Draft - work in progress
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- Dill (as plant) // Anethum graveolens L.
Dill (as plant) // Anethum graveolens L.
- Family:
- Apiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 1796
- Number of processed references:
- 13
Composition #1: Dranik, L. I., Prokopenko, A. P. Coumarins and acids from Anethum graveolens fruit. khimiya prirodnykh soedinenii, 1969, vol. 5, no. 5, p. 437. .
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-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol
-
Substance:
Bergapten (RF-00003837-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
bergapten in fruits
Composition #2: Dranik, L. I., Prokopenko, A. P. Coumarins and acids from Anethum graveolens fruit. khimiya prirodnykh soedinenii, 1969, vol. 5, no. 5, p. 437. .
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-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol
-
Substance:
scopoletin (RF-00004048-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Scopoletin in fruits
Composition #3: Dranik, L. I., Prokopenko, A. P. Coumarins and acids from Anethum graveolens fruit. khimiya prirodnykh soedinenii, 1969, vol. 5, no. 5, p. 437. .
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol
-
Substance:
Esculetin (RF-00003667-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
esculetin in fruits
Composition #4: Dranik, L. I., Prokopenko, A. P. Coumarins and acids from Anethum graveolens fruit. khimiya prirodnykh soedinenii, 1969, vol. 5, no. 5, p. 437. .
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol
-
Substance:
umbelliferone (RF-00004096-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
Umbelliferone in fruits
Composition #5: Dranik, L. I., Prokopenko, A. P. Coumarins and acids from Anethum graveolens fruit. khimiya prirodnykh soedinenii, 1969, vol. 5, no. 5, p. 437. .
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
Ethanol
-
Substance:
umbelliprenin (RF-00003616-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
umbelliprenin in fruits
Composition #6: Baslas, B. K., Baslas, R. K. Chemistry of the oil from the herb Anethum graveolens. riechstoffe, aromen, koerperpflegemittel, 1972, vol. 22, no. 5), 155-, p. 158. .
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-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Substance:
Dillapiole (RF-00004277-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.02-6.30
-
Internal remarks:
Dillapiole in seeds
Composition #7: Baslas, B. K., Baslas, R. K. Chemistry of the oil from the herb Anethum graveolens. riechstoffe, aromen, koerperpflegemittel, 1972, vol. 22, no. 5), 155-, p. 158. .
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-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Substance:
Carvone (RF-0538-001-PPP)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
36.53-81.15
-
Internal remarks:
Carvone in seeds
Composition #8: Mahran, G.H., Kadry, H.A., Thabet, C.K., El-Olemy, M.M., Al-Azizi, M.M., Schiff, P.L., Wong, L.K., Liv, N. GC/MS analysis of volatile oil of fruits of anethum graveolens. pharmaceutical biology, 1992, vol. 30, no. 2, p. 139–144. DOI: 10.3109/13880209209053978.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Additional extraction description:
distillation
-
Substance:
Dihydrocarvone (RF-00011286-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.3-2.1
-
Internal remarks:
cis-dihydrocarvone and trans-dihydrocarvone in fruits
Composition #9: Mahran, G.H., Kadry, H.A., Thabet, C.K., El-Olemy, M.M., Al-Azizi, M.M., Schiff, P.L., Wong, L.K., Liv, N. GC/MS analysis of volatile oil of fruits of anethum graveolens. pharmaceutical biology, 1992, vol. 30, no. 2, p. 139–144. DOI: 10.3109/13880209209053978.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Additional extraction description:
distillation
-
Substance:
Carvone (RF-0538-001-PPP)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
22
-
Internal remarks:
carvone in fruits
Composition #10: Mahran, G.H., Kadry, H.A., Thabet, C.K., El-Olemy, M.M., Al-Azizi, M.M., Schiff, P.L., Wong, L.K., Liv, N. GC/MS analysis of volatile oil of fruits of anethum graveolens. pharmaceutical biology, 1992, vol. 30, no. 2, p. 139–144. DOI: 10.3109/13880209209053978.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Additional extraction description:
distillation
-
Substance:
l-Piperitone (RF-00007699-PAR)
-
Additional substance description:
piperitone
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
8.2
-
Internal remarks:
piperitone in fruits
Composition #11: Mahran, G.H., Kadry, H.A., Thabet, C.K., El-Olemy, M.M., Al-Azizi, M.M., Schiff, P.L., Wong, L.K., Liv, N. GC/MS analysis of volatile oil of fruits of anethum graveolens. pharmaceutical biology, 1992, vol. 30, no. 2, p. 139–144. DOI: 10.3109/13880209209053978.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Additional extraction description:
distillation
-
Substance:
myristicin (RF-00003941-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
3.2
-
Internal remarks:
myristicin in fruits
Composition #12: Mahran, G.H., Kadry, H.A., Thabet, C.K., El-Olemy, M.M., Al-Azizi, M.M., Schiff, P.L., Wong, L.K., Liv, N. GC/MS analysis of volatile oil of fruits of anethum graveolens. pharmaceutical biology, 1992, vol. 30, no. 2, p. 139–144. DOI: 10.3109/13880209209053978.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Additional extraction description:
distillation
-
Substance:
Dillapiole (RF-00004277-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
26.8
-
Internal remarks:
dillapiole in fruits
Composition #13: Alam, P., Alqasoumi, S.I., Abdel-Kader, S.M.S., Abdel-Kader, M.S. Densitometric HPTLC methods for qualitative and quantitative analysis of carvone, dillapiole, methylparaben and propylparaben in dill, caraway seeds and pharmaceutical formulations utilizing normal and reversed-phase silica gel plates. fabad journal of pharmaceutical sciences, 2013, vol. 38, no. 1, p. 33–48. .
