EFSA Compendium of Botanicals

Draft - work in progress

Scrophularia nodosa L.

Family:: Scrophulariaceae
Approval state:: Approved
Number of articles retrieved:: 143
Number of processed references:: 3

Compositions

#1: Alkaloids #2: Tannins #3: Saponins #4: Cardiac glycosides #5: Rhein

Endpoint Studies

#1: Cases of diarrhoea and hematuria in animals

Genotoxicity

Composition #1: Onitsev, P. I. Pharmacological action of figwort (Scrophularia nodosa). farmakologiya i toksikologiya (moscow), 1944, p. 54–57. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol (70%)
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #2: Karimova, S. G., Smirnova, S. G., Nasyrov, Kh. M. Chemical composition and pharmacology of the Scrophulariaceae. dtsch. brau., 1966, p. 153–155. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

Unspecified
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #3: Karimova, S. G., Smirnova, S. G., Nasyrov, Kh. M. Chemical composition and pharmacology of the Scrophulariaceae. dtsch. brau., 1966, p. 153–155. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

unspecified
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #4: Faivre, C. Scrophularia nodosa. phytotherapie, 2007, p. 154–158. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

Unspecified
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides

Composition #5: Faivre, C. Scrophularia nodosa. phytotherapie, 2007, p. 154–158. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional extraction description:

Unspecified
Substance:

rhein (RF-00004027-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Rhein

Endpoint study #1: Faivre, C. Scrophularia nodosa. phytotherapie, 2007, p. 154–158. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Animals (as animal) (A04SF)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

Cases of diarrhoea and hematuria in some animals possibly due to rhein or saponins.
Effect or parameter linked to the endpoint:

not reported (CHD030BE)
Internal remarks:

Cases of diarrhoea and hematuria in animals