EFSA Compendium of Botanicals

Draft - work in progress

Akebia trifoliata (Thunb.) Koidz.

Family:: Lardizabalaceae
Approval state:: Approved
Number of articles retrieved:: 345
Number of processed references:: 2

Compositions

Endpoint Studies

#1: A few endothelial cell degenerations in renal glomerulus were observed in the Akebia trifoliate group at a high-dose of 2.00 g/kg/d. NOAEL: 0.4 g/kg

Genotoxicity

Composition #1: Mimaki, Y., Kuroda, M., Yokosuka, A., Harada, H., Fukushima, M., Sashida, Y. Triterpenes and triterpene saponins from the stems of Akebia trifoliata. chemical & pharmaceutical bulletin, 2003, vol. 51, no. 8, p. 960–965. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pentacyclic triterpene saponins

Endpoint study #1: Xue, Xiang., Xiao, Ying., Gong, Likun., Guan, Shuhong., Liu, Yongzhen., Lu, Henglei., Qi, Xinming., Zhang, Yunhai., Li, Yan., Wua, Xiongfei., Ren, Jin. Comparative 28-day repeated oral toxicity of Longdan Xieganwan, Akebia trifoliate (Thunb.) koidz., Akebia quinata (Thunb.) Decne. and Caulis aristolochiae manshuriensis in mice. JOURNAL OF ETHNOPHARMACOLOGY, 2008, vol. 119, no. 1, p. 87–93. DOI: 10.1016/j.jep.2008.05.037. [DOI link]

Study relevance:

Human health
Plant part:

Stem / stalk (as part-nature) (A067S)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water extract
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

110
Control groups used:

yes
Endpoint measured:

No observed adverse effect level (CHD010EP)
Concentration unit:

Gram/kilogram (G015A)
Effect concentration:

0.4
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

A few endothelial cell degenerations in renal glomerulus at a high-dose of 2.00 g/kg/d
Effect or parameter linked to the endpoint:

urinalysis (CHD029BE)
Internal remarks:

A few endothelial cell degenerations in renal glomerulus were observed in the Akebia trifoliate group at a high-dose of 2.00 g/kg/d. NOAEL: 0.4 g/kg