EFSA Compendium of Botanicals

Draft - work in progress

Agastache rugosa (Fisch. & C.A.Mey.) Kuntze

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 1308
Number of processed references:: 4

Compositions

#1: estragol in aerial parts #2: Menthone #3: Myrcene #4: methyleugenol in fruit #5: menthone in fruit #6: pulegone in flowering top #7: menthone in flowering top #8: isomenthone in flowering top #9: isomenthone in fruit #10: estragol in fruit #11: methyleugenol in flowering top #12: pulegone in fruit #13: estragol in flowering top #14: Estragole (methyl chavicol) #15: Pulegone #16: methyleugenol

Endpoint Studies

Genotoxicity

Composition #1: Ahn, Bin., Yang, Cha Bum. Volatile flavor components of bangah (Agastache rugosa O. Kuntze) herb.. han'guk sikp'um kwahakhoechi, 1991, vol. 23, no. 5, p. 582–6. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

Estragole (RF-00003806-PAR)
Additional substance description:

in young vs. ripened plants
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

87.4-92.8
Internal remarks:

estragol in aerial parts

Composition #2: Kim, Kwang-Ho., Cho, Yong-Hyun., Lee, Jeong-Heui. Variability of the Volatile Composition of Agastache rugosa in South Korea . korean journal of breeding science, 2002, vol. 34, no. 2, p. 100–104. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

The leaves were freeze-dried
Substance:

menthone (RF-00011280-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.01-78.03
Internal remarks:

Menthone

Composition #3: Kim, Kwang-Ho., Cho, Yong-Hyun., Lee, Jeong-Heui. Variability of the Volatile Composition of Agastache rugosa in South Korea . korean journal of breeding science, 2002, vol. 34, no. 2, p. 100–104. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

The leaves were freeze-dried
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.02-6.99
Internal remarks:

Myrcene

Composition #4: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.4-5.4
Internal remarks:

methyleugenol in fruit

Composition #5: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

menthone (RF-00011280-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.6-6.7
Internal remarks:

menthone in fruit

Composition #6: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

14.5-19.4
Internal remarks:

pulegone in flowering top

Composition #7: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

menthone (RF-00011280-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.6-8.4
Internal remarks:

menthone in flowering top

Composition #8: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

d,l-Isomenthone (RF-00010214-PAR)
Additional substance description:

isomenthone
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

21.1-46.3
Internal remarks:

isomenthone in flowering top

Composition #9: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

d,l-Isomenthone (RF-00010214-PAR)
Additional substance description:

isomenthone
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

31.7-36.8
Internal remarks:

isomenthone in fruit

Composition #10: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Estragole (RF-00003806-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

22.9-24.5
Internal remarks:

estragol in fruit

Composition #11: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.7-7.9
Internal remarks:

methyleugenol in flowering top

Composition #12: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.7-11.0
Internal remarks:

pulegone in fruit

Composition #13: Skakovskii, E. D., Kiselev, W. P., Tychinskaya, L. Yu., Schutova, A. G., Gonsharova, L. W., Spiridowish, E. W., Bovdey, N. A., Kiselev, P. A., Gaidukevich, O. A. Characterization of the essential oil of Agastache rugosa by NMR spectroscopy . journal of applied spectroscopy, 2010, vol. 77, no. 3, p. 329–334. DOI: 10.1007/s10812-010-9335-3. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Estragole (RF-00003806-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

NMR spectroscopy
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6-26.3
Internal remarks:

estragol in flowering top

Composition #14: CHARLES, DJ., SIMON, JE., WIDRLECHNER, MP. CHARACTERIZATION OF ESSENTIAL OIL OF AGASTACHE SPECIES. journal of agricultural and food chemistry, 1991, vol. 39, no. 11, p. 1946–1949. DOI: 10.1021/jf00011a011. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Estragole (RF-00003806-PAR)
Additional substance description:

methylchavicol
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

55.9-93.7
Internal remarks:

Estragole (methyl chavicol)

Composition #15: CHARLES, DJ., SIMON, JE., WIDRLECHNER, MP. CHARACTERIZATION OF ESSENTIAL OIL OF AGASTACHE SPECIES. journal of agricultural and food chemistry, 1991, vol. 39, no. 11, p. 1946–1949. DOI: 10.1021/jf00011a011. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.06-8.72
Internal remarks:

Pulegone

Composition #16: CHARLES, DJ., SIMON, JE., WIDRLECHNER, MP. CHARACTERIZATION OF ESSENTIAL OIL OF AGASTACHE SPECIES. journal of agricultural and food chemistry, 1991, vol. 39, no. 11, p. 1946–1949. DOI: 10.1021/jf00011a011. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.09-9.08
Internal remarks:

methyleugenol