EFSA Compendium of Botanicals

Draft - work in progress

Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. (as plant) // Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav. // Angelica dahurica var. dahurica

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 1167
Number of processed references:: 6

Compositions

#1: Furanocoumarins (RF-00004381-PAR) in roots #2: Falcarindiol in roots #3: Oxypeucedanin hydrate in roots #4: Imperatorin in roots #5: Nodakenin in roots #6: Phellopterin in roots #7: Imperatorin in roots #8: Byakangelicol in roots #9: Cnidicin (furocoumarin) in roots #10: Oxypeucedanin in roots #11: Isoimperatorin in roots #12: Isoimperatorin in roots #13: Imperatorin in roots #14: Alloimperatorin (furocoumarin) in roots #15: Phellopterin in roots #16: Bergapten in roots #17: Imperatorin in roots #18: Isoimperatorin in roots #19: Oxypeucedanin in roots #20: Phellopterin in roots #21: Furocoumarins (byakangelicin) in roots #22: Bergapten in roots #23: Imperatorin in roots #24: Isoimperatorin in roots #25: Isopimpinellin in roots #26: Oxypeucedanin in roots #27: Psoralen in roots #28: Furocoumarins in roots

Endpoint Studies

Genotoxicity

#1: photosensibilization

Composition #1: Zhou, J., Ouedraogo, M., Qu, F., Duez, P. Potential genotoxicity of traditional Chinese medicinal plants and phytochemicals: An overview. phytotherapy research, 2013, vol. 27, no. 12, p. 1745–1755. DOI: 10.1002/ptr.4942. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Substance:

Furanocoumarins (RF-00004381-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furanocoumarins (RF-00004381-PAR) in roots

Composition #2: Choi, SY., Ahn, EM., Song, MC., Kim, DW., Kang, JH., Kwon, OS., Kang, TC., Baek, NI. In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica . phytotherapy research, 2005, vol. 19, no. 10, p. 839–845. DOI: 10.1002/ptr.1424. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and, ethyl acetate or butanol
Substance:

falcarindiol (RF-00003811-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.059
Internal remarks:

Falcarindiol in roots

Composition #3: Choi, SY., Ahn, EM., Song, MC., Kim, DW., Kang, JH., Kwon, OS., Kang, TC., Baek, NI. In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica . phytotherapy research, 2005, vol. 19, no. 10, p. 839–845. DOI: 10.1002/ptr.1424. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and, ethyl acetate or butanol
Substance:

oxypeucedanin hydrate (RF-00003969-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.060
Internal remarks:

Oxypeucedanin hydrate in roots

Composition #4: Choi, SY., Ahn, EM., Song, MC., Kim, DW., Kang, JH., Kwon, OS., Kang, TC., Baek, NI. In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica . phytotherapy research, 2005, vol. 19, no. 10, p. 839–845. DOI: 10.1002/ptr.1424. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and, ethyl acetate or butanol
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.025
Internal remarks:

Imperatorin in roots

Composition #5: Choi, SY., Ahn, EM., Song, MC., Kim, DW., Kang, JH., Kwon, OS., Kang, TC., Baek, NI. In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica . phytotherapy research, 2005, vol. 19, no. 10, p. 839–845. DOI: 10.1002/ptr.1424. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and, ethyl acetate or butanol
Substance:

Nodakenin (RF-00013330-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.002
Internal remarks:

Nodakenin in roots

Composition #6: Choi, SY., Ahn, EM., Song, MC., Kim, DW., Kang, JH., Kwon, OS., Kang, TC., Baek, NI. In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica . phytotherapy research, 2005, vol. 19, no. 10, p. 839–845. DOI: 10.1002/ptr.1424. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol and, ethyl acetate or butanol
Substance:

Phellopterin (RF-00003560-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.018
Internal remarks:

Phellopterin in roots

Composition #7: Kim, Young-Kyoon., Kim, Young Sup., Ryu, Shi Yong. Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines . phytotherapy research, 2007, vol. 21, no. 3, p. 288–290. DOI: 10.1002/ptr.2043. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectral properties
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Imperatorin in roots

