EFSA Compendium of Botanicals

Draft - work in progress

Achyrocline satureioides (Lam.) DC.

Family:: Asteraceae (Compositae)
Approval state:: Approved
Number of articles retrieved:: 231
Number of processed references:: 3

Compositions

Endpoint Studies

Genotoxicity

#1: A. satureoides extracts are mutagenic and potentially carcinogenic. #2: The physiological aberrations observed were c-mitosis and sticky and delayed chromosomes, whereas the clastogenic aberrations were chromosomal bridges. No clinical signs of behavioral toxicity or mortality were observed in the animals treated with extract at every concentration

Composition #1: Lamaty, G., Menut, C., Bessière, J.-M., Schenkel, E.P., dos Santos, M.A., Bassani, V. The chemical composition of some Achyrocline satureioides and Achyrocline alata oils from Brazil. journal of essential oil research, 1991, vol. 3, no. 5, p. 317–321. DOI: 10.1080/10412905.1991.9697951. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12
Internal remarks:

1,8-cineole

Genotox #1: Vargas, Vera Maria Ferrao., Motta, V. E. P., Leitao, A. C., Henriques, J. A. P. Mutagenic and genotoxic effects of aqueous extracts of Achyrocline satureoides in prokaryotic organisms. Mutation Research, Genetic Toxicology Testing, 1990, p. 13–18. .

Study category:

Genotoxicity
Type of toxicological test:

SOS/umu test (CHD035TT)
Method type:

in vitro
Guideline used:

According to
Tested organism:

Salmonella typhimurium (as organism) (A0CPZ)
Strain of test organism:

TA 1535, TA 1537, TA 98, TA 100 and TA 102 (CHD039ST)
Sex:

No data
Route of exposure:

OTHER (OECD0PL)
Control groups used:

yes
Endpoint measured:

gene mutation
Is genotoxic:

Positive
Remarks on genotox study:

A. satureoides extracts are mutagenic and potentially carcinogenic.
Internal remarks:

A. satureoides extracts are mutagenic and potentially carcinogenic.
Internal ID:

CAPLUS_1990:93402

Genotox #2: Cariddi, L N., Sabini, M C., Escobar, F M., Bacchetti, R., Montironi, I., Merckis, C., Reinoso, E B., Nunez Montoya, S., Zanon, S M., Comini, L R., Sabini, L I. In Vitro and In Vivo Cytogenotoxic Effects of Hot Aqueous Extract of Achyrocline satureioides (Lam.) DC.. BioMed research international, 2015, vol. 2015, p. 270973–270973. DOI: 10.1155/2015/270973. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

micronucleus assay (CHD051TT)
Method type:

in vitro
Guideline used:

According to
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male/Female
Exogenous metabolic activation applied:

no data
Route of exposure:

OTHER (OECD0PL)
Number of organisms dosed:

6
Control groups used:

yes
Endpoint measured:

chromosome aberration
Is genotoxic:

Negative
Remarks on genotox study:

The physiological aberrations observed were c-mitosis and sticky and delayed chromosomes, whereas the clastogenic aberrations were chromosomal bridges.
Internal remarks:

The physiological aberrations observed were c-mitosis and sticky and delayed chromosomes, whereas the clastogenic aberrations were chromosomal bridges. No clinical signs of behavioral toxicity or mortality were observed in the animals treated with extract at every concentration
Internal ID:

MEDLINE:26078941