EFSA Compendium of Botanicals

Draft - work in progress

Baccharis coridifolia DC.

Family:: Asteraceae (Compositae)
Approval state:: Approved
Number of articles retrieved:: 90
Number of processed references:: 7

Compositions

#1: trichothecenes accumulated and metabolised by symbiosis (roridin A and E; miotoxins A-D; di-0-acetyl -verrucarol) #2: naphthalene derivative (beta-selinene) #3: trichothecenes

Endpoint Studies

#1: acute toxicity in horses #2: Acute toxicity in rabbit. #3: Case report, death of grazing cattle #4: lethal dose on sheeps

Genotoxicity

Composition #1: Habermehl, G. Isolation and structure of new toxins from plants. Pure and Applied Chemistry, 1989, vol. 61, no. 3, p. 377–380. DOI: 10.1351/pac198961030377. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform
Substance:

Mycotoxins Mycotoxins (RF-00000132-TOX)
Additional substance description:

roridin A and E; miotoxins A-d; di-O-acetyl-verrucarol (trichothecenes)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

trichothecenes accumulated and metabolised by symbiosis (roridin A and E; miotoxins A-D; di-0-acetyl -verrucarol)

Composition #2: Bailac, PN., Dellacasa, AD., Bernasconi, HO., Ponzi, MI., Firpo, NH. Essential oil of female plants of Baccharis coridifolia De Candole. JOURNAL OF ESSENTIAL OIL RESEARCH, 2001, vol. 13, no. 1, p. 23–24. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydro distillation
Substance:

beta-selinene (RF-00011306-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.2
Internal remarks:

naphthalene derivative (beta-selinene)

Composition #3: Tokarnia, CH., Dobereiner, H., Peixoto, PV. Poisonous plants affecting livestock in Brazil. TOXICON, 2002, vol. 40, no. 12, p. 1635–1660. DOI: 10.1016/S0041-0101(02)00239-8. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Substance:

Mycotoxins Mycotoxins (RF-00000132-TOX)
Additional substance description:

roridin A and E (trichothecenes)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

trichothecenes

Endpoint study #1: Costa, Elizabeth Ramalho., Costa, Joselito Nunes., Armien, Anibal Guillermo., Barbosa, Jose Diomedes., Peixoto, Paulo Vargas. Experimental poisoning in horses by Baccharis coridifolia (Compositae). pesquisa veterinaria brasileira, 1995, vol. 15, no. 1, p. 19–26. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Additional plant/substance description:

fresh flowering and seeding Baccharis coridifolia DC
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

Horse (as animal) (A0B9Z)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

5
Control groups used:

no
Endpoint measured:

Lowest lethal dose (CHD025EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

0.125
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

anorexia, abdominal pain, diarrhoea, fever, dehydration, polydipsia, tachycardia, tachyphigmia, tachypnoea, dyspnoea, restlesness, locomotor instability and death
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

acute toxicity in horses

Endpoint study #2: Rodrigues, Rosaura Leite., Tokarnia, Carlos Hubinger. Factors which influence the toxicity of Baccharis coridifolia (Compositae): An experimental study in rabbits . pesquisa veterinaria brasileira, 1995, vol. 15, no. 2-3, p. 51–69. .

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Drying (dehydration) (A07KG)
Additional plant/substance description:

aqeous suspension
Type of toxicological test:

case report (CHD060TT)
Limit test:

Not applicable
Tested organism:

Rabbit (as animal) (A057T)
Sex:

No data
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Number of organisms dosed:

49
Control groups used:

yes
Endpoint measured:

Lowest lethal dose (CHD025EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

0.17
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

hemorrhagic necrosis stomach, caecum, swelling and vacuolisation liver
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Acute toxicity in rabbit.

Endpoint study #3: Lértora1, W.J., Negrette, M.S. Baccharis coridifolia poisoning in water buffalo (bubalus bubalis) in the north of the province of Corrientes, Argentina. Brazilian Journal of Veterinary Pathology, 2015, vol. 8, no. 1, p. 1–5. .

Study relevance:

Human health
Plant part:

Live plants (as part-nature) (A0BA0)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cattle (as animal) (A057E)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

57
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

SYSTEMIC (TOX01A)
Effect description:

necrosis of the epithelium of the mucosa of the forestomachs, necrosis and hemorrhage in mucosa of the small intestine, necrosis of lymphocytes in lymph follicles in spleen and thymus and vasogenic brain edema
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Case report, death of grazing cattle

Endpoint study #4: Cid, MS., Lopez, TA., Yagueddu, C., Brizuela, MA. Acute toxic plant estimation in grazing sheep ingesta and feces. JOURNAL OF RANGE MANAGEMENT, 2003, vol. 56, no. 4, p. 353–357. DOI: 10.2307/4004038. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Limit test:

Not applicable
Tested organism:

Sheep (as animal) (A057G)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Control groups used:

no
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Gram (G148A)
Effect concentration:

42.0
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Stomach (TT027A)
Effect description:

lethal dose = 42 grams
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

lethal dose on sheeps