EFSA Compendium of Botanicals

Draft - work in progress

Rosa x damascena Herrm. // Rosa x damascena f. trigintipetala (Dieck) R.Keller

Family:: Rosaceae
Approval state:: Approved
Number of articles retrieved:: 993
Number of processed references:: 3

Compositions

#1: Beta-myrcene in flower essential oil #2: Eugenol in flower essential oil #3: Methyleugenol in flower essentiaol oil #4: Myrcene #5: Eugenol #6: Methyleugenol

Endpoint Studies

#1: alpha-glucosidase inhibitory activity in flowers

Genotoxicity

Composition #1: Kumar, Rakesh., Sharma, Saurabh., Sood, Swati., Agnihotri, Vijai K., Singh, Virendra., Singh, Bikram. Evaluation of several Rosa damascena varieties and Rosa bourboniana accession for essential oil content and composition in western Himalayas . journal of essential oil research, 2014, vol. 26, no. 3, p. 147–152. DOI: 10.1080/10412905.2013.829004. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Additional substance description:

beta-myrcene
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.3
Internal remarks:

Beta-myrcene in flower essential oil

Composition #2: Kumar, Rakesh., Sharma, Saurabh., Sood, Swati., Agnihotri, Vijai K., Singh, Virendra., Singh, Bikram. Evaluation of several Rosa damascena varieties and Rosa bourboniana accession for essential oil content and composition in western Himalayas . journal of essential oil research, 2014, vol. 26, no. 3, p. 147–152. DOI: 10.1080/10412905.2013.829004. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.7-1.8
Internal remarks:

Eugenol in flower essential oil

Composition #3: Kumar, Rakesh., Sharma, Saurabh., Sood, Swati., Agnihotri, Vijai K., Singh, Virendra., Singh, Bikram. Evaluation of several Rosa damascena varieties and Rosa bourboniana accession for essential oil content and composition in western Himalayas . journal of essential oil research, 2014, vol. 26, no. 3, p. 147–152. DOI: 10.1080/10412905.2013.829004. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1
Internal remarks:

Methyleugenol in flower essentiaol oil

Composition #4: Abdel-Hameed, El-Sayed S., Bazaid, Salih A., Hagag, Heba A. Chemical characterization of Rosa damascena Miller var. trigintipetala Dieck essential oil and its in vitro genotoxic and cytotoxic properties . journal of essential oil research, 2016, vol. 28, no. 2, p. 121–129. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.3
Internal remarks:

Myrcene
completed:

True

Composition #5: Abdel-Hameed, El-Sayed S., Bazaid, Salih A., Hagag, Heba A. Chemical characterization of Rosa damascena Miller var. trigintipetala Dieck essential oil and its in vitro genotoxic and cytotoxic properties . journal of essential oil research, 2016, vol. 28, no. 2, p. 121–129. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.7
Internal remarks:

Eugenol
completed:

True

Composition #6: Abdel-Hameed, El-Sayed S., Bazaid, Salih A., Hagag, Heba A. Chemical characterization of Rosa damascena Miller var. trigintipetala Dieck essential oil and its in vitro genotoxic and cytotoxic properties . journal of essential oil research, 2016, vol. 28, no. 2, p. 121–129. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.5
Internal remarks:

Methyleugenol
completed:

True

Endpoint study #1: Gholamhoseinian, A., Fallah, H., Far, F. Sharifi. Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on alpha-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats . phytomedicine, 2009, vol. 16, no. 10, p. 935–941. DOI: 10.1016/j.phymed.2009.02.020. [DOI link]

Study relevance:

Human health
Plant part:

Flower (as part-nature) (A067B)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Percent (G138A)
Effect concentration:

98
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

Methanolic extract caused 98% alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibitory activity in flowers