Composition #8: Kim, Young-Kyoon., Kim, Young Sup., Ryu, Shi Yong. Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines . phytotherapy research, 2007, vol. 21, no. 3, p. 288–290. DOI: 10.1002/ptr.2043. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Byakangelicol (RF-00011117-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectral properties
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Byakangelicol in roots

Composition #9: Kim, Young-Kyoon., Kim, Young Sup., Ryu, Shi Yong. Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines . phytotherapy research, 2007, vol. 21, no. 3, p. 288–290. DOI: 10.1002/ptr.2043. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

cnidicin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectral properties
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cnidicin (furocoumarin) in roots

Composition #10: Kim, Young-Kyoon., Kim, Young Sup., Ryu, Shi Yong. Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines . phytotherapy research, 2007, vol. 21, no. 3, p. 288–290. DOI: 10.1002/ptr.2043. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

oxypeucedanin (RF-00003968-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectral properties
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Oxypeucedanin in roots

Composition #11: Kim, Young-Kyoon., Kim, Young Sup., Ryu, Shi Yong. Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines . phytotherapy research, 2007, vol. 21, no. 3, p. 288–290. DOI: 10.1002/ptr.2043. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

isoimperatorin (RF-00003880-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

spectral properties
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoimperatorin in roots

Composition #12: Chen, Qinhua., Li, Peng., He, Jing., Zhang, Zhuo., Liu, Jia. Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS . journal of separation science, 2008, vol. 31, no. 18, p. 3218–3224. DOI: 10.1002/jssc.200800325. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

ethanol and water
Substance:

isoimperatorin (RF-00003880-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.31-0.68
Internal remarks:

Isoimperatorin in roots

Composition #13: Chen, Qinhua., Li, Peng., He, Jing., Zhang, Zhuo., Liu, Jia. Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS . journal of separation science, 2008, vol. 31, no. 18, p. 3218–3224. DOI: 10.1002/jssc.200800325. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

ethanol and water
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.58-3.14
Internal remarks:

Imperatorin in roots

Composition #14: Chen, Qinhua., Li, Peng., He, Jing., Zhang, Zhuo., Liu, Jia. Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS . journal of separation science, 2008, vol. 31, no. 18, p. 3218–3224. DOI: 10.1002/jssc.200800325. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

ethanol and water
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

alloimperatorin
Analytical method code:

GC-MS (F046A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.54-1.59
Internal remarks:

Alloimperatorin (furocoumarin) in roots

Composition #15: Chen, Qinhua., Li, Peng., He, Jing., Zhang, Zhuo., Liu, Jia. Supercritical fluid extraction for identification and determination of volatile metabolites from Angelica dahurica by GC-MS . journal of separation science, 2008, vol. 31, no. 18, p. 3218–3224. DOI: 10.1002/jssc.200800325. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

ethanol and water
Substance:

Phellopterin (RF-00003560-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.15-0.34
Internal remarks:

Phellopterin in roots

Composition #16: Wu, Xiaoyi., Chao, Zhimao., Wang, Chun., Yu, Li. Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio . journal of chromatography a, 2015, vol. 1384, p. 107–114. DOI: 10.1016/j.chroma.2015.01.057. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bergapten in roots

Composition #17: Wu, Xiaoyi., Chao, Zhimao., Wang, Chun., Yu, Li. Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio . journal of chromatography a, 2015, vol. 1384, p. 107–114. DOI: 10.1016/j.chroma.2015.01.057. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Imperatorin in roots

Composition #18: Wu, Xiaoyi., Chao, Zhimao., Wang, Chun., Yu, Li. Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio . journal of chromatography a, 2015, vol. 1384, p. 107–114. DOI: 10.1016/j.chroma.2015.01.057. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

isoimperatorin (RF-00003880-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoimperatorin in roots

Composition #19: Wu, Xiaoyi., Chao, Zhimao., Wang, Chun., Yu, Li. Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio . journal of chromatography a, 2015, vol. 1384, p. 107–114. DOI: 10.1016/j.chroma.2015.01.057. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

oxypeucedanin (RF-00003968-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Oxypeucedanin in roots

