EFSA Compendium of Botanicals

Draft - work in progress

Mallow (as plant) // Malva sylvestris L.

Family:: Malvaceae
Approval state:: Approved
Number of articles retrieved:: 544
Number of processed references:: 7

Compositions

#1: Total alkaloids #2: Alkaloids in seeds #3: Alkaloids in stems #4: Tannins in seeds #5: Tannins in stems #6: Saponins in stems #7: Coumarins in seeds #8: Coumarins in stems #9: Coumarin #10: 1,8-cineole in seed oil #11: Alpha-camphor in seed oil #12: Malvone A #13: Genistein #14: 5,7-dimethoxycoumarin #15: Scopoletin

Endpoint Studies

Genotoxicity

Composition #1: Shamsa, Fazel., Monsef, Hamidreza., Ghamooshi, Rouhollah., Verdian-rizi, Mohammadreza. Spectrophotometric determination of total alkaloids in some Iranian medicinal plants. thai journal of pharmaceutical sciences, 2008, p. 17–20. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

total alkaloids
Analytical method code:

Chromatographic tests (F015A)
Result unit:

Milligram/100 gram (G057A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

35.06
Internal remarks:

Total alkaloids

Composition #2: Sabri, Fatima Zohra., Belarbi, Meriem., Sabri, Samira., Alsayadi, Muneer M. S. Phytochemical screening and identification of some compounds from mallow. journal of natural product and plant resources, 2012, p. 512–516. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol or water
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in seeds

Composition #3: Sabri, Fatima Zohra., Belarbi, Meriem., Sabri, Samira., Alsayadi, Muneer M. S. Phytochemical screening and identification of some compounds from mallow. journal of natural product and plant resources, 2012, p. 512–516. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in stems

Composition #4: Sabri, Fatima Zohra., Belarbi, Meriem., Sabri, Samira., Alsayadi, Muneer M. S. Phytochemical screening and identification of some compounds from mallow. journal of natural product and plant resources, 2012, p. 512–516. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol or water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in seeds

Composition #5: Sabri, Fatima Zohra., Belarbi, Meriem., Sabri, Samira., Alsayadi, Muneer M. S. Phytochemical screening and identification of some compounds from mallow. journal of natural product and plant resources, 2012, p. 512–516. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol or water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in stems

Composition #6: Sabri, Fatima Zohra., Belarbi, Meriem., Sabri, Samira., Alsayadi, Muneer M. S. Phytochemical screening and identification of some compounds from mallow. journal of natural product and plant resources, 2012, p. 512–516. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins in stems

Composition #7: Sabri, Fatima Zohra., Belarbi, Meriem., Sabri, Samira., Alsayadi, Muneer M. S. Phytochemical screening and identification of some compounds from mallow. journal of natural product and plant resources, 2012, p. 512–516. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins in seeds

Composition #8: Sabri, Fatima Zohra., Belarbi, Meriem., Sabri, Samira., Alsayadi, Muneer M. S. Phytochemical screening and identification of some compounds from mallow. journal of natural product and plant resources, 2012, p. 512–516. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins in stems

Composition #9: Terninko, I. I., Onishchenko, U. E., Frolova, A. Research phenolic compounds Malva sylvestris by high performance liquid chromatography. Pharma Innovation, 2014, p. 46–50. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Coumarin (RF-00000370-TOX)
Analytical method code:

HPLC with standard detection methods (F019A)
Result unit:

Milligram/100 gram (G057A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

23.2
Internal remarks:

Coumarin

Composition #10: Emets, T.I., Steblyuk, M.V., Klyuev, N.A., Petrenko, V.V. Some components of the seed oil of Malva sylvestris. Chemistry of Natural Compounds, 1994, vol. 30, no. 3, p. 292–294. DOI: 10.1007/BF00629959. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

cold ethyl ether
Substance:

1,8-cineole (RF-00003470-PAR)
Additional substance description:

1,8-cineole in seed oil
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.23
Internal remarks:

1,8-cineole in seed oil

Composition #11: Emets, T.I., Steblyuk, M.V., Klyuev, N.A., Petrenko, V.V. Some components of the seed oil of Malva sylvestris. Chemistry of Natural Compounds, 1994, vol. 30, no. 3, p. 292–294. DOI: 10.1007/BF00629959. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

cold ethyl ether
Substance:

Camphor (RF-00003986-PAR)
Additional substance description:

Alpha-camphor in seed oil
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.38-0.41
Internal remarks:

Alpha-camphor in seed oil

Composition #12: Veshkurova, Olga., Golubenko, Zamira., Pshenichnov, Egor., Arzanova, Irina., Uzbekov, Vyacheslav., Sultanova, Elvira., Salikhov, Shavkat., Williams, Howard J., Reibenspies, Joseph H., Puckhaber, Lorraine S., Stipanovic, Robert D. Malvone A, a phytoalexin found in Malva sylvestris (family Malvaceae). PHYTOCHEMISTRY, 2006, vol. 67, no. 21, p. 2376–2379. DOI: 10.1016/j.phytochem.2006.08.010. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Acetone
Substance:

Naphthoquinones (RF-00010839-PAR)
Additional substance description:

Malvone A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Malvone A

Composition #13: Daniela, Alesiani., Pichichero, Elena., Canuti, Lorena., Cicconi, Rosella., Karou, Damintoti., D'Arcangelo, Giuseppe., Canini, Antonella. Identification of phenolic compounds from medicinal and melliferous plants and their cytotoxic activity in cancer cells. CARYOLOGIA, 2007, vol. 60, no. 1-2, p. 90–95. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (70%)
Substance:

genistein (RF-00000297-NTR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Genistein

Composition #14: Daniela, Alesiani., Pichichero, Elena., Canuti, Lorena., Cicconi, Rosella., Karou, Damintoti., D'Arcangelo, Giuseppe., Canini, Antonella. Identification of phenolic compounds from medicinal and melliferous plants and their cytotoxic activity in cancer cells. CARYOLOGIA, 2007, vol. 60, no. 1-2, p. 90–95. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (70%)
Substance:

limettin (RF-00011371-PAR)
Additional substance description:

5,7-dimethoxycoumarin
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

5,7-dimethoxycoumarin

Composition #15: Tosi, B., Tirillini, B., Donini, A., Bruni, A. Presence of scopoletin in Malva sylvestris. INTERNATIONAL JOURNAL OF PHARMACOGNOSY, 1995, vol. 33, no. 4, p. 353–355. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH or water
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Result unit:

Microgram/gram (G049A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

10-31
Internal remarks:

Scopoletin