EFSA
ecomole
vscht
  2. Fenugreek (as plant) // Trigonella foenum-graecum L.

Fenugreek (as plant) // Trigonella foenum-graecum L.

Family:
Fabaceae (Leguminosae)
Approval state:
Approved
Number of articles retrieved:
3762
Number of processed references:
7
Compositions
#1: saponins in seeds #2: alkaloids in seeds #3: Steroidal saponins in seed
Endpoint Studies
#1: Higher two doses caused a significant (P<0.05) reduction in the sperm count compared to control. motility reduced; spermatozoa malformations #2: significant reduction in the mean total implants per pregnant female mice and mean live implants per pregnant female mice #3: Behavioural changes and mortality in rats were observed at a dose of 2000 mg/kg po. #4: Anti-fertility effects in rats were observed at a dose of 200 mg/kg po. #5: caused myopathy in ruminants #6: Reproductive index of mice was significantly reduced #7: Pup body weights of the treated foetuses (500and1000mg/kg/day) at birth were significantly reduced (31% and 27%, respectively) compared to the control group #8: 3 cases of external malformation for pups treated at the dose of 500mg/kg/day and 1000mg/kg/day #9: The absolute brain weight of prenatal treated mice showed a significant reduction (15% and 13%, respectively) compared to control group #10: Mice treated with SFSE-G (1000 mg/kg) showed 40% mortality #11: In the male mice, levels of eosinophils, MCH and MCHC were significantly (p < 0.01) decreased in SFSE-G (1000 mg/kg) treatment group. In female mice, RDW-SD count was significantly decreased in SFSE-G (500 and 1000 mg/kg) treatment group as compared to VC group on day 28
Genotoxicity
Composition #1: Dande, P., Patil, S. Evaluation of saponins from Trigonella foenum graecum seeds for its antifertility activity. asian journal of pharmaceutical and clinical research, 2012, vol. 5, no. SUPPL. 3, p. 154–157. .
Composition #2: Mowla, Asmena., Alauddin, M., Rahman, Md. Atiar., Ahmed, Kabir. ANTIHYPERGLYCEMIC EFFECT OF TRIGONELLA FOENUM-GRAECUM (FENUGREEK) SEED EXTRACT IN ALLOXAN-INDUCED DIABETIC RATS AND ITS USE IN DIABETES MELLITUS: A BRIEF QUALITATIVE PHYTOCHEMICAL AND ACUTE TOXICITY TEST ON THE EXTRACT . african journal of traditional complementary and alternative medicines, 2009, vol. 6, no. 3, p. 255–261. .
Composition #3: Kawabata, Tetsuro., Cui, Ming-Yue., Hasegawa, Tatsuya., Takano, Fumihide., Ohta, Tomihisa. Anti-Inflammatory and Anti-Melanogenic Steroidal Saponin Glycosides from Fenugreek (Trigonella foenum-graecum L.) Seeds . planta medica, 2011, vol. 77, no. 7, p. 705–710. DOI: 10.1055/s-0030-1250477. [DOI link]
Endpoint study #1: Al-Yahya, Abdulaziz A. Reproductive, cytological and biochemical toxicity of fenugreek in male Swiss albino mice. african journal of pharmacy and pharmacology, 2013, p. 2072–2080. .
Endpoint study #2: Al-Yahya, Abdulaziz A. Reproductive, cytological and biochemical toxicity of fenugreek in male Swiss albino mice. african journal of pharmacy and pharmacology, 2013, p. 2072–2080. .
Endpoint study #3: Dande, P., Patil, S. Evaluation of saponins from Trigonella foenum graecum seeds for its antifertility activity. asian journal of pharmaceutical and clinical research, 2012, vol. 5, no. SUPPL. 3, p. 154–157. .
Endpoint study #4: Dande, P., Patil, S. Evaluation of saponins from Trigonella foenum graecum seeds for its antifertility activity. asian journal of pharmaceutical and clinical research, 2012, vol. 5, no. SUPPL. 3, p. 154–157. .
Endpoint study #5: Shlosberg, A., Egyed, M N. Examples of poisonous plants in Israel of importance to animals and man.. archives of toxicology. supplement. = archiv fur toxikologie. supplement, 1983, vol. 6, p. 194–6. .
Endpoint study #6: Khalki, Loubna., M'hamed, Saadia Ba., Bennis, Mohamed., Chait, Abderrahman., Sokar, Zahra. Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice . journal of ethnopharmacology, 2010, vol. 131, no. 2, p. 321–325. DOI: 10.1016/j.jep.2010.06.033. [DOI link]
Endpoint study #7: Khalki, Loubna., M'hamed, Saadia Ba., Bennis, Mohamed., Chait, Abderrahman., Sokar, Zahra. Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice . journal of ethnopharmacology, 2010, vol. 131, no. 2, p. 321–325. DOI: 10.1016/j.jep.2010.06.033. [DOI link]
Endpoint study #8: Khalki, Loubna., M'hamed, Saadia Ba., Bennis, Mohamed., Chait, Abderrahman., Sokar, Zahra. Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice . journal of ethnopharmacology, 2010, vol. 131, no. 2, p. 321–325. DOI: 10.1016/j.jep.2010.06.033. [DOI link]
Endpoint study #9: Khalki, Loubna., M'hamed, Saadia Ba., Bennis, Mohamed., Chait, Abderrahman., Sokar, Zahra. Evaluation of the developmental toxicity of the aqueous extract from Trigonella foenum-graecum (L.) in mice . journal of ethnopharmacology, 2010, vol. 131, no. 2, p. 321–325. DOI: 10.1016/j.jep.2010.06.033. [DOI link]
Endpoint study #10: Kandhare, Amit D., Bodhankar, Subhash L., Mohan, V., Thakurdesai, Prasad A. Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice . regulatory toxicology and pharmacology, 2015, vol. 72, no. 2, p. 323–334. DOI: 10.1016/j.yrtph.2015.05.003. [DOI link]
Endpoint study #11: Kandhare, Amit D., Bodhankar, Subhash L., Mohan, V., Thakurdesai, Prasad A. Acute and repeated doses (28 days) oral toxicity study of glycosides based standardized fenugreek seed extract in laboratory mice . regulatory toxicology and pharmacology, 2015, vol. 72, no. 2, p. 323–334. DOI: 10.1016/j.yrtph.2015.05.003. [DOI link]