Composition #20: Wu, Xiaoyi., Chao, Zhimao., Wang, Chun., Yu, Li. Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio . journal of chromatography a, 2015, vol. 1384, p. 107–114. DOI: 10.1016/j.chroma.2015.01.057. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

Phellopterin (RF-00003560-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phellopterin in roots

Composition #21: Wu, Xiaoyi., Chao, Zhimao., Wang, Chun., Yu, Li. Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio . journal of chromatography a, 2015, vol. 1384, p. 107–114. DOI: 10.1016/j.chroma.2015.01.057. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

Furanocoumarins (RF-00004381-PAR)
Additional substance description:

byakangelicin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furocoumarins (byakangelicin) in roots

Composition #22: Chen, Lin., Jian, Yang., Wei, Ning., Yuan, Mei., Zhuang, Xiaomei., Li, Hua. Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats . journal of separation science, 2015, vol. 38, no. 24, p. 4216–4224. DOI: 10.1002/jssc.201500840. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

LC-MS/MS (F027A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Bergapten in roots

Composition #23: Chen, Lin., Jian, Yang., Wei, Ning., Yuan, Mei., Zhuang, Xiaomei., Li, Hua. Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats . journal of separation science, 2015, vol. 38, no. 24, p. 4216–4224. DOI: 10.1002/jssc.201500840. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

imperatorin (RF-00003874-PAR)
Analytical method code:

LC-MS/MS (F027A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Imperatorin in roots

Composition #24: Chen, Lin., Jian, Yang., Wei, Ning., Yuan, Mei., Zhuang, Xiaomei., Li, Hua. Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats . journal of separation science, 2015, vol. 38, no. 24, p. 4216–4224. DOI: 10.1002/jssc.201500840. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

isoimperatorin (RF-00003880-PAR)
Analytical method code:

LC-MS/MS (F027A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoimperatorin in roots

Composition #25: Chen, Lin., Jian, Yang., Wei, Ning., Yuan, Mei., Zhuang, Xiaomei., Li, Hua. Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats . journal of separation science, 2015, vol. 38, no. 24, p. 4216–4224. DOI: 10.1002/jssc.201500840. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Isopimpinellin (RF-00003784-PAR)
Analytical method code:

LC-MS/MS (F027A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isopimpinellin in roots

Composition #26: Chen, Lin., Jian, Yang., Wei, Ning., Yuan, Mei., Zhuang, Xiaomei., Li, Hua. Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats . journal of separation science, 2015, vol. 38, no. 24, p. 4216–4224. DOI: 10.1002/jssc.201500840. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

oxypeucedanin (RF-00003968-PAR)
Analytical method code:

LC-MS/MS (F027A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Oxypeucedanin in roots

Composition #27: Chen, Lin., Jian, Yang., Wei, Ning., Yuan, Mei., Zhuang, Xiaomei., Li, Hua. Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats . journal of separation science, 2015, vol. 38, no. 24, p. 4216–4224. DOI: 10.1002/jssc.201500840. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

psoralen (RF-00004015-PAR)
Analytical method code:

LC-MS/MS (F027A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Psoralen in roots

Composition #28: Chen, Lin., Jian, Yang., Wei, Ning., Yuan, Mei., Zhuang, Xiaomei., Li, Hua. Separation and simultaneous quantification of nine furanocoumarins from Radix Angelicae dahuricae using liquid chromatography with tandem mass spectrometry for bioavailability determination in rats . journal of separation science, 2015, vol. 38, no. 24, p. 4216–4224. DOI: 10.1002/jssc.201500840. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Furanocoumarins (RF-00004381-PAR)
Analytical method code:

LC-MS/MS (F027A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furocoumarins in roots

Genotox #1: Zhou, J., Ouedraogo, M., Qu, F., Duez, P. Potential genotoxicity of traditional Chinese medicinal plants and phytochemicals: An overview. phytotherapy research, 2013, vol. 27, no. 12, p. 1745–1755. DOI: 10.1002/ptr.4942. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

other (CHD008TT)
Method type:

in vitro
Tested organism:

Other (A07XE)
Is genotoxic:

Positive
Remarks on genotox study:

photosensibilization
Internal remarks:

photosensibilization
Internal ID:

eid=2-s2.0-84890560153