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Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
acetone
-
Substance:
Carvone (RF-0538-001-PPP)
-
Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
-
Result unit:
Nanogram/gram (G076A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
7.07
-
Internal remarks:
carvone in seeds
Composition #14: Alam, P., Alqasoumi, S.I., Abdel-Kader, S.M.S., Abdel-Kader, M.S. Densitometric HPTLC methods for qualitative and quantitative analysis of carvone, dillapiole, methylparaben and propylparaben in dill, caraway seeds and pharmaceutical formulations utilizing normal and reversed-phase silica gel plates. fabad journal of pharmaceutical sciences, 2013, vol. 38, no. 1, p. 33–48. .
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
acetone
-
Substance:
Dillapiole (RF-00004277-PAR)
-
Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
-
Result unit:
Nanogram/gram (G076A)
-
Result expression:
Reconstituted product (B007A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
5.87
-
Internal remarks:
dillapiole in seeds
Composition #15: Ojala, T., Vuorela, P., Kiviranta, J., Vuorela, H., Hiltunen, R. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins . planta medica, 1999, vol. 65, no. 8, p. 715–718. DOI: 10.1055/s-1999-14049.
[
DOI link]
-
-
Plant part:
Leaves (as part-nature) (A0EKT)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
coumarins (RF-00004351-PAR)
-
Additional substance description:
Total coumarins depending on flowering stage
-
Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
-
Result unit:
Microgram/millilitre (G052A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.3-9.5
-
Internal remarks:
Total coumarins in leaves
Composition #16: Lazutka, JR., Mierauskiene, J., Slapsyte, G., Dedonyte, V. Genotoxicity of dill (Anethum graveolens L.), peppermint (Mentha x piperita L.) and pine (Pinus sylvestris L.) essential oils in human lymphocytes and Drosophila melanogaster . food and chemical toxicology, 2001, vol. 39, no. 5, p. 485–492. DOI: 10.1016/S0278-6915(00)00157-5.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Additional extraction description:
hydrodistillation
-
Substance:
Carvone (RF-0538-001-PPP)
-
Additional substance description:
commercial essential oil
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
58.11
-
Internal remarks:
Carvone (seeds)
Composition #17: Lazutka, JR., Mierauskiene, J., Slapsyte, G., Dedonyte, V. Genotoxicity of dill (Anethum graveolens L.), peppermint (Mentha x piperita L.) and pine (Pinus sylvestris L.) essential oils in human lymphocytes and Drosophila melanogaster . food and chemical toxicology, 2001, vol. 39, no. 5, p. 485–492. DOI: 10.1016/S0278-6915(00)00157-5.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Additional extraction description:
hydrodistillation
-
Substance:
Carvone (RF-0538-001-PPP)
-
Additional substance description:
commercial essential oil
-
Analytical method code:
Unspecified (F598A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
6.66
-
Internal remarks:
Carvone (aerial parts)
Composition #18: Wang, XS., Kapoor, V., Smythe, GA. Extraction and chromatography-mass spectrometric analysis of the active principles from selected Chinese herbs and other medicinal plants . american journal of chinese medicine, 2003, vol. 31, no. 6, p. 927–944. DOI: 10.1142/S0192415X0300165X.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
hexane
-
Substance:
Carvone (RF-0538-001-PPP)
-
Additional substance description:
various extraction techniques
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
45.84-48.15
-
Internal remarks:
carvone in seeds
Composition #19: Dhalwal, Kamlesh., Shinde, Vaibhav M., Mahadik, Kakasaheb R. Efficient and sensitive method for quantitative determination and validation of umbelliferone, carvone and myristicin in Anethum graveolens and Carum carvi seed . chromatographia, 2008, vol. 67, no. 1-2, p. 163–167. DOI: 10.1365/s10337-007-0473-6.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
myristicin (RF-00003941-PAR)
-
Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.015-0.042
-
Internal remarks:
myristicin in seeds
Composition #20: Dhalwal, Kamlesh., Shinde, Vaibhav M., Mahadik, Kakasaheb R. Efficient and sensitive method for quantitative determination and validation of umbelliferone, carvone and myristicin in Anethum graveolens and Carum carvi seed . chromatographia, 2008, vol. 67, no. 1-2, p. 163–167. DOI: 10.1365/s10337-007-0473-6.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
