EFSA Compendium of Botanicals

Draft - work in progress

Geranium robertianum L.

Family:: Geraniaceae
Approval state:: Approved
Number of articles retrieved:: 207
Number of processed references:: 6

Compositions

#1: beta-Penta-O-galloyl-D-glucose (gallotannins) #2: Lectins #3: Tannins #4: Tannins #5: Beta-myrcene in essential oil of aerial parts #6: Tannin #7: gallic acid

Endpoint Studies

Genotoxicity

Composition #1: Haddock, Elizabeth A., Gupta, Raj K., Al-Shafi, Sabah M. K., Haslam, Edwin., Magnolato, Daniele. The metabolism of gallic acid and hexahydroxydiphenic acid in plants. Part 1. Introduction. Naturally occurring galloyl esters. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, None, p. 2515–2524. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Gallotannins (RF-00013316-PAR)
Additional substance description:

beta-Penta-O-galloyl-D-glucose
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

beta-Penta-O-galloyl-D-glucose (gallotannins)

Composition #2: Rybak, Lyubov., Rudik, Galina. Research on quantitative content of lectins in plants of the Geranium L. genus. pharma innovation, 2013, p. 38–41. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Lectins (RF-00000439-ORG)
Additional substance description:

Hemagglutination reaction, using a 2% suspension of Group IV (AB) native human red blood cells
Analytical method code:

Hemagglutination inhibition test (F147A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lectins

Composition #3: Piwowarski, J.P., Kiss, A.K., Kozłowska-Wojciechowska, M. Anti-hyaluronidase and anti-elastase activity screening of tannin-rich plant materials used in traditional Polish medicine for external treatment of diseases with inflammatory background. Journal of Ethnopharmacology, 2011, vol. 137, no. 1, p. 937–941. DOI: 10.1016/j.jep.2011.05.039. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Distilled water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

2D TLC, HPLC
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

20.7
Internal remarks:

Tannins

Composition #4: Fodorea, Cristina-Stefania., Vlase, L., Suciu, Simona., Tamas, M., Leucuta, S E. Preliminary HPLC study on some polyphenols of Geranium robertianum L. (Geraniaceae). . revista medico-chirurgicala a societatii de medici si naturalisti din iasi, 2005, vol. 109, no. 1, p. 174–8. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Tannins (RF-00004337-PAR)
Additional substance description:

Ellagic tanninns
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins

Composition #5: Pedro, Luis G., Pais, M. Salome S., Scheffer, Johanna J. C. Composition of the Essential Oil of Geranium robertianum L.. flavour and fragrance journal, 1992, vol. 7, no. 4, p. 223–226. DOI: 10.1002/ffj.2730070410. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.3
Internal remarks:

Beta-myrcene in essential oil of aerial parts

Composition #6: Paun, Gabriela., Litescu, Simona Carmen., Neagu, Elena., Tache, Andreia., Radu, Gabriel Lucian. Evaluation of Geranium spp., Helleborus spp. and Hyssopus spp. polyphenolic extracts inhibitory activity against urease and alpha-chymotrypsin. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2014, vol. 29, no. 1, p. 28–34. DOI: 10.3109/14756366.2012.749399. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Distilled water
Substance:

Tannins (RF-00004337-PAR)
Substance used for equivalence:

tannic acid (RF-00004069-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

HPLC-MS
Result unit:

Microgram/millilitre (G052A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

283.1
Internal remarks:

Tannin

Composition #7: Paun, Gabriela., Litescu, Simona Carmen., Neagu, Elena., Tache, Andreia., Radu, Gabriel Lucian. Evaluation of Geranium spp., Helleborus spp. and Hyssopus spp. polyphenolic extracts inhibitory activity against urease and alpha-chymotrypsin. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2014, vol. 29, no. 1, p. 28–34. DOI: 10.3109/14756366.2012.749399. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Distilled water
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

HPLC-MS
Result unit:

Milligram/kilogram (G061A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1078.8
Internal remarks:

gallic acid