EFSA Compendium of Botanicals

Draft - work in progress

Acokanthera schimperi (A.DC.) Schweinf. // Acokanthera ouabaio Cathelineau ex Lewin // Acokanthera schimperi (A. DC.) Benth. & Hook. f.

Family:: Apocynaceae
Approval state:: Approved
Number of articles retrieved:: 40
Number of processed references:: 2

Compositions

#1: Ouabain in leaves #2: Ouabain in wood #3: ouabain #4: cardenolides (acovenoside A, acolongifloroside K, penta-O-acetylacolongifloroside K, hexa-O-acetylacolongifloroside K)

Endpoint Studies

Genotoxicity

Composition #1: Berlingozzi, S., Migliacci, D. The ouabain content of Acokanthera schimperi of Erythrea.. bollettino chimico farmaceutico, 1928, vol. 67, p. 33–5. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

.unspecified
Substance:

ouabain (RF-00003966-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.1
Internal remarks:

Ouabain in leaves

Composition #2: Berlingozzi, S., Migliacci, D. The ouabain content of Acokanthera schimperi of Erythrea.. bollettino chimico farmaceutico, 1928, vol. 67, p. 33–5. .

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

.unspecified
Substance:

ouabain (RF-00003966-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.3
Internal remarks:

Ouabain in wood

Composition #3: CASSELS, BK. ANALYSIS OF A MAASAI ARROW POISON. journal of ethnopharmacology, 1985, vol. 14, no. 2-3, p. 273–281. DOI: 10.1016/0378-8741(85)90094-7. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water, CH2Cl2
Substance:

ouabain (RF-00003966-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

ouabain

Composition #4: CASSELS, BK. ANALYSIS OF A MAASAI ARROW POISON. journal of ethnopharmacology, 1985, vol. 14, no. 2-3, p. 273–281. DOI: 10.1016/0378-8741(85)90094-7. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water, CH2Cl2
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

acovenoside A, acolongifloroside K, penta-O-acetylacolongifloroside K, hexa-O-acetylacolongifloroside K
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cardenolides (acovenoside A, acolongifloroside K, penta-O-acetylacolongifloroside K, hexa-O-acetylacolongifloroside K)