EFSA Compendium of Botanicals

Draft - work in progress

Schisandra sphenanthera Rehder & E.H.Wilson

Family:: Schisandraceae
Approval state:: Approved
Number of articles retrieved:: 333
Number of processed references:: 5

Compositions

#1: Schisandrin #2: Deoxyschizandrin #3: Schizandrin B #4: Deoxyschizandrin #5: Schizandrin B #6: Schizantherin A in stems #7: Schizantherin A in fruits #8: Schizantherin A in leaves #9: Lignans #10: Lignans #11: Lignans

Endpoint Studies

Genotoxicity

Composition #1: Liu, Shao-jing., Li, Yan., Zhang, Ying., Wang, Xiao-ning., Yang, Li-bin. Quantitative analysis of three lignans in Schisandra sphenanthera Rehd. Et Wils and Schisandra chinensis Baill. by RP-HPLC. yingyong huagong, 2014, p. 2107–2110. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Additional extraction description:

Unspecified
Substance:

Schisandrin (RF-00011059-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

reverse phase-HPLC
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.196
Internal remarks:

Schisandrin

Composition #2: Liu, Shao-jing., Li, Yan., Zhang, Ying., Wang, Xiao-ning., Yang, Li-bin. Quantitative analysis of three lignans in Schisandra sphenanthera Rehd. Et Wils and Schisandra chinensis Baill. by RP-HPLC. yingyong huagong, 2014, p. 2107–2110. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Additional extraction description:

Unspecified
Substance:

Schizandrin A (RF-00011062-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

reverse phase-HPLC
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

59.065
Internal remarks:

Deoxyschizandrin

Composition #3: Liu, Shao-jing., Li, Yan., Zhang, Ying., Wang, Xiao-ning., Yang, Li-bin. Quantitative analysis of three lignans in Schisandra sphenanthera Rehd. Et Wils and Schisandra chinensis Baill. by RP-HPLC. yingyong huagong, 2014, p. 2107–2110. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Additional extraction description:

Unspecified
Substance:

Schizandrin B (RF-00011061-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

reverse phase-HPLC
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.213
Internal remarks:

Schizandrin B

Composition #4: Gu, Wei., Wei, Nanyu., Wang, Zhezhi. LC analysis of lignans from Schisandra sphenanthera Rehd. et Wils.. CHROMATOGRAPHIA, 2008, vol. 67, no. 11-12, p. 979–983. DOI: 10.1365/s10337-008-0621-7. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

Schizandrin A (RF-00011062-PAR)
Analytical method code:

LC-MS (F026A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.54
Internal remarks:

Deoxyschizandrin

Composition #5: Gu, Wei., Wei, Nanyu., Wang, Zhezhi. LC analysis of lignans from Schisandra sphenanthera Rehd. et Wils.. CHROMATOGRAPHIA, 2008, vol. 67, no. 11-12, p. 979–983. DOI: 10.1365/s10337-008-0621-7. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

Schizandrin B (RF-00011061-PAR)
Additional substance description:

Gamma-Schizandrin
Analytical method code:

LC-MS (F026A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.30
Internal remarks:

Schizandrin B

Composition #6: Gu, Wei., Wei, Nanyu., Wang, Zhezhi. LC analysis of lignans from Schisandra sphenanthera Rehd. et Wils.. CHROMATOGRAPHIA, 2008, vol. 67, no. 11-12, p. 979–983. DOI: 10.1365/s10337-008-0621-7. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

Schizantherin A (RF-00011060-PAR)
Analytical method code:

LC-MS (F026A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.04-0.05
Internal remarks:

Schizantherin A in stems

Composition #7: Gu, Wei., Wei, Nanyu., Wang, Zhezhi. LC analysis of lignans from Schisandra sphenanthera Rehd. et Wils.. CHROMATOGRAPHIA, 2008, vol. 67, no. 11-12, p. 979–983. DOI: 10.1365/s10337-008-0621-7. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

Schizantherin A (RF-00011060-PAR)
Analytical method code:

LC-MS (F026A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.56
Internal remarks:

Schizantherin A in fruits

Composition #8: Gu, Wei., Wei, Nanyu., Wang, Zhezhi. LC analysis of lignans from Schisandra sphenanthera Rehd. et Wils.. CHROMATOGRAPHIA, 2008, vol. 67, no. 11-12, p. 979–983. DOI: 10.1365/s10337-008-0621-7. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3
Substance:

Schizantherin A (RF-00011060-PAR)
Analytical method code:

LC-MS (F026A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.05
Internal remarks:

Schizantherin A in leaves

Composition #9: Ren, Rong., Ci, Xin-Xin., Li, Hai-Zhou., Li, Hong-Mei., Luo, Guo-Jun., Li, Rong-Tao., Deng, Xu-Ming. New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera and Their Pro-inflammatory Cytokine Inhibitory Activities. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2010, vol. 65, no. 2, p. 211–218. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Diethyl Ether
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

Chloromethyl schisantherin B and Methylgomisin O, along with 12 other lignans
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #10: Liu, Haitao., Zhang, Jin., Li, Xingbo., Qi, Yaodong., Peng, Yong., Zhang, Bengang., Xiao, Peigen. Chemical analysis of twelve lignans in the fruit of Schisandra sphenanthera by HPLC-PAD-MS. PHYTOMEDICINE, 2012, vol. 19, no. 13, p. 1234–1241. DOI: 10.1016/j.phymed.2012.07.017. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

schisandrol A, schisandrol B, gomisin G, schisantherin A, schisantherin D, schisanhenol, (+)-anwulignan, deoxyschisandrin, schisandrin B, schisandrin C, 6-O-benzoylgomisin O, and interiotherin A
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans

Composition #11: Liang, Cheng-Qin., Hu, Jing., Shi, Yi-Ming., Shang, Shan-Zhai., Du, Xue., Zhan, Rui., Xiong, Wen-Yong., Zhang, Hong-Bin., Xiao, Wei-Lie., Sun, Han-Dong. Schisphenlignans A-E: Five New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera. CHEMICAL & PHARMACEUTICAL BULLETIN, 2013, vol. 61, no. 1, p. 96–100. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Acetone (70%)
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

schisphenlignans A, B, C, D, E
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans