Draft - work in progress
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- Acacia nilotica (L.) Delile // Acacia arabica (Lam.) Willd.
Acacia nilotica (L.) Delile // Acacia arabica (Lam.) Willd.
- Family:
- Fabaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 2581
- Number of processed references:
- 8
Composition #1: Ehsen, Saman., Qasim, Muhammad., Abideen, Zainul., Rizvi, R. Fatima., Gul, Bilquees., Ansari, Raziuddin., Khan, M. Ajmal. Secondary metabolites as anti-nutritional factors in locally used halophytic forage/fodder.. pakistan journal of botany, 2016, vol. 48, no. 2, p. 629–636. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Methanol
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.531
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Internal remarks:
saponins in leaves (0.531%)
Composition #2: Ehsen, Saman., Qasim, Muhammad., Abideen, Zainul., Rizvi, R. Fatima., Gul, Bilquees., Ansari, Raziuddin., Khan, M. Ajmal. Secondary metabolites as anti-nutritional factors in locally used halophytic forage/fodder.. pakistan journal of botany, 2016, vol. 48, no. 2, p. 629–636. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hot water
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.663
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Internal remarks:
tannins in leaves (1.663%)
Composition #3: Ehsen, Saman., Qasim, Muhammad., Abideen, Zainul., Rizvi, R. Fatima., Gul, Bilquees., Ansari, Raziuddin., Khan, M. Ajmal. Secondary metabolites as anti-nutritional factors in locally used halophytic forage/fodder.. pakistan journal of botany, 2016, vol. 48, no. 2, p. 629–636. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Substance:
Oxalates (RF-00004308-PAR)
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Result unit:
Percent (G138A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.481
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Internal remarks:
Oxalates in leaves (0.481%)
Composition #4: Auwal, Mohammed Shaibu., Saka, Sanni., Mairiga, Ismail Alhaji., Sanda, Kyari Abba., Shuaibu, Abdullahi., Ibrahim, Amina. Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica (Thorn mimosa). . veterinary research forum : an international quarterly journal, 2014, vol. 5, no. 2, p. 95–100. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
aqueous, ethyl acetate and N-butanol (plant pods)
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
saponins in plant pods
Composition #5: Auwal, Mohammed Shaibu., Saka, Sanni., Mairiga, Ismail Alhaji., Sanda, Kyari Abba., Shuaibu, Abdullahi., Ibrahim, Amina. Preliminary phytochemical and elemental analysis of aqueous and fractionated pod extracts of Acacia nilotica (Thorn mimosa). . veterinary research forum : an international quarterly journal, 2014, vol. 5, no. 2, p. 95–100. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
aqueous, ethyl acetate and N-butanol (plant pods)
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
tannins in plant pods
Composition #6: Rubanza, CDK., Shem, M., Otsyina, R., Nishino, N., Ichinohe, T., Fujihara, T. Content of phenolics and tannins in leaves and pods of some Acacia and Dichrostachys species and effects on in vitro digestibility . journal of animal and feed sciences, 2003, vol. 12, no. 3, p. 645–663. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
acetone−water (pod)
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Milligram/gram (G060A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
236
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Internal remarks:
tannins in leaves (236 mg/g)
Composition #7: Rubanza, CDK., Shem, M., Otsyina, R., Nishino, N., Ichinohe, T., Fujihara, T. Content of phenolics and tannins in leaves and pods of some Acacia and Dichrostachys species and effects on in vitro digestibility . journal of animal and feed sciences, 2003, vol. 12, no. 3, p. 645–663. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
acetone−water (pod)
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Substance:
Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Milligram/gram (G060A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
10
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Internal remarks:
Condensed tannins in pods (10 mg/g)
Composition #8: Rubanza, CDK., Shem, M., Otsyina, R., Nishino, N., Ichinohe, T., Fujihara, T. Content of phenolics and tannins in leaves and pods of some Acacia and Dichrostachys species and effects on in vitro digestibility . journal of animal and feed sciences, 2003, vol. 12, no. 3, p. 645–663. .
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-
Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
acetone−water (pod)
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Substance:
Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Milligram/gram (G060A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
55
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Internal remarks:
Condensed tannins in leaves (55 mg/g)
Composition #9: Rubanza, CDK., Shem, M., Otsyina, R., Nishino, N., Ichinohe, T., Fujihara, T. Content of phenolics and tannins in leaves and pods of some Acacia and Dichrostachys species and effects on in vitro digestibility . journal of animal and feed sciences, 2003, vol. 12, no. 3, p. 645–663. .
