EFSA Compendium of Botanicals

Endpoint study #1: Oliveira, Roseli F., Ribeiro, Paulo R., Santos, Getisemani K. M., Oliveira, Claudenice S., Silva, Pompilio R. C., Oliveira, Hiagno A., Trindade, Rita de C., Fernandez, Luzimar G. Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2013, vol. 23, no. 4, p. 674–679. DOI: 10.1590/S0102-695X2013005000052. [DOI link]

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Ethanol 70% (infusion and hydroalcoholic extract)
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male/Female
Route of exposure:

OTHER (OECD0PL)
Exposure duration:

45.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

8
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

125-1000
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

Hepatotoxicity (Hepatic steatosis, congestion of the hepatic vessels and presence of macrophages and lymphocytes infiltrates in the liver, accumulation of pigments)
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Hepatotoxicity in mice

Endpoint study #2: Oliveira, Roseli F., Ribeiro, Paulo R., Santos, Getisemani K. M., Oliveira, Claudenice S., Silva, Pompilio R. C., Oliveira, Hiagno A., Trindade, Rita de C., Fernandez, Luzimar G. Evaluation of the hepatotoxicity of Abarema cochliacarpos extracts in mice Mus musculus . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2013, vol. 23, no. 4, p. 674–679. DOI: 10.1590/S0102-695X2013005000052. [DOI link]

Abarema cochliocarpos (Gomes) Barneby & J.W.Grimes // Pithecellobium avaremotemo Mart.