EFSA Compendium of Botanicals

Draft - work in progress

Sugar cane (as plant) // Saccharum hybrid cultivar // Saccharum officinarum L.

Family:: Poaceae
Approval state:: Approved
Number of articles retrieved:: 2705
Number of processed references:: 2

Compositions

#1: Two unusual erythro- and threo-diastereoisomeric flavolignan 7-O-glucosides were identified together with their aglycones in leaves and bagasse.

Endpoint Studies

#1: The administration of methanol leaf extract of Saccharum officinarum ( 500 mg/kg b.w. and day) to adult female albino rats from day 1 to 21 after mating showed antifertility and contraceptive activity , attributed to anti-implantation ,blastocidal, antizygotic and abortifacient actions..

Genotoxicity

Composition #1: Colombo, R., Yariwake, JH., Queiroz, EF., Ndjoko, K., Hostettmann, K. On-line identification of sugarcane (Saccharum officinarum L.) methoxyflavones by liquid chromatography - UV detection using post-column derivatization and liquid chromatography-mass spectrometry . journal of chromatography a, 2005, vol. 1082, no. 1, p. 51–59. DOI: 10.1016/j.chroma.2005.01.083. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol/water 1:1
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

Erythro- and threo-diastereoisomeric flavolignan 7-O-glucosides were identified together with their aglycones.
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Two unusual erythro- and threo-diastereoisomeric flavolignan 7-O-glucosides were identified together with their aglycones in leaves and bagasse.

Endpoint study #1: Balamurugan, K., Pabbati, A., Madhana Gopal, K., Meganathan, M., Manavalan, R. Antifertility and contraceptive activity of methanolic extract of Saccharum officinarum Linn in rats. journal of chemical and pharmaceutical sciences, 2010, vol. 3, no. 2, p. 80–82. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol
Type of toxicological test:

reproduction toxicity (CHD009TT)
Limit test:

Yes
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Female
Exposure duration:

21.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

6
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

500
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

antifertility and contraceptive activity , attributed to anti-implantation ,blastocidal, antizygotic and abortifacient actions
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

The administration of methanol leaf extract of Saccharum officinarum ( 500 mg/kg b.w. and day) to adult female albino rats from day 1 to 21 after mating showed antifertility and contraceptive activity , attributed to anti-implantation ,blastocidal, antizygotic and abortifacient actions..