EFSA
ecomole
vscht
  2. Uncaria tomentosa (Willd. ex Schult.) DC.

Uncaria tomentosa (Willd. ex Schult.) DC.

Family:
Rubiaceae
Approval state:
Approved
Number of articles retrieved:
670
Number of processed references:
5
Compositions
#1: Indole alkaloids #2: Tannins #3: Indole alkaloids (mitraphylline) #4: Indole alkaloids (mitraphylline, isopteropodine)
Endpoint Studies
#1: Abnormal embryos/embryotoxicity #2: Acute renal failure
Genotoxicity
Composition #1: Kuras, Mieczyslaw., Pilarski, Radoslaw., Nowakowska, Julita., Zobel, Alicja., Brzost, Krzysztof., Antosiewicz, Justyna., Gulewicz, Krzysztof. Effect of Alkaloid-Free and Alkaloid-Rich preparations from Uncaria tomentosa bark on mitotic activity and chromosome morphology evaluated by Allium Test. JOURNAL OF ETHNOPHARMACOLOGY, 2009, vol. 121, no. 1, p. 140–147. DOI: 10.1016/j.jep.2008.10.023. [DOI link]
Composition #2: Kuras, Mieczyslaw., Pilarski, Radoslaw., Nowakowska, Julita., Zobel, Alicja., Brzost, Krzysztof., Antosiewicz, Justyna., Gulewicz, Krzysztof. Effect of Alkaloid-Free and Alkaloid-Rich preparations from Uncaria tomentosa bark on mitotic activity and chromosome morphology evaluated by Allium Test. JOURNAL OF ETHNOPHARMACOLOGY, 2009, vol. 121, no. 1, p. 140–147. DOI: 10.1016/j.jep.2008.10.023. [DOI link]
Composition #3: Garcia Gimenez, Dolores., Garcia Prado, Elena., Saenz Rodriguez, Teresa., Fernandez Arche, Angeles., De la Puerta, Rocio. Cytotoxic Effect of the Pentacyclic Oxindole Alkaloid Mitraphylline Isolated from Uncaria tomentosa Bark on Human Ewing's Sarcoma and Breast Cancer Cell Lines . planta medica, 2010, vol. 76, no. 2, p. 133–136. DOI: 10.1055/s-0029-1186048. [DOI link]
Composition #4: Pilarski, Radoslaw., Filip, Beata., Wietrzyk, Joanna., Kuras, Mieczyslaw., Gulewicz, Krzysztof. Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition . phytomedicine, 2010, vol. 17, no. 14, p. 1133–1139. DOI: 10.1016/j.phymed.2010.04.013. [DOI link]
Endpoint study #1: Iziga, R., Gutierrez-Pajares, J., Pino, J. In vivo effect of Uncaria tomentosa (Willd.) D C. (Rubiaceae) "Cat's claw" on the 72 h.p.c. preimplantation mouse embryo development . boletin de la sociedad de biologia de concepcion, 1998, vol. 69, no. 0, p. 141–145. .
Endpoint study #2: Steenkamp, V., Stewart, M.J. Nephrotoxicity associated with exposure to plant toxins, with particular reference to Africa. therapeutic drug monitoring, 2005, vol. 27, no. 3, p. 270–277. DOI: 10.1097/01.ftd.0000162229.86303.67. [DOI link]