EFSA Compendium of Botanicals

Draft - work in progress

Anagyris foetida L.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 93
Number of processed references:: 5

Compositions

#1: Retamine, sparteine, anagyrine and cytisine in green branches #2: Scopoletin, isoscopoletin, and 5-hydroxy-7-methoxycoumarin #3: N-methylcytisine in leaves and stems #4: cytisine in leaves and stems #5: lupanine in leaves and stems #6: 5,6-dehydrolupanine, anagyrine and rhombifoline in leaves and stems #7: sparteine in leaves and stems #8: Alkaloid: baptifoline in leaves #9: Alkaloid: anagyrine in leaves

Endpoint Studies

#1: dizzines, abdominal inflammation

Genotoxicity

Composition #1: Adzet, T., Batllori, L., San Martin, R. Alkaloids of some Genisteae species of Catalonia (Spain). plantes medicinales et phytotherapie, 1970, vol. 4, no. 1, p. 21–3. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Retamine, sparteine, anagyrine and cytisine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Retamine, sparteine, anagyrine and cytisine in green branches

Composition #2: El-Beih, F. K. A. Constituents of local plants. XVII. The coumarin constituents of Anagyris foetida L. herba hungarica, 1984, vol. 23(1-2), p. 127–30. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

scopoletin (RF-00004048-PAR)
Additional substance description:

Scopoletin, isoscopoletin, and 5-hydroxy-7-methoxycoumarin
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Scopoletin, isoscopoletin, and 5-hydroxy-7-methoxycoumarin

Composition #3: Al-Azizi, M. M., Al-Said, M. S., El-Olemy, M. M., Sattar, E. Abdel., Khalifa, A. S. Rhombifoline and 5,6-dehydrolupanine from Anagyrus foetida L.. archives of pharmacal research, 1994, vol. 17, no. 6, p. 393–7. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

N-Methylcytisine (RF-00003492-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

N-methylcytisine in leaves and stems

Composition #4: Al-Azizi, M. M., Al-Said, M. S., El-Olemy, M. M., Sattar, E. Abdel., Khalifa, A. S. Rhombifoline and 5,6-dehydrolupanine from Anagyrus foetida L.. archives of pharmacal research, 1994, vol. 17, no. 6, p. 393–7. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Cytisine (RF-00003762-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cytisine in leaves and stems

Composition #5: Al-Azizi, M. M., Al-Said, M. S., El-Olemy, M. M., Sattar, E. Abdel., Khalifa, A. S. Rhombifoline and 5,6-dehydrolupanine from Anagyrus foetida L.. archives of pharmacal research, 1994, vol. 17, no. 6, p. 393–7. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Lupanine (RF-00003910-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lupanine in leaves and stems

Composition #6: Al-Azizi, M. M., Al-Said, M. S., El-Olemy, M. M., Sattar, E. Abdel., Khalifa, A. S. Rhombifoline and 5,6-dehydrolupanine from Anagyrus foetida L.. archives of pharmacal research, 1994, vol. 17, no. 6, p. 393–7. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Quinolizidine alkaloids (RF-00004327-PAR)
Additional substance description:

5,6-dehydrolupanine, rhombifoline, anagyrine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

5,6-dehydrolupanine, anagyrine and rhombifoline in leaves and stems

Composition #7: Al-Azizi, M. M., Al-Said, M. S., El-Olemy, M. M., Sattar, E. Abdel., Khalifa, A. S. Rhombifoline and 5,6-dehydrolupanine from Anagyrus foetida L.. archives of pharmacal research, 1994, vol. 17, no. 6, p. 393–7. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

(-)-Sparteine (RF-00004059-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

UV, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sparteine in leaves and stems

Composition #8: Innocenti, G., Dall'Acqua, S., Viola, G., Loi, M. C. Cytotoxic constituents from Anagyris foetida leaves. fitoterapia, 2006, vol. 77, no. 7-8, p. 595–597. DOI: 10.1016/j.fitote.2006.06.012. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

baptifoline (RF-00004172-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

TLC, HPLC-DAD
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloid: baptifoline in leaves

Composition #9: Innocenti, G., Dall'Acqua, S., Viola, G., Loi, M. C. Cytotoxic constituents from Anagyris foetida leaves. fitoterapia, 2006, vol. 77, no. 7-8, p. 595–597. DOI: 10.1016/j.fitote.2006.06.012. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Anagyrine (RF-00004802-PAR)
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

TLC, HPLC-DAD
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloid: anagyrine in leaves

Endpoint study #1: Al-Qura'n, S. Ethnobotanical survey of folk toxic plants in southern part of Jordan. toxicon, 2005, vol. 46, no. 2, p. 119–129. DOI: 10.1016/j.toxicon.2005.04.010. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

No data
Number of organisms dosed:

20
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

dizzines, abdominal inflammation
Effect or parameter linked to the endpoint:

no data (CHD002BE)
Internal remarks:

dizzines, abdominal inflammation