EFSA Compendium of Botanicals

Draft - work in progress

Zygophyllum fabago L.

Family:: Zygophyllaceae
Approval state:: Approved
Number of articles retrieved:: 111
Number of processed references:: 7

Compositions

#1: harman in roots #2: total alkaloids in roots #3: saponins, quantitative #4: Phenylpropanoid ("fabagoin B") #5: pentacyclic triterpene saponins (zygophylloside C and D), root #6: Pentacyclic triterpene saponins (zygophyloside O and P, bark) #7: pentacyclic triterpene saponins (Zygophyloside Q and R), bark #8: Pentacyclic triterpene saponins (zygofaboside A, E and G) aerial parts

Endpoint Studies

Genotoxicity

Composition #1: Borkowski, Boguslaw. Chromatographic determination of alkaloids in Zygophyllum fabago. biuletyn instytutu roslin leczniczych, 1959, p. 158–168. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

Unspecified
Substance:

harman (RF-00003852-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.014
Internal remarks:

harman in roots

Composition #2: Borkowski, Boguslaw. Chromatographic determination of alkaloids in Zygophyllum fabago. biuletyn instytutu roslin leczniczych, 1959, p. 158–168. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

Unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Total alkaloids
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.058
Internal remarks:

total alkaloids in roots

Composition #3: Fatkulin, A. G., Abramov, M. M., Otroshchenko, O. S., Sadykov, A. S. Chemical composition of Zygophyllum fabago. trudy samarkandskogo gosudarstvennogo universiteta imeni alishera navoi, 1969, p. 147–153. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

Unspecified
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Gram/kilogram (G015A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

120
Internal remarks:

saponins, quantitative

Composition #4: He, Jiangbo., Lv, Xiaoman., Niu, Yanfen., Tao, Jian., Wang, Bo., Jia, Jing., Chen, Weiwei. Four new compounds from Zygophyllum fabago L.. phytochemistry letters, 2016, p. 116–120. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

phenylpropanoids (RF-00004367-PAR)
Additional substance description:

"fabagoin B"
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR, HREIMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Phenylpropanoid ("fabagoin B")

Composition #5: Kerimova, Kh.M., Pkheidze, T.A., Gorovits, T.T. Triterpene saponins of Zygophyllum fabago. Chemistry of Natural Compounds, 1971, vol. 7, no. 4, p. 521–None. DOI: 10.1007/BF00564773. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

various types of extracts
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Zygophylloside C and D
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

spectrometric methods
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pentacyclic triterpene saponins (zygophylloside C and D), root

Composition #6: Feng, Yu-Lin., Wu, Bei., Li, He-Ran., Li, Yun-Qiu., Xu, Li-Zhen., Yang, Shi-Lin., Kitanaka, Susumu. Triterpenoidal saponins from the barks of Zygophyllum fabago L.. CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, vol. 56, no. 6, p. 858–860. DOI: 10.1248/cpb.56.858. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extraction
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Zygophyloside O and P
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pentacyclic triterpene saponins (zygophyloside O and P, bark)

Composition #7: Feng, Yu-Lin., Li, He-Ran., Rao, Yi., Luo, Xiao-Jian., Xu, Li-Zhen., Wang, Yue-Sheng., Yang, Shi-Lin., Kitanaka, Susumu. Two Sulfated Triterpenoidal Saponins from the Barks of Zygophyllum fabago L.. CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, vol. 57, no. 6, p. 612–614. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extraction
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

zygophyloside Q and R
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

pentacyclic triterpene saponins (Zygophyloside Q and R), bark

Composition #8: Khan, Saleha Suleman., Khan, Ajmal., Khan, Afsar., Wadood, Abdul., Farooq, Umar., Ahmed, Amir., Zahoor, Aqib., Ahmad, Viqar Uddin., Sener, Bilge., Erdemoglu, Nurgun. Urease inhibitory activity of ursane type sulfated saponins from the aerial parts of Zygophyllum fabago Linn. PHYTOMEDICINE, 2014, vol. 21, no. 3, p. 379–382. DOI: 10.1016/j.phymed.2013.09.009. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol extraction
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

zygofaboside A, E and G
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pentacyclic triterpene saponins (zygofaboside A, E and G) aerial parts