EFSA Compendium of Botanicals

Draft - work in progress

Olive infusion leaves // Olea europaea L.

Family:: Oleaceae
Approval state:: Approved
Number of articles retrieved:: 10669
Number of processed references:: 4

Compositions

#1: Tannins reported in ethanol extract of leaves #2: Alkaloids reported in ethanol extract of leaves #3: Steroids reported in ethanol extract of leaves #4: p-coumaric acid in olive oil #5: lignans in olive oil

Endpoint Studies

Genotoxicity

#1: olive oil extracts genotoxic above 100 microgram/ml

Composition #1: Rahman, M., Khatun, A., Islam, S., Akter, A., Kawser, U. Phytopharmacological evaluation of leaves of olive-Olea Europaea. pharmacologyonline, 2015, vol. 1, p. 45–49. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins reported in ethanol extract of leaves

Composition #2: Rahman, M., Khatun, A., Islam, S., Akter, A., Kawser, U. Phytopharmacological evaluation of leaves of olive-Olea Europaea. pharmacologyonline, 2015, vol. 1, p. 45–49. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids reported in ethanol extract of leaves

Composition #3: Rahman, M., Khatun, A., Islam, S., Akter, A., Kawser, U. Phytopharmacological evaluation of leaves of olive-Olea Europaea. pharmacologyonline, 2015, vol. 1, p. 45–49. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Steroids (RF-00000309-VET)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Steroids reported in ethanol extract of leaves

Composition #4: Romani, A., Pinelli, P., Mulinacci, N., Galardi, C., Vincieri, FF., Liberatore, L., Cichelli, A. HPLC and HRGC analyses of polyphenols and secoiridoid in olive oil. chromatographia, 2001, vol. 53, no. 5-6, p. 279–284. DOI: 10.1007/BF02490424. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

olive oil extracted with EtOH/H20 70:30 v/v
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Milligram/litre (G062A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.57-2.29
Internal remarks:

p-coumaric acid in olive oil

Composition #5: Fabiani, Roberto., Sepporta, Maria V., Mazza, Teresa., Rosignoli, Patrizia., Fuccelli, Raffaela., De Bartolomeo, Angelo., Crescimanno, Marilena., Taticchi, Agnese., Esposto, Sonia., Servili, Maurizio., Morozzi, Guido. Influence of Cultivar and Concentration of Selected Phenolic Constituents on the in Vitro Chemiopreventive Potential of Olive Oil Extracts . journal of agricultural and food chemistry, 2011, vol. 59, no. 15, p. 8167–8174. DOI: 10.1021/jf201459u. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Additional extraction description:

unspecified
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

pinoresinol and acetoxypinoresinol in oil
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignans in olive oil

Genotox #1: Nousis, L., Doulias, PT., Aligiannis, N., Bazios, D., Agalias, A., Galaris, D., Mitakou, S. DNA protecting and genotoxic effects of olive oil related components in cells exposed to hydrogen peroxide . free radical research, 2005, vol. 39, no. 7, p. 787–795. DOI: 10.1080/10715760500045806. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

single cell gel/comet assay in mammalian cells for detection of DNA damage (CHD040TT)
Method type:

in vitro
Tested organism:

Human (as organism) (A056J)
Strain of test organism:

lymphocytes (CHD036ST)
Exogenous metabolic activation applied:

no data
Control groups used:

yes
Endpoint measured:

DNA damage and/or repair
Is genotoxic:

Positive
Remarks on genotox study:

above a concentration of 100 microgram/ml olive oil extracts exerted DNA damaging effects by themselves
Internal remarks:

olive oil extracts genotoxic above 100 microgram/ml
Internal ID:

WOS:000230614400014