EFSA Compendium of Botanicals

Draft - work in progress

Aconitum anthora L.

Family:: Ranunculaceae
Approval state:: Approved
Number of articles retrieved:: 29
Number of processed references:: 3

Compositions

#1: anthorine and pseudo-anthorine #2: Diterpene alkaloids in whole plant #3: Diterpene alkaloids (condelphine, nudicaulamine, isotalatizidine) in roots

Endpoint Studies

Genotoxicity

Composition #1: Goris, A., Metin, M. Presence of two alkaloids in Aconitum anthora L.. zzz, 1925, vol. 180, p. 968–9. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

alcohol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

anthorine and pseudo-anthorine
Analytical method code:

Shaking in a Vessel Technique (F182A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2
Internal remarks:

anthorine and pseudo-anthorine

Composition #2: Forgo, Peter., Borcsa, Botond., Csupor, Dezso., Fodor, Laszlo., Robert Berkecz., Molnar, Attila, V., Hohmann, Judit. Diterpene Alkaloids from Aconitum anthora and Assessment of the hERG-Inhibiting Ability of Aconitum Alkaloids . planta medica, 2011, vol. 77, no. 4, p. 368–373. DOI: 10.1055/s-0030-1250362. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

Isotalatizidine, Hetisinone, Aconosine, Dolaconine, Acotoxicine, Acovulparine, Takaosamine, Delectinine, Delcosine, Gigactonine, Lycoctonine, Swatinine, Neolinine, Neoline, Acotoxinine, Ajacine, Septentriodine, Aconitine, Pyroaconitine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene alkaloids in whole plant

Composition #3: Pirildar, S., Gurer, C. Unsal., Kocyigit, M., Zapp, J., Kiemer, A. K., Mericli, A. H. Alkaloids from the roots of Aconitum anthora and aerial parts of Delphinium kurdicum . chemistry of natural compounds, 2013, vol. 48, no. 6, p. 1115–1116. DOI: 10.1007/s10600-013-0486-3. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether–CHCl3–MeOH mixtures
Substance:

Diterpene alkaloids (RF-00004377-PAR)
Additional substance description:

Condelphine, nudicaulamine, isotalatizidine
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpene alkaloids (condelphine, nudicaulamine, isotalatizidine) in roots