mahboob, M., Rahman, M. F., Misra, Sunil. In vivo assessment of genotoxic effects of Annona squamosa seed extract in rats . food and chemical toxicology, 2009, vol. 47, no. 8, p. 1964–1971. DOI: 10.1016/j.fct.2009.05.013. [DOI link]