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-
Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
acetone−water (pod)
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Milligram/gram (G060A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
163
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Internal remarks:
tannins in pods (163 mg/g)
Composition #10: Kaur, K., Michael, H., Arora, S., Harkonen, P., Kumar, S. In vitro bioactivity-guided fractionation and characterization of polyphenolic inhibitory fractions from Acacia nilotica (L.) Willd. ex Del. . journal of ethnopharmacology, 2005, vol. 99, no. 3, p. 353–360. DOI: 10.1016/j.jep.2005.01.040.
[
DOI link]
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Plant part:
Bark (as part-nature) (A066X)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
acetone−water
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Substance:
gallic acid (RF-00003821-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
TLC
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Gallic acid in bark
Composition #11: Osuga, Isaac M., Maindi, Catherine N., Abdulrazak, Shaukat A., Nishino, Naoki., Ichinohe, Toshiyoshi., Fujihara, Tsutomu. Potential nutritive value and tannin bioassay of selected Acacia species from Kenya . journal of the science of food and agriculture, 2007, vol. 87, no. 8, p. 1533–1538. DOI: 10.1002/jsfa.2883.
[
DOI link]
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
acetone−water
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Substance:
Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Gram/kilogram (G015A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.4
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Internal remarks:
Condensed tannins in forage
Composition #12: Osuga, Isaac M., Maindi, Catherine N., Abdulrazak, Shaukat A., Nishino, Naoki., Ichinohe, Toshiyoshi., Fujihara, Tsutomu. Potential nutritive value and tannin bioassay of selected Acacia species from Kenya . journal of the science of food and agriculture, 2007, vol. 87, no. 8, p. 1533–1538. DOI: 10.1002/jsfa.2883.
[
DOI link]
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
acetone−water
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Gram/kilogram (G015A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
364.8
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Internal remarks:
tannins in forage
Endpoint study
#1: Hussain, Fahad., Poddar, Saikat Kumar., Ganguly, Amlan., Abdur Rahman, S. M. Investigation of CNS depressant, anti-diarrheal and cytotoxic activities of crude methanolic extracts of Acacia nilotica and Justicia adhatoda root.. indo american journal of pharmaceutical research, 2016, vol. 6, no. 1, p. 3954–3961. .
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
methanol
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Milligram/100 gram (G057A)
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Effect concentration:
20-40
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
neurologic: Central Nervous System (TT035A)
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Effect description:
CNS depressant activity in dose dependent manner
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
Root methanolic extracts , administered at doses of 200 and 400 mh/Kg b.w., to swiss albino mice induced CNS depression.
Endpoint study
#2: Alli, Lukman Adewale., Adesokan, Abdulfatai Ayoade., Salawu, Oluwakanyinsola Adeola., Akanji, Musbau Adewunmi. Toxicological studies of aqueous extract of Acacia nilotica root.. interdisciplinary toxicology, 2015, vol. 8, no. 1, p. 48–54. DOI: 10.1515/intox-2015-0005.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
aqueous extract
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Rat (as animal) (A0CNV)
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Route of exposure:
ORAL: GAVAGE (OECD2231PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
48
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Control groups used:
yes, concurrent no treatment
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Endpoint measured:
No observed adverse effect concentration (CHD017EP)
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Concentration unit:
Milligram/kilogram (G061A)
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Effect concentration:
250
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Critical effect:
HEPATOTOXICITY (TOX02A)
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Target tissue:
digestive: Liver (TT023A)
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Effect description:
A significant reduction in the activity of lactate dehydrogenase, and increase in alanine and aspartate aminotransferase and alkaline phosphatase. Repeated administration in rats may cause hepatotoxicity
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Effect or parameter linked to the endpoint:
no adverse effect observed at single/highest dose (CHD033BE)
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Internal remarks:
Potential hepatotoxicity in rats
Genotox #1: Arora, S., Brits, E., Kaur, S., Kaur, K., Sohi, RS., Kumar, S., Verschaeve, L. Evaluation or genotoxicity of medicinal plant extracts by the comet and VITOTOX (R) tests . journal of environmental pathology toxicology and oncology, 2005, vol. 24, no. 3, p. 193–200. DOI: 10.1615/JEnvPathToxOncol.v24.i3.50.
[
DOI link]
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Study category:
Mutagenicity
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Type of toxicological test:
DNA damage and repair assay, unscheduled DNA synthesis in mammalian cells in vitro (CHD038TT)
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Tested organism:
Human (as organism) (A056J)
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Strain of test organism:
WI-38 cells - Human (CHD169ST)
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Endpoint measured:
DNA damage and/or repair
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Remarks on genotox study:
Extract of Acacia nilotica (n-ac) showed increased DNA damage (compared to the unexposed control sample) only at the highest concentration (2500 ppm)
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Internal remarks:
DNA damage in human blood cells
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Internal ID:
WOS:000230859400005