Draft - work in progress
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- Schisandra berry (as plant) // Schisandra chinensis (Turcz.) Baill.
Schisandra berry (as plant) // Schisandra chinensis (Turcz.) Baill.
- Family:
- Schisandraceae
- Approval state:
- Approved
- Number of articles retrieved:
- 4042
- Number of processed references:
- 4
Composition #1: Wang Bao-lian., Hu Jin-ping., Sheng Li., Chen Hui., Li Yan. Chemical-pharmacokinetic-pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract . yaoxue xuebao, 2013, vol. 48, no. 5, p. 734–740. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
lignans (RF-00004361-PAR)
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Additional substance description:
Concentrations of the four lignans in ethanol extract were about 1.84 μg·mL−1 for schisandrin, 1.54 μg·mL−1 for schisantherin A, 2.43 μg·mL−1 for deoxyschizandrin and 1.23 μg·mL−1 for γ-schisandrin
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Analytical method code:
HPLC-UV (F021A)
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Analytical method - additional description:
HPLC-UV-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Lignans
Composition #2: Yu, Jie., Liu, Peixun., Long, Wei., Zhao, Feng. Experimental study on isolation and purification of total lignans from Schisandra chinensis and the anti-tumor activity in vitro. zhongguo yaoshi (wuhan, china), 2009, p. 1718–1720. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Soxhlet extraction method
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Substance:
lignans, total lignans, total (RF-00000322-NTR)
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Analytical method code:
Unspecified (F598A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
11.7-17.7
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Internal remarks:
Lignans
Composition #3: Tang, Shu-Hong., He, Rong-Rong., Huang, Ting., Wang, Cong-Zhi., Cao, Yun-Feng., Zhang, Yang., Kurihara, Hiroshi. The protective effect of schisandra lignans on stress-evoked hepatic metastases of P815 tumor cells in restraint mice . journal of ethnopharmacology, 2011, vol. 134, no. 1, p. 141–146. DOI: 10.1016/j.jep.2010.11.070.
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
distilled water
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Substance:
lignans, total lignans, total (RF-00000322-NTR)
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Additional substance description:
The most abundant lignans were Schizandrol A, Schizandrol B, Schisantherin A, Deoxyschizandrin, Schizandrin B and Schisandrin C
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Analytical method - additional description:
HPLC
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
lignans
Genotox #1: Hu, Yan-ping., Wang, Xin., Song, Jie., Zhang, Min., Wang, Xiu-wen., Li, Bo. Genotoxicity of Fructus Schisandrae Chinensis concoction. aibian, jibian, tubian, 2009, p. 309–312. .
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Study category:
Mutagenicity
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Type of toxicological test:
mammalian cell gene mutation assay (CHD030TT)
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Tested organism:
House mouse (as animal) (A0CNT)
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Exogenous metabolic activation applied:
with and without
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Route of exposure:
OTHER (OECD0PL)
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Control groups used:
no data
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Endpoint measured:
gene mutation
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Remarks on genotox study:
total mutation frequency showed a dose-dependent increase with metabolic activation, and was statistically significant (P 0.01) compared with neg. control with and without metabolic activation
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Internal remarks:
Fructus Schisandrae Chinensis concoction induced tk gene mutation and chromosomal damage in L5178Y cells with and without metabolic activation
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Internal ID:
CAPLUS_2010:1196
