EFSA Compendium of Botanicals

Draft - work in progress

Aegopodium podagraria L.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 364
Number of processed references:: 8

Compositions

#1: Apterin is possibly present in small amounts in Aegopodium podagraria L #2: daidzin, leaves, HPLC-ELISA #3: isoformononetin, leaves, HPLC-ELISA #4: prunetin, leaves, HPLC-ELISA #5: formononetin, leaves, HPLC-ELISA #6: methylisoeugenol, leaves (2 ng/gle) #7: falcarinol and falcarindiol in leaves #8: bergapten, leaves (9 ng/gle) #9: methoxsalen, leaves (12ng/gle) #10: furanocoumarins in leaves #11: falcarindiol in flowers #12: falcarindiol in live plant #13: myrcene,leaves, gc-ms #14: lectins

Endpoint Studies

#1: oestrogenic effect in mice

Genotoxicity

Composition #1: Fischer, Frederik C., Svendsen, A. Baerheim. Apterin, a common furanocoumarin glycoside in the umbelliferae.. phytochemistry (elsevier), 1976, vol. 15, no. 6, p. 1079–80. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

isopropanol extract
Substance:

apterin (RF-00004152-PAR)
Additional substance description:

furanocoumarin
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Apterin is possibly present in small amounts in Aegopodium podagraria L

Composition #2: Abdulmanea, Khaled., Prokudina, Elena A., Lankova, Petra., Vanickova, Lucie., Koblovska, Radka., Zeleny, Vaclav., Lapcik, Oldrich. Immunochemical and HPLC identification of isoflavonoids in the Apiaceae family.. biochemical systematics and ecology, 2012, vol. 45, p. 237–243. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

daidzin (RF-00003763-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

HPLC-ELISA
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

daidzin, leaves, HPLC-ELISA

Composition #3: Abdulmanea, Khaled., Prokudina, Elena A., Lankova, Petra., Vanickova, Lucie., Koblovska, Radka., Zeleny, Vaclav., Lapcik, Oldrich. Immunochemical and HPLC identification of isoflavonoids in the Apiaceae family.. biochemical systematics and ecology, 2012, vol. 45, p. 237–243. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Isoformononetin (RF-00011018-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

HPLC-ELISA
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoformononetin, leaves, HPLC-ELISA

Composition #4: Abdulmanea, Khaled., Prokudina, Elena A., Lankova, Petra., Vanickova, Lucie., Koblovska, Radka., Zeleny, Vaclav., Lapcik, Oldrich. Immunochemical and HPLC identification of isoflavonoids in the Apiaceae family.. biochemical systematics and ecology, 2012, vol. 45, p. 237–243. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Prunetin (RF-00011016-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

HPLC-ELISA
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

prunetin, leaves, HPLC-ELISA

Composition #5: Abdulmanea, Khaled., Prokudina, Elena A., Lankova, Petra., Vanickova, Lucie., Koblovska, Radka., Zeleny, Vaclav., Lapcik, Oldrich. Immunochemical and HPLC identification of isoflavonoids in the Apiaceae family.. biochemical systematics and ecology, 2012, vol. 45, p. 237–243. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

formononetin (RF-00000291-NTR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

HPLC-ELISA
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

formononetin, leaves, HPLC-ELISA

Composition #6: Degen, T., Buser, HR., Stadler, E. Patterns of oviposition stimulants for carrot fly in leaves of various host plants . journal of chemical ecology, 1999, vol. 25, no. 1, p. 67–87. DOI: 10.1023/A:1020837116467. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and diethyl ether
Substance:

methylisoeugenol (RF-00003493-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

methylisoeugenol, leaves (2 ng/gle)

Composition #7: Degen, T., Buser, HR., Stadler, E. Patterns of oviposition stimulants for carrot fly in leaves of various host plants . journal of chemical ecology, 1999, vol. 25, no. 1, p. 67–87. DOI: 10.1023/A:1020837116467. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and diethyl ether
Substance:

falcarindiol (RF-00003811-PAR)
Additional substance description:

falcarinol and falcarindiol
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

falcarinol and falcarindiol in leaves

Composition #8: Degen, T., Buser, HR., Stadler, E. Patterns of oviposition stimulants for carrot fly in leaves of various host plants . journal of chemical ecology, 1999, vol. 25, no. 1, p. 67–87. DOI: 10.1023/A:1020837116467. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and diethyl ether
Substance:

Bergapten (RF-00003837-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

bergapten, leaves (9 ng/gle)

Composition #9: Degen, T., Buser, HR., Stadler, E. Patterns of oviposition stimulants for carrot fly in leaves of various host plants . journal of chemical ecology, 1999, vol. 25, no. 1, p. 67–87. DOI: 10.1023/A:1020837116467. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and diethyl ether
Substance:

Methoxsalen Methoxsalen (RF-00003863-PAR)
Additional substance description:

xanthotoxin
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

methoxsalen, leaves (12ng/gle)

Composition #10: Ojala, T., Vuorela, P., Kiviranta, J., Vuorela, H., Hiltunen, R. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins . planta medica, 1999, vol. 65, no. 8, p. 715–718. DOI: 10.1055/s-1999-14049. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Furanocoumarins (RF-00004381-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Microgram/millilitre (G052A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.1-12
Internal remarks:

furanocoumarins in leaves

Composition #11: Prior, Rikke M., Lundgaard, Nanna H., Light, Mamie E., Stafford, Gary I., van Staden, Johannes., Jaeger, Anna K. The polyacetylene falcarindiol with COX-1 activity isolated from Aegopodium podagraria L. . journal of ethnopharmacology, 2007, vol. 113, no. 1, p. 176–178. DOI: 10.1016/j.jep.2007.05.005. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

falcarindiol (RF-00003811-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

NMR
Result unit:

Milligram/gram (G060A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

88
Internal remarks:

falcarindiol in flowers

Composition #12: Prior, Rikke M., Lundgaard, Nanna H., Light, Mamie E., Stafford, Gary I., van Staden, Johannes., Jaeger, Anna K. The polyacetylene falcarindiol with COX-1 activity isolated from Aegopodium podagraria L. . journal of ethnopharmacology, 2007, vol. 113, no. 1, p. 176–178. DOI: 10.1016/j.jep.2007.05.005. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water, methanol, acetone, dichloromethane, ethyl acetate or hexane
Substance:

falcarindiol (RF-00003811-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

NMR
Result unit:

Milligram/gram (G060A)
Result expression:

Whole weight (B001A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5-85
Internal remarks:

falcarindiol in live plant

Composition #13: BORGKARLSON, AK., VALTEROVA, I., NILSSON, LA. VOLATILE COMPOUNDS FROM FLOWERS OF 6 SPECIES IN THE FAMILY APIACEAE - BOUQUETS FOR DIFFERENT POLLINATORS . phytochemistry, 1994, vol. 35, no. 1, p. 111–119. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.6
Internal remarks:

myrcene,leaves, gc-ms

Composition #14: Battelli, MG., Barbieri, L., Bolognesi, A., Buonamici, L., Valbonesi, P., Polito, L., VanDamme, EJM., Peumans, WJ., Stirpe, F. Ribosome-inactivating lectins with polynucleotide: Adenosine glycosidase activity . febs letters, 1997, vol. 408, no. 3, p. 355–359. DOI: 10.1016/S0014-5793(97)00463-8. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

Lectins (RF-00000439-ORG)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lectins

Endpoint study #1: Bergeron, Jean Marie., Goulet, Marie. Study on the phytoestrogenic and phytotoxic effects of open-land plants on the laboratory mouse.. canadian journal of zoology, 1980, vol. 58, no. 9, p. 1575–81. .

Study relevance:

Human health
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

food containing dried plant on mice in relation with an oestrogenic effect : loss of development (24.8%) and enhancing of the weight of uterus (45.4%)
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

oestrogenic effect in mice