Composition #1: Karonen, Maarit., Parker, John., Agrawal, Anurag., Salminen, Juha-Pekka. First evidence of hexameric and heptameric ellagitannins in plants detected by liquid chromatography/electrospray ionisation mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2010, vol. 24, no. 21, p. 3151–3156. DOI: 10.1002/rcm.4756.
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DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Aqueous acetone
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Substance:
Ellagitannins (hydrolysable tannins) Ellagitannins (hydrolysable tannins) (RF-00004379-PAR)
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Additional substance description:
various ellagitannin oligomers including oenothein A and B
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Analytical method code:
HPLC-DAD (F587A)
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Analytical method - additional description:
HPLC-DAS-ESI-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Ellagitannins
Endpoint study
#1: Jacobsson, Ingela., Joensson, Anna K., Gerden, Barbro., Haegg, Staffan. Spontaneously reported adverse reactions in association with complementary and alternative medicine substances in Sweden. pharmacoepidemiology and drug safety, 2009, p. 1039–1047. .
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Study relevance:
Human health
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Plant part:
Unspecified (A07XD)
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Preparation/Extraction method:
Essential oil (as part-nature) (A166Q)
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Type of toxicological test:
case report (CHD060TT)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
HEMOPOIETIC (TOX10A)
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Target tissue:
cardiovascular / haematological: Blood Coagulation (TT010A)
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Effect description:
Reported cases of venous thrombosis, impaired concentration, and other symptoms
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Effect or parameter linked to the endpoint:
not reported (CHD030BE)
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Internal remarks:
Venous thrombosis, impaired concentration, and other symptoms
Endpoint study
#2: Aitani, M., Kimura, H., Abiru, Y., Soyama, H., Murakami, H., Zhang, HL., Sugishita, T., Konishi, Y. Effect of an extract from evening-primrose seeds on postprandial blood glucose level and its active components . journal of the japanese society for food science and technology-nippon shokuhin kagaku kogaku kaishi, 2003, vol. 50, no. 4, p. 180–187. .
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
Ethanol extract
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Type of toxicological test:
in vitro (CHD061TT)
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
inhibition of alpha-glucosidase
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
inhibition of alpha-glucosidase
