EFSA Compendium of Botanicals

Draft - work in progress

Peony (as plant) // Paeonia officinalis L.

Family:: Paeoniaceae
Approval state:: Approved
Number of articles retrieved:: 334
Number of processed references:: 4

Compositions

#1: Alkaloids #2: Tannins #3: Saponins #4: Furan-2-pentyl #5: Eugenol #6: Myrcene #7: Benzofuran, 4,7-dimethyl- #8: Benzaldehyde, 2-hydroxy-

Endpoint Studies

#1: Abortifacient effect reported in rats

Genotoxicity

Composition #1: Ahmad, Feroz., Tabassum, Nahida. Preliminary phytochemical, acute oral toxicity and antihepatotoxic study of roots of Paeonia officinalis Linn. . asian pacific journal of tropical biomedicine, 2013, vol. 3, no. 1, p. 64–68. DOI: 10.1016/S2221-1691(13)60025-8. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aqueous extract
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #2: Ahmad, Feroz., Tabassum, Nahida. Preliminary phytochemical, acute oral toxicity and antihepatotoxic study of roots of Paeonia officinalis Linn. . asian pacific journal of tropical biomedicine, 2013, vol. 3, no. 1, p. 64–68. DOI: 10.1016/S2221-1691(13)60025-8. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aqueous extract
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #3: Ahmad, Feroz., Tabassum, Nahida. Preliminary phytochemical, acute oral toxicity and antihepatotoxic study of roots of Paeonia officinalis Linn. . asian pacific journal of tropical biomedicine, 2013, vol. 3, no. 1, p. 64–68. DOI: 10.1016/S2221-1691(13)60025-8. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

aqueous extract
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins

Composition #4: Li, Xiao-ru., Liang, Yi-zeng., Guo, Fang-qiu. Analysis of volatile oil in Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra by gas chromatography-mass spectrometry and chemometric resolution. acta pharmacologica sinica, 2006, p. 491–498. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Furan-2-pentyl
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furan-2-pentyl

Composition #5: Li, Xiao-ru., Liang, Yi-zeng., Guo, Fang-qiu. Analysis of volatile oil in Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra by gas chromatography-mass spectrometry and chemometric resolution. acta pharmacologica sinica, 2006, p. 491–498. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Eugenol

Composition #6: Li, Xiao-ru., Liang, Yi-zeng., Guo, Fang-qiu. Analysis of volatile oil in Rhizoma Ligustici Chuanxiong-Radix Paeoniae Rubra by gas chromatography-mass spectrometry and chemometric resolution. acta pharmacologica sinica, 2006, p. 491–498. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Myrcene

Composition #7: Li, Xiao-ru., Lan, Zheng-gang., Liang, Yi-zeng. Analysis of volatile chemical components of Radix Paeoniae Rubra by gas chromatography-mass spectrometry and chemometric resolution. journal of central south university of technology (english edition), 2007, p. 57–61. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Benzofuran, 4,7-dimethyl-
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.41
Internal remarks:

Benzofuran, 4,7-dimethyl-

Composition #8: Li, Xiao-ru., Lan, Zheng-gang., Liang, Yi-zeng. Analysis of volatile chemical components of Radix Paeoniae Rubra by gas chromatography-mass spectrometry and chemometric resolution. journal of central south university of technology (english edition), 2007, p. 57–61. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Benzaldehyde (RF-00008323-PAR)
Additional substance description:

Benzaldehyde, 2-hydroxy-
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

17.1
Internal remarks:

Benzaldehyde, 2-hydroxy-

Endpoint study #1: Ahmad, F., Tabassum, N., Rasool, S. Medicinal uses and phytoconstituents of Paeonia officinalis. international research journal of pharmacy, 2012, p. 85–87. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Alcoholic extract (not further specifiec)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

Abortifacient effect
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Abortifacient effect reported in rats