EFSA Compendium of Botanicals

Draft - work in progress

Orthosiphon aristatus (Blume) Miq.

Family:: Lamiaceae (Labiatae)
Approval state:: Approved
Number of articles retrieved:: 161
Number of processed references:: 1

Compositions

Endpoint Studies

#1: Alpha-amylase inhibition #2: Alpha-glucosidase (maltase and sucrase) inhibition

Genotoxicity

Composition #1: Adisakwattana, Sirichai., Jiphimai, Pariwat., Prutanopajai, Pornsawan., Chanathong, Benjanut., Sapwarobol, Suwimol., Ariyapitipan, Tipayanate. Evaluation of alpha-glucosidase, alpha-amylase and protein glycation inhibitory activities of edible plants. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2010, vol. 61, no. 3, p. 295–305. DOI: 10.3109/09637480903455963. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

90 C for 2 hour in water
Substance:

Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
Analytical method code:

Phytochemical screening (F604A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

134.6
Internal remarks:

Condensed tannins

Endpoint study #1: Adisakwattana, Sirichai., Jiphimai, Pariwat., Prutanopajai, Pornsawan., Chanathong, Benjanut., Sapwarobol, Suwimol., Ariyapitipan, Tipayanate. Evaluation of alpha-glucosidase, alpha-amylase and protein glycation inhibitory activities of edible plants. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2010, vol. 61, no. 3, p. 295–305. DOI: 10.3109/09637480903455963. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hot water extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

1.04
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

alpha-amylase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-amylase inhibition

Endpoint study #2: Adisakwattana, Sirichai., Jiphimai, Pariwat., Prutanopajai, Pornsawan., Chanathong, Benjanut., Sapwarobol, Suwimol., Ariyapitipan, Tipayanate. Evaluation of alpha-glucosidase, alpha-amylase and protein glycation inhibitory activities of edible plants. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2010, vol. 61, no. 3, p. 295–305. DOI: 10.3109/09637480903455963. [DOI link]

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hot water extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

0.95-0.97
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

Alpha-glucosidase (maltase and sucrase) inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Alpha-glucosidase (maltase and sucrase) inhibition