Composition #1: Chan, Po-Chuen., Fu, Peter P. Toxicity of Panax genseng - An herbal medicine and dietary supplement. journal of food and drug analysis, 2007, vol. 15, no. 4, p. 416–427. .
Language:
English (en)
Plant part:
Roots and other underground parts (as part-nature) (A067M)
Endpoint study
#1: Chan, Po-Chuen., Fu, Peter P. Toxicity of Panax genseng - An herbal medicine and dietary supplement. journal of food and drug analysis, 2007, vol. 15, no. 4, p. 416–427. .
Study relevance:
Human health
Plant part:
Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:
Solvent extraction (A0BZR)
Additional plant/substance description:
ethanol extract
Type of toxicological test:
case report (CHD060TT)
Tested organism:
Human (as organism) (A056J)
Sex:
Male/Female
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:
12.0
Unit of exposure duration:
Month (G206A)
Control groups used:
no
Endpoint measured:
Dose level (CHD014EP)
Concentration unit:
Grams per person per day (G213A)
Effect concentration:
>3
Critical effect:
NEUROTOXICITY (TOX04A)
Target tissue:
neurologic: Brain (TT034A)
Effect description:
hypertension, nervousness, sleeplessness, skin eruptions, morning diarrhea, edema; euphoric, restless, agitated, and insomniac. Ten taking high doses (15 g) felt depersonalization and confusion
Effect or parameter linked to the endpoint:
neurology (CHD027BE)
Internal remarks:
Ginseng abuse syndrome: central nerve system excitation and arousal.
