EFSA Compendium of Botanicals

Draft - work in progress

Meadow sweet (as plant) // Filipendula ulmaria (L.) Maxim.

Family:: Rosaceae
Approval state:: Approved
Number of articles retrieved:: 586
Number of processed references:: 7

Compositions

#1: Tannins #2: Methyl salicylate #3: Salicylaldehyde #4: Tellimagrandin I #5: Saponins - flowers #6: Tannins - Leaves #7: Tannins - Flowers #8: Saponins - Leaves #9: P-coumaric acid #10: Salicylic acid #11: salicylaldehyde - aerial parts #12: salicylaldehyde - stem #13: salicylaldehyde - leaves #14: methylsalicylate - flowers #15: methylsalicylate - aerial parts #16: salicylaldehyde - flowers #17: methylsalicylate - leaves #18: methylsalicylate - stem #19: salycilic acid

Endpoint Studies

Genotoxicity

Composition #1: Barnaulov, O. D., Kumkov, A. V., Khalikova, N. A., Kozhina, I. S., Shukhobodskii, B. A. Chemical composition and primary evaluation of the properties of preparations from Filipendula ulmaria (L.) Maxim flowers. rastitel'nye resursy, 1977, p. 661–669. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12.5
Internal remarks:

Tannins

Composition #2: Zykova, I. D., Efremov, A. A. Componental compound of essential oil from inflorescences of Filipendula ulmaria (L) Maxim in during stages of flovering and fruting. khimiya rastitel'nogo syr'ya, 2011, p. 133–136. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

11.2-28.2
Internal remarks:

Methyl salicylate

Composition #3: Zykova, I. D., Efremov, A. A. Componental compound of essential oil from inflorescences of Filipendula ulmaria (L) Maxim in during stages of flovering and fruting. khimiya rastitel'nogo syr'ya, 2011, p. 133–136. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Salicylaldehyde (RF-00008324-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.8-12.4
Internal remarks:

Salicylaldehyde

Composition #4: Moilanen, Johanna., Sinkkonen, Jari., Salminen, Juha-Pekka. Characterization of bioactive plant ellagitannins by chromatographic, spectroscopic and mass spectrometric methods. Chemoecology, 2013, p. 165–179. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone/water (7/3, v/v) with 0.1 % (m/v) ascorbic acid
Substance:

Ellagitannins (hydrolysable tannins) Ellagitannins (hydrolysable tannins) (RF-00004379-PAR)
Additional substance description:

Tellimagrandin I
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

HPLC-DAD
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tellimagrandin I

Composition #5: Vysochina, G. I., Kukushkina, T. A., Shaldaeva, T. M. The content of the main groups of biologically active substances in plants of the Siberian species of Filipendula mill.. khimiya rastitel'nogo syr'ya, 2014, p. 129–135. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3 extract; ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Gravimetric tests (F004A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.0-30.7
Internal remarks:

Saponins - flowers

Composition #6: Vysochina, G. I., Kukushkina, T. A., Shaldaeva, T. M. The content of the main groups of biologically active substances in plants of the Siberian species of Filipendula mill.. khimiya rastitel'nogo syr'ya, 2014, p. 129–135. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water 100°C
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Volumetric tests (F005A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

19.4-28.1
Internal remarks:

Tannins - Leaves

Composition #7: Vysochina, G. I., Kukushkina, T. A., Shaldaeva, T. M. The content of the main groups of biologically active substances in plants of the Siberian species of Filipendula mill.. khimiya rastitel'nogo syr'ya, 2014, p. 129–135. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water 100°C
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Volumetric tests (F005A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

38.3-56.8
Internal remarks:

Tannins - Flowers

Composition #8: Vysochina, G. I., Kukushkina, T. A., Shaldaeva, T. M. The content of the main groups of biologically active substances in plants of the Siberian species of Filipendula mill.. khimiya rastitel'nogo syr'ya, 2014, p. 129–135. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

CHCl3 extract; ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Gravimetric tests (F004A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.6-14.6
Internal remarks:

Saponins - Leaves

Composition #9: Bijttebier, Sebastiaan., Van der Auwera, Anastasia., Voorspoels, Stefan., Noten, Bart., Hermans, Nina., Pieters, Luc., Apers, Sandra. A First Step in the Quest for the Active Constituents in Filipendula ulmaria (Meadowsweet): Comprehensive Phytochemical Identification by Liquid Chromatography Coupled to Quadrupole-Orbitrap Mass Spectrometry. planta medica, 2016 . .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH + ammonium formate buffer at different pH
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

UHPLC-MS-MS (F608A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

31
Internal remarks:

P-coumaric acid

Composition #10: Bijttebier, Sebastiaan., Van der Auwera, Anastasia., Voorspoels, Stefan., Noten, Bart., Hermans, Nina., Pieters, Luc., Apers, Sandra. A First Step in the Quest for the Active Constituents in Filipendula ulmaria (Meadowsweet): Comprehensive Phytochemical Identification by Liquid Chromatography Coupled to Quadrupole-Orbitrap Mass Spectrometry. planta medica, 2016 . .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH + ammonium formate buffer at different pH
Substance:

