EFSA Compendium of Botanicals

Draft - work in progress

Angelica sinensis (Oliv.) Diels // Angelica polymorpha var. sinensis Oliv.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 3285
Number of processed references:: 5

Compositions

#1: Bergapten in water extract #2: Bergapten in ethanol extract #3: Coniferyl Ferulate in roots #4: Butylidenephthalide in roots #5: Z-ligustilide in roots #6: ligustilide in radix #7: Z-ligustilide and E-ligustilide in roots

Endpoint Studies

#1: hypertension in humans

Genotoxicity

Composition #1: Lin, Y.-K., Sheu, M.-T., Huang, C.-H., Ho, H.-O. Development of a reversed-phase high-performance liquid Chromatographie method for analyzing furanocoμmarin components in citrus fruit juices and Chinese herbal medicines. journal of chromatographic science, 2009, vol. 47, no. 3, p. 211–215. DOI: 10.1093/chromsci/47.3.211. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water (herb)
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10.1
Internal remarks:

Bergapten in water extract

Composition #2: Lin, Y.-K., Sheu, M.-T., Huang, C.-H., Ho, H.-O. Development of a reversed-phase high-performance liquid Chromatographie method for analyzing furanocoμmarin components in citrus fruit juices and Chinese herbal medicines. journal of chromatographic science, 2009, vol. 47, no. 3, p. 211–215. DOI: 10.1093/chromsci/47.3.211. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol (herb)
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.1
Internal remarks:

Bergapten in ethanol extract

Composition #3: Zschocke, S., Liu, JH., Stuppner, H., Bauer, R. Comparative study of roots of Angelica sinensis and related umbelliferous drugs by thin layer chromatography, high-performance liquid chromatography, and liquid chromatography mass spectrometry. phytochemical analysis, 1998, vol. 9, no. 6, p. 283–290. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

n-hexane
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

Coniferyl Ferulate
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC and TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coniferyl Ferulate in roots

Composition #4: Zschocke, S., Liu, JH., Stuppner, H., Bauer, R. Comparative study of roots of Angelica sinensis and related umbelliferous drugs by thin layer chromatography, high-performance liquid chromatography, and liquid chromatography mass spectrometry. phytochemical analysis, 1998, vol. 9, no. 6, p. 283–290. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

n-hexane
Substance:

3-Butylidenephthalide 3-Butylidenephthalide (RF-00001798-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC and TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Butylidenephthalide in roots

Composition #5: Zschocke, S., Liu, JH., Stuppner, H., Bauer, R. Comparative study of roots of Angelica sinensis and related umbelliferous drugs by thin layer chromatography, high-performance liquid chromatography, and liquid chromatography mass spectrometry. phytochemical analysis, 1998, vol. 9, no. 6, p. 283–290. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

n-hexane
Substance:

Z-ligustilide (RF-00011188-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC and TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Z-ligustilide in roots

Composition #6: Long, Rui., Yang, Fang., Du, Jun-rong., Qian, Zhong-ming., Wang, Chen-yuan., Chen, Chu. Effects of Ligustilide on Tumor Growth and Immune Function in Institute of Cancer Research Mice. tropical journal of pharmaceutical research, 2012, vol. 11, no. 3, p. 421–428. DOI: 10.4314/tjpr.v11i3.11. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

supercritical-CO2 (radix)
Substance:

ligustilide (RF-00003900-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

electron impact ionisation MS, 1 H NMR and 13C NMR spectrometric techniques.
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

ligustilide in radix

Composition #7: Bunel, Valerian., Antoine, Marie-Helene., Nortier, Joelle., Duez, Pierre., Stevigny, Caroline. Nephroprotective effects of ferulic acid, Z-ligustilide and E-ligustilide isolated from Angelica sinensis against cisplatin toxicity in vitro. toxicology in vitro, 2015, vol. 29, no. 3, p. 458–467. DOI: 10.1016/j.tiv.2014.12.017. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

ligustilide (RF-00003900-PAR)
Additional substance description:

Z-ligustilide and E-ligustilide
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Z-ligustilide and E-ligustilide in roots

Endpoint study #1: Brown, Amy C. Heart Toxicity Related to Herbs and Dietary Supplements: Online Table of Case Reports. Part 4 of 5. journal of dietary supplements, 2018, vol. 15, no. 4, p. 516–555. DOI: 10.1080/19390211.2017.1356418. [DOI link]

Study relevance:

Human health
Substance:

Z-ligustilide (RF-00011188-PAR)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional plant/substance description:

unspecified
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male/Female
Number of organisms dosed:

2
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

Cardiovascular / Haematological (TT001A)
Effect description:

32-year-old female with hypertension (185/85 mm Hg); also in her infant (115/69 mm Hg possibly via breast milk)
Effect or parameter linked to the endpoint:

haematology (CHD023BE)
Internal remarks:

hypertension in humans