EFSA Compendium of Botanicals

Draft - work in progress

Common chickweed (as plant) // Stellaria media (L.) Vill.

Family:: Caryophyllaceae
Approval state:: Approved
Number of articles retrieved:: 1771
Number of processed references:: 5

Compositions

#1: Anthraquinones #2: Saponins #3: Cardiac gycosides #4: Oxalic acid #5: Formononetin #6: Scopoletin #7: Genistein #8: Genistin #9: Glycitein #10: Ononin #11: Sophoricoside

Endpoint Studies

#1: In vitro inhibition of lipase #2: In vitro inhibition of alpha-amylase

Genotoxicity

Composition #1: Huang, Yuan., Dong, Qi., Qiao, Shan-Yi. Chemical constituents from Stellaria media. Jiefangjun Yaoxue Xuebao, 2007, p. 185–187. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

anthraquinones (RF-00004343-PAR)
Additional substance description:

Emodin, physcion, questin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

Chromatographic separation, spectral analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinones

Composition #2: Shah, Naseer Ali., Khan, Muhammad Rashid., Nadhman, Akhtar. Antileishmanial, toxicity, and phytochemical evaluation of medicinal plants collected from Pakistan. . biomed research international, 2014, vol. 2014, p. 384204–384204. DOI: 10.1155/2014/384204. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #3: Shah, Naseer Ali., Khan, Muhammad Rashid., Nadhman, Akhtar. Antileishmanial, toxicity, and phytochemical evaluation of medicinal plants collected from Pakistan. . biomed research international, 2014, vol. 2014, p. 384204–384204. DOI: 10.1155/2014/384204. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac gycosides

Composition #4: Guil, JL., Rodriguez-Garcia, I., Torija, E. Nutritional and toxic factors in selected wild edible plants. PLANT FOODS FOR HUMAN NUTRITION, 1997, vol. 51, no. 2, p. 99–107. DOI: 10.1023/A:1007988815888. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

oxalic acid (RF-00000356-NTR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Milligram/100 gram (G057A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

370
Internal remarks:

Oxalic acid

Composition #5: Miksatkova, Petra., Ancheeva, Elena., Hejtmankova, Katerina., Teslov, Leonid., Lapcik, Oldrich. DETERMINATION OF FLAVONOIDS IN STELLARIA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY. ANALYTICAL LETTERS, 2014, vol. 47, no. 14, p. 2317–2331. DOI: 10.1080/00032719.2014.908382. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (70%)
Substance:

formononetin (RF-00000291-NTR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Nanogram/gram (G076A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11.19
Internal remarks:

Formononetin

Composition #6: Miksatkova, Petra., Ancheeva, Elena., Hejtmankova, Katerina., Teslov, Leonid., Lapcik, Oldrich. DETERMINATION OF FLAVONOIDS IN STELLARIA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY. ANALYTICAL LETTERS, 2014, vol. 47, no. 14, p. 2317–2331. DOI: 10.1080/00032719.2014.908382. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (70%)
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Microgram/gram (G049A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.21
Internal remarks:

Scopoletin

Composition #7: Miksatkova, Petra., Ancheeva, Elena., Hejtmankova, Katerina., Teslov, Leonid., Lapcik, Oldrich. DETERMINATION OF FLAVONOIDS IN STELLARIA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY. ANALYTICAL LETTERS, 2014, vol. 47, no. 14, p. 2317–2331. DOI: 10.1080/00032719.2014.908382. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (70%)
Substance:

genistein (RF-00000297-NTR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Nanogram/gram (G076A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

51.80
Internal remarks:

Genistein

Composition #8: Miksatkova, Petra., Ancheeva, Elena., Hejtmankova, Katerina., Teslov, Leonid., Lapcik, Oldrich. DETERMINATION OF FLAVONOIDS IN STELLARIA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY. ANALYTICAL LETTERS, 2014, vol. 47, no. 14, p. 2317–2331. DOI: 10.1080/00032719.2014.908382. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (70%)
Substance:

genistin (RF-00003829-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Nanogram/gram (G076A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

991.54
Internal remarks:

Genistin

Composition #9: Miksatkova, Petra., Ancheeva, Elena., Hejtmankova, Katerina., Teslov, Leonid., Lapcik, Oldrich. DETERMINATION OF FLAVONOIDS IN STELLARIA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY. ANALYTICAL LETTERS, 2014, vol. 47, no. 14, p. 2317–2331. DOI: 10.1080/00032719.2014.908382. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (70%)
Substance:

glycitein (RF-00000302-NTR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Nanogram/gram (G076A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.60
Internal remarks:

Glycitein

Composition #10: Miksatkova, Petra., Ancheeva, Elena., Hejtmankova, Katerina., Teslov, Leonid., Lapcik, Oldrich. DETERMINATION OF FLAVONOIDS IN STELLARIA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY. ANALYTICAL LETTERS, 2014, vol. 47, no. 14, p. 2317–2331. DOI: 10.1080/00032719.2014.908382. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (70%)
Substance:

Ononin (RF-00011023-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Nanogram/gram (G076A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

122.85
Internal remarks:

Ononin

Composition #11: Miksatkova, Petra., Ancheeva, Elena., Hejtmankova, Katerina., Teslov, Leonid., Lapcik, Oldrich. DETERMINATION OF FLAVONOIDS IN STELLARIA BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY. ANALYTICAL LETTERS, 2014, vol. 47, no. 14, p. 2317–2331. DOI: 10.1080/00032719.2014.908382. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (70%)
Substance:

Sophoricoside (RF-00011011-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Nanogram/gram (G076A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

266.36
Internal remarks:

Sophoricoside

Endpoint study #1: Rani, Neerja., Vasudeva, Neeru., Sharma, Surendra Kumar. Quality assessment and anti-obesity activity of Stellaria media (Linn.) Vill . bmc complementary and alternative medicine, 2012, vol. 12 . DOI: 10.1186/1472-6882-12-145. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional plant/substance description:

Lyophilised juice of the herb
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

3.71
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

In vitro inhibition of lipase
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

In vitro inhibition of lipase

Endpoint study #2: Rani, Neerja., Vasudeva, Neeru., Sharma, Surendra Kumar. Quality assessment and anti-obesity activity of Stellaria media (Linn.) Vill . bmc complementary and alternative medicine, 2012, vol. 12 . DOI: 10.1186/1472-6882-12-145. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional plant/substance description:

Lyophilised juice of the herb
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

4.53
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

In vitro inhibition of alpha-amylase
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

In vitro inhibition of alpha-amylase