EFSA Compendium of Botanicals

Draft - work in progress

Achillea ptarmica L.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 98
Number of processed references:: 5

Compositions

#1: Trans-Pinocarveyl hydroperoxide #2: Dehydrofalcarinone #3: Trideca-triin-(7.9.1)-trien-(1.3.5) #4: ponticaepoxyde in the roots #5: Dehydromatricaria ester in the roots #6: Asarinin (sesamin) in whole live plant #7: 1,8-cineole in aerial parts #8: Camphor in aerial parts #9: alpha-thujone in flowers

Endpoint Studies

Genotoxicity

Composition #1: Ruecker, G., Manns, D., Breuer, J. Trans-Pinocarveyl hydroperoxide from Achillea ptarmica. planta medica, 1994, vol. 60, no. 2, p. 194–194. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether extraction
Substance:

guaianolides (RF-00010821-PAR)
Additional substance description:

Trans-Pinocarveyl hydroperoxide
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Trans-Pinocarveyl hydroperoxide

Composition #2: Bohlmann, Ferdinand., Arndt, Christian., Bornowski, Hans., Jastrow, Horst., Kleine, Kaethe Marie. Polyacetylenic compounds. XXXVIII. New polyynes from the tribe Anthemideae.. zzz, 1962, vol. 95, p. 1320–7. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether-diethyl ether (1:1 v/v)
Substance:

Polyynes Polyynes (RF-00004322-PAR)
Additional substance description:

Dehydrofalcarinone
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dehydrofalcarinone

Composition #3: Bohlmann, Ferdinand., Arndt, Christian., Bornowski, Hans., Jastrow, Horst., Kleine, Kaethe Marie. Polyacetylenic compounds. XXXVIII. New polyynes from the tribe Anthemideae.. zzz, 1962, vol. 95, p. 1320–7. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether-diethyl ether (1:1 v/v)
Substance:

Polyynes Polyynes (RF-00004322-PAR)
Additional substance description:

Trideca-triin-(7.9.1l)-trien-(1.3.5)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Trideca-triin-(7.9.1)-trien-(1.3.5)

Composition #4: Bohlmann, Ferdinand., Jastrow, Horst. Polyacetylene compounds. XL. The polyynes from the genus Achillea.. chemische berichte, 1962, vol. 95, p. 1742–7. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extd. twice with 1:1 petr. ether-Et2O
Substance:

polyacetylene derivatives polyacetylene derivatives (RF-00004332-PAR)
Additional substance description:

ponticaepoxyde
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

ponticaepoxyde in the roots

Composition #5: Bohlmann, Ferdinand., Jastrow, Horst. Polyacetylene compounds. XL. The polyynes from the genus Achillea.. chemische berichte, 1962, vol. 95, p. 1742–7. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

extd. twice with 1:1 petr. ether-Et2O
Substance:

Polyynes Polyynes (RF-00004322-PAR)
Additional substance description:

Dehydromatricaria ester
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dehydromatricaria ester in the roots

Composition #6: Kuropka, G., Glombitza, K W. Further Polyenic and Polyynic Carboxamides and Sesamin from Achillea ptarmica. . planta medica, 1987, vol. 53, no. 5, p. 440–2. DOI: 10.1055/s-2006-962768. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane
Substance:

asarinin (RF-00004158-PAR)
Additional substance description:

synonym: sesamin
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Asarinin (sesamin) in whole live plant

Composition #7: KUROPKA, G., NEUGEBAUER, M., GLOMBITZA, KW. ESSENTIAL OILS OF ACHILLEA-PTARMICA. planta medica, 1991, vol. 57, no. 5, p. 492–494. DOI: 10.1055/s-2006-960180. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam-distilled
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent/sample (G087A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.25-6.63
Internal remarks:

1,8-cineole in aerial parts

Composition #8: KUROPKA, G., NEUGEBAUER, M., GLOMBITZA, KW. ESSENTIAL OILS OF ACHILLEA-PTARMICA. planta medica, 1991, vol. 57, no. 5, p. 492–494. DOI: 10.1055/s-2006-960180. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam-distilled
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent/sample (G087A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.62-2.88
Internal remarks:

Camphor in aerial parts

Composition #9: KUROPKA, G., NEUGEBAUER, M., GLOMBITZA, KW. ESSENTIAL OILS OF ACHILLEA-PTARMICA. planta medica, 1991, vol. 57, no. 5, p. 492–494. DOI: 10.1055/s-2006-960180. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Steam-distilled
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent/sample (G087A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.10-2.14
Internal remarks:

alpha-thujone in flowers