Salicylic acid (RF-00000241-VET)
Analytical method code:

UHPLC-MS-MS (F608A)
Result unit:

Microgram/gram (G049A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

630
Internal remarks:

Salicylic acid

Composition #11: Papp, Ildiko., Simandi, Bela., Blazics, Balazs., Alberti, Agnes., Hethelyi, Eva., Szoke, Eva., Kery, Agnes. Monitoring Volatile and Non-Volatile Salicylates in Filipendula ulmaria by Different Chromatographic Techniques. CHROMATOGRAPHIA, 2008, vol. 68, p. S125–S129. DOI: 10.1365/s10337-008-0749-5. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Salicylaldehyde (RF-00008324-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

67.5
Internal remarks:

salicylaldehyde - aerial parts

Composition #12: Papp, Ildiko., Simandi, Bela., Blazics, Balazs., Alberti, Agnes., Hethelyi, Eva., Szoke, Eva., Kery, Agnes. Monitoring Volatile and Non-Volatile Salicylates in Filipendula ulmaria by Different Chromatographic Techniques. CHROMATOGRAPHIA, 2008, vol. 68, p. S125–S129. DOI: 10.1365/s10337-008-0749-5. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Salicylaldehyde (RF-00008324-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

16.9
Internal remarks:

salicylaldehyde - stem

Composition #13: Papp, Ildiko., Simandi, Bela., Blazics, Balazs., Alberti, Agnes., Hethelyi, Eva., Szoke, Eva., Kery, Agnes. Monitoring Volatile and Non-Volatile Salicylates in Filipendula ulmaria by Different Chromatographic Techniques. CHROMATOGRAPHIA, 2008, vol. 68, p. S125–S129. DOI: 10.1365/s10337-008-0749-5. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Salicylaldehyde (RF-00008324-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.3
Internal remarks:

salicylaldehyde - leaves

Composition #14: Papp, Ildiko., Simandi, Bela., Blazics, Balazs., Alberti, Agnes., Hethelyi, Eva., Szoke, Eva., Kery, Agnes. Monitoring Volatile and Non-Volatile Salicylates in Filipendula ulmaria by Different Chromatographic Techniques. CHROMATOGRAPHIA, 2008, vol. 68, p. S125–S129. DOI: 10.1365/s10337-008-0749-5. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=23.9
Internal remarks:

methylsalicylate - flowers

Composition #15: Papp, Ildiko., Simandi, Bela., Blazics, Balazs., Alberti, Agnes., Hethelyi, Eva., Szoke, Eva., Kery, Agnes. Monitoring Volatile and Non-Volatile Salicylates in Filipendula ulmaria by Different Chromatographic Techniques. CHROMATOGRAPHIA, 2008, vol. 68, p. S125–S129. DOI: 10.1365/s10337-008-0749-5. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.6
Internal remarks:

methylsalicylate - aerial parts

Composition #16: Papp, Ildiko., Simandi, Bela., Blazics, Balazs., Alberti, Agnes., Hethelyi, Eva., Szoke, Eva., Kery, Agnes. Monitoring Volatile and Non-Volatile Salicylates in Filipendula ulmaria by Different Chromatographic Techniques. CHROMATOGRAPHIA, 2008, vol. 68, p. S125–S129. DOI: 10.1365/s10337-008-0749-5. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Salicylaldehyde (RF-00008324-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<=7.3
Internal remarks:

salicylaldehyde - flowers

Composition #17: Papp, Ildiko., Simandi, Bela., Blazics, Balazs., Alberti, Agnes., Hethelyi, Eva., Szoke, Eva., Kery, Agnes. Monitoring Volatile and Non-Volatile Salicylates in Filipendula ulmaria by Different Chromatographic Techniques. CHROMATOGRAPHIA, 2008, vol. 68, p. S125–S129. DOI: 10.1365/s10337-008-0749-5. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

39.1
Internal remarks:

methylsalicylate - leaves

Composition #18: Papp, Ildiko., Simandi, Bela., Blazics, Balazs., Alberti, Agnes., Hethelyi, Eva., Szoke, Eva., Kery, Agnes. Monitoring Volatile and Non-Volatile Salicylates in Filipendula ulmaria by Different Chromatographic Techniques. CHROMATOGRAPHIA, 2008, vol. 68, p. S125–S129. DOI: 10.1365/s10337-008-0749-5. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

81.9
Internal remarks:

methylsalicylate - stem

Composition #19: Harbourne, Niamh., Jacquier, Jean Christophe., O'Riordan, Dolores. Optimisation of the aqueous extraction conditions of phenols from meadowsweet (Filipendula ulmaria L.) for incorporation into beverages . food chemistry, 2009, vol. 116, no. 3, p. 722–727. DOI: 10.1016/j.foodchem.2009.03.017. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Water at 60-100°C
Substance:

Salicylic acid (RF-00000241-VET)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.39 - 0.46
Internal remarks:

salycilic acid