EFSA Compendium of Botanicals

Draft - work in progress

Dog rose (as plant) // Rosa canina L.

Family:: Rosaceae
Approval state:: Under evaluation
Number of articles retrieved:: 1272
Number of processed references:: 4

Compositions

#1: Secoisolariciresinol #2: Matairesinol #3: p-coumric acid in fruit #4: Gallotanin 1-7 in flowering top

Endpoint Studies

#1: Alpha-glucosidase inhibition by daucosterol from fruit #2: Alpha-glucosidase inhibition by D-Glucono-1,4-lactone from fruit

Genotoxicity

Composition #1: Valsta, Liisa M., Kilkkinen, Annamari., Mazur, Witold., Nurmi, Tarja., Lampi, Anna-Maija., Ovaskainen, Marja-Leena., Korhonen, Tommi., Adlercreutz, Herman., Pietinen, Pirjo. Phyto-oestrogen database of foods and average intake in Finland. British Journal of Nutrition, 2003, p. S31–S38. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

secoisolarisiresinol (RF-00000390-NTR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Microgram/kilogram (G050A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

788
Internal remarks:

Secoisolariciresinol

Composition #2: Valsta, Liisa M., Kilkkinen, Annamari., Mazur, Witold., Nurmi, Tarja., Lampi, Anna-Maija., Ovaskainen, Marja-Leena., Korhonen, Tommi., Adlercreutz, Herman., Pietinen, Pirjo. Phyto-oestrogen database of foods and average intake in Finland. British Journal of Nutrition, 2003, p. S31–S38. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

matairesinol (RF-00000331-NTR)
Analytical method code:

Gaschromatography (GC) (F037A)
Result unit:

Microgram/kilogram (G050A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

22
Internal remarks:

Matairesinol

Composition #3: Turkben, Cihat., Uylaser, Vildan., Incedayi, Bige., Celikkol, Isil. Effects of different maturity periods and processes on nutritional components of rose hip (Rosa canina L.) . journal of food agriculture & environment, 2010, vol. 8, no. 1, p. 26–30. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

p-coumric acid in fruit

Composition #4: Ieri, Francesca., Innocenti, Marzia., Possieri, Lucia., Gallori, Sandra., Mulinacci, Nadia. Phenolic composition of "bud extracts" of Ribes nigrum L., Rosa canina L. and Tilia tomentosa M.. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, vol. 115, p. 1–9. DOI: 10.1016/j.jpba.2015.06.004. [DOI link]

Language:

English (en)
Plant part:

Flowering top (as part-nature) (A166H)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Alcohol
Substance:

Gallotannins (RF-00013316-PAR)
Additional substance description:

Gallotanin 1-7
Analytical method code:

HPLC-DAD (F587A)
Analytical method - additional description:

HPLC-DAD-MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Gallotanin 1-7 in flowering top

Endpoint study #1: Asghari, Behvar., Salehi, Peyman., Farimani, Mandi Moridi., Ebrahimi, Samad Nejad. alpha-Glucosidase Inhibitors from Fruits of Rosa canina L.. records of natural products, 2015, vol. 9, no. 3, p. 276–283. .

Study relevance:

Human health
Substance:

daucosterol (RF-00003764-PAR)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

acetone
Type of toxicological test:

in vitro (CHD061TT)
Route of exposure:

OTHER (OECD0PL)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Millimole (G115A)
Effect concentration:

0.0133
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-glucosidase inhibition by daucosterol from fruit

Endpoint study #2: Asghari, Behvar., Salehi, Peyman., Farimani, Mandi Moridi., Ebrahimi, Samad Nejad. alpha-Glucosidase Inhibitors from Fruits of Rosa canina L.. records of natural products, 2015, vol. 9, no. 3, p. 276–283. .

Study relevance:

Human health
Substance:

Glucono-delta-lactone (RF-00000138-ADD)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

acetone
Type of toxicological test:

in vitro (CHD061TT)
Route of exposure:

OTHER (OECD0PL)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Millimole (G115A)
Effect concentration:

0.0065
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-glucosidase inhibition by D-Glucono-1,4-lactone from fruit