EFSA Compendium of Botanicals

Draft - work in progress

Albizia julibrissin Durazz.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 997
Number of processed references:: 6

Compositions

#1: scopoletin in flower #2: formononetin in flower #3: lariciresinol in flower #4: gallic acid in flower #5: daidzein in stem bark #6: syringaresinol in stem bark #7: julibroside in stem bark #8: saponins in bark

Endpoint Studies

#1: Toxicity on respiratory system in mice (apoptosis in bronchial epithelium, oxidative injury of lung and inflammation). #2: nephrotoxicity of saponin - mechanism of apoptosis of kidney in mice #3: reproductive toxicity in female mice (Decrease gestation pregnancy. Ovary degeneration, Uterus hyperemia and edema) #4: hepatoxicity in female mice

Genotoxicity

Composition #1: Rong, Guang-Qing., Geng, Chang-An., Ma, Yun-Bao., Huang, Xiao-Yan., Wang, Hong-Ling., Zhao, Yong., Zhang, Xue-Mei., Chen, Ji-Jun. Chemical constituents from ethyl acetate extract of flower of Albizia julibrissin . . zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2014, vol. 39, no. 10, p. 1845–51. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

scopoletin (RF-00004048-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin in flower

Composition #2: Rong, Guang-Qing., Geng, Chang-An., Ma, Yun-Bao., Huang, Xiao-Yan., Wang, Hong-Ling., Zhao, Yong., Zhang, Xue-Mei., Chen, Ji-Jun. Chemical constituents from ethyl acetate extract of flower of Albizia julibrissin . . zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2014, vol. 39, no. 10, p. 1845–51. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

formononetin (RF-00000291-NTR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

formononetin in flower

Composition #3: Rong, Guang-Qing., Geng, Chang-An., Ma, Yun-Bao., Huang, Xiao-Yan., Wang, Hong-Ling., Zhao, Yong., Zhang, Xue-Mei., Chen, Ji-Jun. Chemical constituents from ethyl acetate extract of flower of Albizia julibrissin . . zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2014, vol. 39, no. 10, p. 1845–51. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

lariciresinol (RF-00011086-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lariciresinol in flower

Composition #4: Rong, Guang-Qing., Geng, Chang-An., Ma, Yun-Bao., Huang, Xiao-Yan., Wang, Hong-Ling., Zhao, Yong., Zhang, Xue-Mei., Chen, Ji-Jun. Chemical constituents from ethyl acetate extract of flower of Albizia julibrissin . . zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica, 2014, vol. 39, no. 10, p. 1845–51. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate
Substance:

gallic acid (RF-00003821-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

gallic acid in flower

Composition #5: Jung, MJ., Kang, SS., Jung, HA., Kim, GJ., Choi, JS. Isolation of flavonoids and a cerebroside from the stem bark of Aibizzia julibrissin . archives of pharmacal research, 2004, vol. 27, no. 6, p. 593–599. DOI: 10.1007/BF02980155. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol (stem bark)
Substance:

daidzein (RF-00000061-NTR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

daidzein in stem bark

Composition #6: Jung, MJ., Kang, SS., Jung, HA., Kim, GJ., Choi, JS. Isolation of flavonoids and a cerebroside from the stem bark of Aibizzia julibrissin . archives of pharmacal research, 2004, vol. 27, no. 6, p. 593–599. DOI: 10.1007/BF02980155. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol (stem bark)
Substance:

syringaresinol (RF-00011386-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

syringaresinol in stem bark

Composition #7: Hua, Hui., Feng, Lei., Zhang, Xiao-ping., Zhang, Lian-fen., Jin, Jian. Anti-angiogenic activity of julibroside J(8), a natural product isolated from Albizia julibrissin . phytomedicine, 2009, vol. 16, no. 8, p. 703–711. DOI: 10.1016/j.phymed.2009.01.002. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol (stem bark)
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

julibroside
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

julibroside in stem bark

Composition #8: Shu Yang., Cao Mei., Yin Zhong-Qiong., Li Ping., Li Tai-Qiang., Long Xing-Fa., Zhu Lian-Fa., Jia Ren-Yong., Dai Shu-Jun., Zhao Jian. The reproductive toxicity of saponins isolated from Cortex Albiziae in female mice . chinese journal of natural medicines, 2015, vol. 13, no. 2, p. 119–126. DOI: 10.3724/SP.J.1009.2015.00119. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins in bark

