EFSA Compendium of Botanicals

Draft - work in progress

Abroma augusta (L.) L. f.

Family:: Malvaceae
Approval state:: Approved
Number of articles retrieved:: 103
Number of processed references:: 6

Compositions

#1: Alkaloids were detected in the hexane and ethanol-water(50:50) extracts of stem. #2: Anthraquinones were detected in the chloroform and ehanol-water (50:50) extracts of stem #3: Saponins were detected in the ethanol-water (50:50) extract of stem. #4: Tannins in whole plant #5: Alkaloids in whole plant #6: Alkaloid abromine hydrochloride found in roots #7: The alkaloid abromine was detected in the root part. #8: Choline has been detected in root.

Endpoint Studies

#1: In vitro enzyme Inhibition of chicken lipase of a metanolic extract of live plant. #2: Powdered roots act as an abortifcient and anti-fertility agent; petroleum-ether of root (at a dose of 50 mg/kg b.w.) showed anti-implantation as well as aborrtifacient activity in mice #3: CNS depressant activity in young albino rats #4: The petroleum ether extract of the root was found to be active both as anti-implantation agent and abortifacient agent in mice at the dose of 50 mg/Kg b.w.

Genotoxicity

Composition #1: Talukdar, Simi., Adhikari, Partha Pradip., Borah, Ananta. Ethnomedicobotanical study of indigenous knowledge on medicinal plants used for the treatment of reproductive problems in Nalbari district, Assam, India. . journal of ethnopharmacology, 2017 . DOI: 10.1016/j.jep.2017.07.024. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane and ethanol-water(50:50)
Substance:

Alkaloids (RF-00004360-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids were detected in the hexane and ethanol-water(50:50) extracts of stem.

Composition #2: Talukdar, Simi., Adhikari, Partha Pradip., Borah, Ananta. Ethnomedicobotanical study of indigenous knowledge on medicinal plants used for the treatment of reproductive problems in Nalbari district, Assam, India. . journal of ethnopharmacology, 2017 . DOI: 10.1016/j.jep.2017.07.024. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform and ethanol-water (50:50)
Substance:

anthraquinones (RF-00004343-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinones were detected in the chloroform and ehanol-water (50:50) extracts of stem

Composition #3: Talukdar, Simi., Adhikari, Partha Pradip., Borah, Ananta. Ethnomedicobotanical study of indigenous knowledge on medicinal plants used for the treatment of reproductive problems in Nalbari district, Assam, India. . journal of ethnopharmacology, 2017 . DOI: 10.1016/j.jep.2017.07.024. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol-water (50:50)
Substance:

Saponins (RF-00004333-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins were detected in the ethanol-water (50:50) extract of stem.

Composition #4: Gupta, Nidhi., Ganeshpurkar, Aditya., Jatav, Nishikant., Bansal, Divya., Dubey, Nazneen. In vitro prevention of chick pancreatic lipase activity by Abroma augusta extract . asian pacific journal of tropical biomedicine, 2012, vol. 2, no. Suppl. 2, p. S712–S715. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in whole plant

Composition #5: Gupta, Nidhi., Ganeshpurkar, Aditya., Jatav, Nishikant., Bansal, Divya., Dubey, Nazneen. In vitro prevention of chick pancreatic lipase activity by Abroma augusta extract . asian pacific journal of tropical biomedicine, 2012, vol. 2, no. Suppl. 2, p. S712–S715. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Milligram/kilogram (G061A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

18.47
Internal remarks:

Alkaloids in whole plant

Composition #6: Srivastava, G. P., Basu, N. K. Abroma augusta. I. Chemical examination.. indian journal of pharmacy, 1956, vol. 18, p. 472–5. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

90% ethanol and 1% HCl
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

abomine hydrochloride
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloid abromine hydrochloride found in roots

Composition #7: Gupta, Babita., Nayak, Satish., Solanki, Sarita. Abroma augusta Linn f: A review.. pharmacia sinica, 2011, vol. 2, no. 4, p. 253–261. .

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Abromine
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

The alkaloid abromine was detected in the root part.

Composition #8: Gupta, Babita., Nayak, Satish., Solanki, Sarita. Abroma augusta Linn f: A review.. pharmacia sinica, 2011, vol. 2, no. 4, p. 253–261. .

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

choline (RF-00000053-NTR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Choline has been detected in root.

Endpoint study #1: Gupta, Nidhi., Ganeshpurkar, Aditya., Jatav, Nishikant., Bansal, Divya., Dubey, Nazneen. In vitro prevention of chick pancreatic lipase activity by Abroma augusta extract . asian pacific journal of tropical biomedicine, 2012, vol. 2, no. Suppl. 2, p. S712–S715. .

Study relevance:

Animal (target species) health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol
Type of toxicological test:

in vitro (CHD061TT)
Tested organism:

Gallus gallus (chicken) (as animal) (A057Z)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Microgram/millilitre (G052A)
Effect concentration:

25-100
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

Inhibition of chicken lipase (25 µg/mL - 66.5%; 50 - 75.9; 75 - 82.4; 100- 88.6)
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

In vitro enzyme Inhibition of chicken lipase of a metanolic extract of live plant.

Endpoint study #2: Gupta, Babita., Nayak, Satish., Solanki, Sarita. Abroma augusta Linn f: A review.. pharmacia sinica, 2011, vol. 2, no. 4, p. 253–261. .

Study relevance:

Human health
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Petroleum-ether extract
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Mammals (as animal) (A056H)
Sex:

Female
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

50
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

anti-implantation and abortifcient
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Powdered roots act as an abortifcient and anti-fertility agent; petroleum-ether of root (at a dose of 50 mg/kg b.w.) showed anti-implantation as well as aborrtifacient activity in mice

Endpoint study #3: Zulfiker, Abu Hasanat Md., Hoque, Md Amdadul., Akter, Tanzena., Afroz, Aysha., Momin, Mohammad Abdul Motalib. Pharmacological Investigation of Selected Medicinal Plants of Bangladesh. tropical journal of pharmaceutical research, 2014, vol. 13, no. 11, p. 1925–1931. DOI: 10.4314/tjpr.v13i11.22. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol, petroleum
Type of toxicological test:

other (CHD008TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Swiss (CHD005ST)
Sex:

No data
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

120.0
Unit of exposure duration:

Minute (G074A)
Number of organisms dosed:

6
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

200
Critical effect:

NOT REPORTED (TOX17A)
Target tissue:

Neurologic (TT004A)
Effect description:

CNS depressant activity in dose dependent manner (decreased exploratory conduct as well as reduction of spontaneous motility)
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

CNS depressant activity in young albino rats

Endpoint study #4: PAKRASHI, A., BASAK, B., MOOKERJI, N. SEARCH FOR ANTIFERTILITY AGENTS FROM INDIGENOUS MEDICINAL-PLANTS. indian journal of medical research, 1975, vol. 63, no. 3, p. 378–381. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

petroleum ether
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Female
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Grams per kilogram body weight (G226A)
Effect concentration:

0.50
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

anti-implantation and abortificient
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

The petroleum ether extract of the root was found to be active both as anti-implantation agent and abortifacient agent in mice at the dose of 50 mg/Kg b.w.