Carvone (RF-0538-001-PPP)
-
Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.032-0.072
-
Internal remarks:
carvone in seeds
Composition #21: Dhalwal, Kamlesh., Shinde, Vaibhav M., Mahadik, Kakasaheb R. Efficient and sensitive method for quantitative determination and validation of umbelliferone, carvone and myristicin in Anethum graveolens and Carum carvi seed . chromatographia, 2008, vol. 67, no. 1-2, p. 163–167. DOI: 10.1365/s10337-007-0473-6.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
umbelliferone (RF-00004096-PAR)
-
Analytical method code:
Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
-
Result unit:
Percent (G138A)
-
Result expression:
Dry matter (B002A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
0.002-0.007
-
Internal remarks:
umbelliferone in seeds
Composition #22: Ortan, Alina., Popescu, Maria-Lidia., Gaita, Andreea-Liana., Dinu-Pirvu, Cristina., Campeanu, Gh. Contributions to the Pharmacognostical Study on Anethum graveolens, Dill (Apiaceae) . romanian biotechnological letters, 2009, vol. 14, no. 2, p. 4342–4348. .
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-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethyl ether, methanol, water
-
Substance:
scopoletin (RF-00004048-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
scopoletin in aerial parts
Composition #23: Sousa, Rose Marie O. F., Rosa, Jose S., Oliveira, Luisa., Cunha, Ana., Fernandes-Ferreira, Manuel. Activities of Apiaceae essential oils and volatile compounds on hatchability, development, reproduction and nutrition of Pseudaletia unipuncta (Lepidoptera: Noctuidae) . industrial crops and products, 2015, vol. 63, p. 226–237. DOI: 10.1016/j.indcrop.2014.09.052.
[
DOI link]
-
-
Plant part:
Fruit unspecified (as part-nature) (A067D)
-
Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
-
Additional extraction description:
hydrostillation
-
Substance:
Carvone (RF-0538-001-PPP)
-
Additional substance description:
S-carvone in unripe fruits
-
Analytical method code:
GC-MS (F046A)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
66.6
-
Internal remarks:
S-Carvone
Composition #24: Amanpour, Asghar., Kelebek, Hasim., Selli, Serkan. Aroma constituents of shade-dried aerial parts of Iranian dill (Anethum graveolens L.) and savory (Satureja sahendica Bornm.) by solvent-assisted flavor evaporation technique . journal of food measurement and characterization, 2017, vol. 11, no. 3, p. 1430–1439. DOI: 10.1007/s11694-017-9522-5.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
dichloromethane
-
Substance:
Carvone (RF-0538-001-PPP)
-
Analytical method code:
GC-MS (F046A)
-
Analytical method - additional description:
GC (FID)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
16.2
-
Internal remarks:
Carvone in aerial parts
Composition #25: Amanpour, Asghar., Kelebek, Hasim., Selli, Serkan. Aroma constituents of shade-dried aerial parts of Iranian dill (Anethum graveolens L.) and savory (Satureja sahendica Bornm.) by solvent-assisted flavor evaporation technique . journal of food measurement and characterization, 2017, vol. 11, no. 3, p. 1430–1439. DOI: 10.1007/s11694-017-9522-5.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
dichloromethane
-
Substance:
Dihydrocarvone (RF-00011286-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Analytical method - additional description:
GC (FID)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.03
-
Internal remarks:
Dihydrocarvone in aerial parts
Composition #26: Amanpour, Asghar., Kelebek, Hasim., Selli, Serkan. Aroma constituents of shade-dried aerial parts of Iranian dill (Anethum graveolens L.) and savory (Satureja sahendica Bornm.) by solvent-assisted flavor evaporation technique . journal of food measurement and characterization, 2017, vol. 11, no. 3, p. 1430–1439. DOI: 10.1007/s11694-017-9522-5.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
dichloromethane
-
Substance:
Dillapiole (RF-00004277-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Analytical method - additional description:
GC (FID)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
6.66
-
Internal remarks:
Dillapiole in aerial parts
Composition #27: Amanpour, Asghar., Kelebek, Hasim., Selli, Serkan. Aroma constituents of shade-dried aerial parts of Iranian dill (Anethum graveolens L.) and savory (Satureja sahendica Bornm.) by solvent-assisted flavor evaporation technique . journal of food measurement and characterization, 2017, vol. 11, no. 3, p. 1430–1439. DOI: 10.1007/s11694-017-9522-5.