Endpoint study #1: Kang, Xiaoxing., Gao, Yueying., Yu, Xingyun., Feng, Lei., Chen, Shuang., Qiu, Liying., Jin, Jian. Toxicity and mechanism of total saponin from bark of Albizia julibrissin on respiratory system in mice. zhongyaocai, 2011, vol. 34, no. 3, p. 428–431. .

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Bark (as part-nature) (A066X)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

No data
Route of exposure:

ORAL: CAPSULE (OECD2228PL)
Exposure duration:

15.0
Unit of exposure duration:

Day (G134A)
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

7.5
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

respiratory: Lung (TT041A)
Effect description:

toxicity on respiratory system are apoptosis in bronchial epithelium, oxidative injury of lung and inflammation.
Effect or parameter linked to the endpoint:

immunology (CHD026BE)
Internal remarks:

Toxicity on respiratory system in mice (apoptosis in bronchial epithelium, oxidative injury of lung and inflammation).

Endpoint study #2: Qiu, Liying., Li, Qian., Xu, Tianchan., Liu, Lingyan., Feng, Lei., Jin, Jian., Wu, Pengxi. Study of nephrotoxicity and its mechanism of saponin from Albizia julibrissin durazz in mice. dulixue zazhi, 2011, vol. 25, no. 6, p. 431–434. .

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

No data
Route of exposure:

OTHER (OECD0PL)
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

nephrotoxicity of saponin - mechanism of apoptosis of kidney
Effect or parameter linked to the endpoint:

immunology (CHD026BE)
Internal remarks:

nephrotoxicity of saponin - mechanism of apoptosis of kidney in mice

Endpoint study #3: Shu Yang., Cao Mei., Yin Zhong-Qiong., Li Ping., Li Tai-Qiang., Long Xing-Fa., Zhu Lian-Fa., Jia Ren-Yong., Dai Shu-Jun., Zhao Jian. The reproductive toxicity of saponins isolated from Cortex Albiziae in female mice . chinese journal of natural medicines, 2015, vol. 13, no. 2, p. 119–126. DOI: 10.3724/SP.J.1009.2015.00119. [DOI link]

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water
Type of toxicological test:

reproduction toxicity (CHD009TT)
Limit test:

Yes
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

19.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

80
Control groups used:

yes, concurrent no treatment
Endpoint measured:

Lowest observed adverse effect level (CHD026EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

540
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

Pregnancy rate decreased by 70% within the group receiving 540 mg·kg−1·d−1. The rates of implantation in the early, middle, and late pregnancy were all decreased, with stillbirths and maternal deaths being observed.
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

reproductive toxicity in female mice (Decrease gestation pregnancy. Ovary degeneration, Uterus hyperemia and edema)

Endpoint study #4: Shu Yang., Cao Mei., Yin Zhong-Qiong., Li Ping., Li Tai-Qiang., Long Xing-Fa., Zhu Lian-Fa., Jia Ren-Yong., Dai Shu-Jun., Zhao Jian. The reproductive toxicity of saponins isolated from Cortex Albiziae in female mice . chinese journal of natural medicines, 2015, vol. 13, no. 2, p. 119–126. DOI: 10.3724/SP.J.1009.2015.00119. [DOI link]

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water
Type of toxicological test:

reproduction toxicity (CHD009TT)
Limit test:

Yes
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

19.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

80
Control groups used:

yes, concurrent no treatment
Endpoint measured:

Lowest observed adverse effect level (CHD026EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

540
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

SCA may induce metabolic abnormalities in the liver, but the level of abnormality in the present study remained in a relatively safe range. The dosage of 540 mg·kg–1·d–1used in our subsequent studies showed a certain degree of reliability
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

hepatoxicity in female mice