Draft - work in progress
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- Agrostemma githago L.
Agrostemma githago L.
- Family:
- Caryophyllaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 429
- Number of processed references:
- 6
Composition #1: Ratsimamanga, Buu-Hoi, A. R., Janicaud, J. Some physiological properties of githagin.. comptes rendus des seances de la societe de biologie et de ses filiales, 1944, vol. 138, p. 486–8. .
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Plant part:
Seed (as part-nature) (A066P)
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Substance:
githagin (RF-00003407-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
githagin in seeds
Composition #2: Poisonous substances obtained from seed oil of corn cockle.. zzz, 1956, vol. 6, p. 285–93. .
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Plant part:
Seed (as part-nature) (A066P)
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Substance:
githagin (RF-00003407-PAR)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
githagin in seeds
Composition #3: Kotz, J. Morphology and pathogenesis of corn cockle (Agrostemma githago) poisoning in poultry. II. Own investigations.. medycyna weterynaryjna, 1965, vol. 21, p. 143–50. .
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Powder (A06JD)
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Unspecified (F598A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
6.84
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Internal remarks:
saponins in seeds
Composition #4: Brandl, J. Ueber Sapotoxin und Sapogenin von Agrostemma Githago. archiv für experimentelle pathologie und pharmakologie, 1906, vol. 54, no. 4-5, p. 245–284. DOI: 10.1007/BF01849038.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Unspecified (F598A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
3.26
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Internal remarks:
saponins in seeds
Composition #5: Hebestreit, P., Melzig, MF. Cytotoxic activity of the seeds from Agrostemma githago var. githago. planta medica, 2003, vol. 69, no. 10, p. 921–925. .
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
NaCl sodium phosphate buffer (5mM) at pH 7.4
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Substance:
Saponins (RF-00004333-PAR)
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Additional substance description:
agrostemmasaponin 1, agrostemmasaponin 2, helianthussaponin
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
TLC, HPLC
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
agrostemmasaponin 1, agrostemmasaponin 2, helianthussaponin in seeds
Composition #6: Melzig, MF., Hebestreit, P., Gaidi, G., Lacaille-Dubois, MA. Structure-activity-relationship of saponins to enhance toxic effects of agrostin . planta medica, 2005, vol. 71, no. 11, p. 1088–1090. DOI: 10.1055/s-2005-873112.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Substance:
Lectins (RF-00000439-ORG)
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Additional substance description:
agrostin
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
agrostin
Endpoint study
#1: Kotz, J. Morphology and pathogenesis of corn cockle (Agrostemma githago) poisoning in poultry. II. Own investigations.. medycyna weterynaryjna, 1965, vol. 21, p. 143–50. .
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Study relevance:
Animal (target species) health
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Substance:
Saponins (RF-00004333-PAR)
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Powder (A06JD)
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Type of toxicological test:
other (CHD008TT)
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Tested organism:
Gallus gallus (chicken) (as animal) (A057Z)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
batch (food/feed) (G204A)
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Control groups used:
no data
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Grams per kilogram body weight (G226A)
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Effect concentration:
2.5-8.0
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Critical effect:
HEMOPOIETIC (TOX10A)
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Target tissue:
Cardiovascular / Haematological (TT001A)
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Effect description:
hematological results: hemoglobin levels, blood cell counts, body wts.
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Effect or parameter linked to the endpoint:
haematology (CHD023BE)
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Internal remarks:
Saponins: acute toxicity in chickens
Endpoint study
#2: Kotz, J. Morphology and pathogenesis of corn cockle (Agrostemma githago) poisoning in poultry. II. Own investigations.. medycyna weterynaryjna, 1965, vol. 21, p. 143–50. .
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Study relevance:
Animal (target species) health
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Substance:
Saponins (RF-00004333-PAR)
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Powder (A06JD)
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Type of toxicological test:
chronic/long term toxicity (CHD004TT)
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Tested organism:
Gallus gallus (chicken) (as animal) (A057Z)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Day (G134A)
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Control groups used:
no data
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Grams per kilogram body weight (G226A)
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Effect concentration:
0.5-12
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Critical effect:
HEMOPOIETIC (TOX10A)
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Target tissue:
Cardiovascular / Haematological (TT001A)
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Effect description:
hematological results: hemoglobin levels, blood cell counts, body wts.
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Effect or parameter linked to the endpoint:
haematology (CHD023BE)
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Internal remarks:
Saponins: chronic toxicity in chickens