[
DOI link]
-
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
dichloromethane
-
Substance:
(+)-pulegone (RF-00003398-PAR)
-
Analytical method code:
GC-MS (F046A)
-
Analytical method - additional description:
GC (FID)
-
Result unit:
Percent (G138A)
-
Result type:
Numerical Value (VAL)
-
Value (concentration, content):
6.67
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Internal remarks:
Pulegone in aerial parts
Endpoint study
#1: Malihezaman, Monsefi., Mojaba, Masoudi., Elham, Hosseini., Farnaz, Gramifar., Ramin, Miri. ANTI-FERTILITY EFFECTS OF DIFFERENT FRACTIONS OF ANETHUM GRAVEOLENS L. EXTRACTS ON FEMALE RATS . african journal of traditional complementary and alternative medicines, 2012, vol. 9, no. 3, p. 336–341. DOI: 10.4314/ajtcam.v9i3.6.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
ethanol 80%, water
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Type of toxicological test:
reproduction toxicity (CHD009TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Strain of test organism:
Wistar (CHD013ST)
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Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
6
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Control groups used:
yes, concurrent vehicle
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Gram/kilogram (G015A)
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Effect concentration:
0.5
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Critical effect:
REPRODUCTIVE (TOX05A)
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Target tissue:
Urogenital (TT006A)
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Effect description:
hormonal level reduction (estradiol), diestrus phase prolongation, infertility, increase in pregnancy duration
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Effect or parameter linked to the endpoint:
reproduction (CHD014BE)
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Internal remarks:
hormonal level reduction (estradiol), diestrus phase prolongation, infertility, increase in pregnancy duration
Genotox #1: Lazutka, JR., Mierauskiene, J., Slapsyte, G., Dedonyte, V. Genotoxicity of dill (Anethum graveolens L.), peppermint (Mentha x piperita L.) and pine (Pinus sylvestris L.) essential oils in human lymphocytes and Drosophila melanogaster . food and chemical toxicology, 2001, vol. 39, no. 5, p. 485–492. DOI: 10.1016/S0278-6915(00)00157-5.
[
DOI link]
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Study category:
Genotoxicity
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Type of toxicological test:
somatic mutation assay in Drosophila (CHD045TT)
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Tested organism:
Drosophila melanogaster (as animal) (A0CMC)
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Exposure duration for in vivo:
48.0
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Unit of exposure duration:
Hour (G099A)
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Remarks on genotox study:
Dill herb essential oil induced somatic mutation with a peak response at concentrations of 0.25 and 0.75%
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Internal remarks:
Dill herb; SMART, mutagenic activity with a peak response at concentrations of 0.25 and 0.75%
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Internal ID:
WOS:000168638600009
Genotox #2: Abudayyak, Mahmoud., Ozdemir Nath, Ebru., Ozhan, Gul. Toxic potentials of ten herbs commonly used for aphrodisiac effect in Turkey . turkish journal of medical sciences, 2015, vol. 45, no. 3, p. 496–506. DOI: 10.3906/sag-1401-153.
[
DOI link]
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Study category:
Mutagenicity
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Type of toxicological test:
bacterial reverse mutation assay (CHD028TT)
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Guideline used:
No guideline followed
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Tested organism:
Bacteria (as organism) (A0CJR)
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Strain of test organism:
TA 98 (CHD029ST)
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Exogenous metabolic activation applied:
with and without
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Control groups used:
yes, concurrent vehicle
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Endpoint measured:
gene mutation
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Remarks on genotox study:
extracts exhibited mutagenic activities only with the TA98 strain at the studied concentrations 0.78-25 mg/mL
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Internal remarks:
AMES, mutagenic activities in concentration 0.78-25 mg/mL
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Internal ID:
WOS:000356357800005