EFSA Compendium of Botanicals

Draft - work in progress

Prickly pear (as plant) // Opuntia ficus-indica (L.) Mill.

Family:: Cactaceae
Approval state:: Approved
Number of articles retrieved:: 2345
Number of processed references:: 2

Compositions

Endpoint Studies

#1: Report of systemic toxicity in goat - apathy, anorexia, diarrhea, sensitivity to abdominal palpation, moderate dehydration, mucous membranes congestion and incoordination of the hind limbs. #2: oral LD50 of Opuntia ficus indica fixed oil in mice = 43 ± 0.8 ml/kg body wt

Genotoxicity

Endpoint study #1: Assis, Tales S., Medeiros, Rosane M. T., Riet-Correa, Franklin., Galiza, Glauco J. N., Dantas, Antonio F. M., Oliveira, Diego M. Plant poisonings diagnosed in ruminants and horses and estimation of the economical losses in Paraiba . pesquisa veterinaria brasileira, 2010, vol. 30, no. 1, p. 13–20. .

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Goat (as animal) (A057P)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

SYSTEMIC (TOX01A)
Effect description:

Report of toxicity in goats was observed in an 8-month old goat which presented apathy, anorexia, diarrhea, sensitivity to abdominal palpation, moderate dehydration, mucous membranes congestion and incoordination of the hind limbs.
Effect or parameter linked to the endpoint:

mobility (CHD011BE)
Internal remarks:

Report of systemic toxicity in goat - apathy, anorexia, diarrhea, sensitivity to abdominal palpation, moderate dehydration, mucous membranes congestion and incoordination of the hind limbs.

Endpoint study #2: Boukeloua, A., Belkhiri, A., Djerrou, Z., Bahri, L., Boulebda, N., Pacha, Y. Hamdi. ACUTE TOXICITY OF OPUNTIA FICUS INDICA AND PISTACIA LENTISCUS SEED OILS IN MICE. AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES, 2012, vol. 9, no. 4, p. 607–611. DOI: 10.4314/ajtcam.v9i4.19. [DOI link]

Study relevance:

Human health
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hexane
Type of toxicological test:

acute toxicity (CHD016TT)
Limit test:

No data
Tested organism:

House mouse (as animal) (A0CNT)
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

70
Control groups used:

yes
Endpoint measured:

Lethal dose rate in 50% of experimental organisms (CHD029EP)
Concentration unit:

millilitre per kilogram (G253A)
Effect concentration:

43
Critical effect:

NOT REPORTED (TOX17A)
Effect description:

oral LD50 of Opuntia ficus indica fixed oil in mice = 43 ± 0.8 ml/kg body wt
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

oral LD50 of Opuntia ficus indica fixed oil in mice = 43 ± 0.8 ml/kg body wt