EFSA Compendium of Botanicals

Draft - work in progress

Bupleurum falcatum L.

Family:: Apiaceae (Umbelliferae)
Approval state:: Approved
Number of articles retrieved:: 797
Number of processed references:: 2

Compositions

Endpoint Studies

#1: Hepatotoxicity - Histological examinations demon-strated apparent loss of integrated shape and regular arrangementof hepatocytes in the liver of SSD-treated mice, suggesting mas-sive hepatocyte death

Genotoxicity

Composition #1: Lee, Jaehyun., Yang, Dong-Hyug., Suh, Joon Hyuk., Kim, Unyong., Eom, Han Young., Kim, Junghyun., Lee, Mi Young., Kim, Jinwoong., Han, Sang Beom. Species discrimination of Radix Bupleuri through the simultaneous determination of ten saikosaponins by high performance liquid chromatography with evaporative light scattering detection and electrospray ionization mass spectrometry. AND LIFE SCIENCES, 2011, vol. 879, no. 32, p. 3887–3895. DOI: 10.1016/j.jchromb.2011.10.040. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol, methanol
Substance:

saikosaponins (RF-00010819-PAR)
Additional substance description:
Analytical method code:

HPLC-ELSD (F327A)
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.81-7.85
Internal remarks:

Saikosaponins

Endpoint study #1: Zhang, Feng., Chen, Li., Jin, Huanhuan., Shao, Jiangjuan., Wu, Li., Lu, Yin., Zheng, Shizhong. Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2016, vol. 41, p. 8–13. DOI: 10.1016/j.etap.2015.11.005. [DOI link]

Study relevance:

Human health
Substance:

Saikosaponin D (RF-00010946-PAR)
Type of toxicological test:

other (CHD008TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

1.0
Unit of exposure duration:

Week (G205A)
Number of organisms dosed:

20
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram/kilogram (G061A)
Effect concentration:

330
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

urogenital: Urinary Bladder (TT051A)
Effect description:

Histological examinations demon-strated apparent loss of integrated shape and regular arrangementof hepatocytes in the liver of SSD-treated mice, suggesting massive hepatocyte death
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Hepatotoxicity - Histological examinations demon-strated apparent loss of integrated shape and regular arrangementof hepatocytes in the liver of SSD-treated mice, suggesting mas-sive hepatocyte death