EFSA Compendium of Botanicals

Draft - work in progress

Zanthoxylum acanthopodium DC.

Family:: Rutaceae
Approval state:: Approved
Number of articles retrieved:: 53
Number of processed references:: 5

Compositions

#1: lignans (sesamin, episeamin, eudesmin, epieudesmin, fargesin), stem #2: Skimmianine (root) #3: Coumarins (aesculetin dimethylether), root #4: dictamnine in root #5: lignans (sesamin) root #6: lignan (sesamin) leaves #7: Hydroquinone (essential oil, leaves, quantified) #8: 1,8-cineole (essential oil, leaves, quantified)

Endpoint Studies

Genotoxicity

Composition #1: Pelter, Andrew., Ward, Robert S., Rao, E. Venkata., Sastry, K. V. Revised structures for pluviatilol, methyl pluviatilol, and xanthoxylol. General methods for the assignment of stereochemistry to 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane lignans. Tetrahedron, 1976, p. 2783–2788. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

sesamin, episeamin, eudesmin, epieudesmin, fargesin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

NMR, IR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignans (sesamin, episeamin, eudesmin, epieudesmin, fargesin), stem

Composition #2: Ren, Lijuan., Xie, Fengzhi., Xue, Zhi. Chemical constituents of Himalaya prickly ash root (Zanthoxylum acanthopodium radix). zhongcaoyao, 1986, p. 193–196. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

skimmianine (RF-00004057-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Skimmianine (root)

Composition #3: Ren, Lijuan., Xie, Fengzhi., Xue, Zhi. Chemical constituents of Himalaya prickly ash root (Zanthoxylum acanthopodium radix). zhongcaoyao, 1986, p. 193–196. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

Unspecified
Substance:

Esculetin (RF-00003667-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

IR, NMR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins (aesculetin dimethylether), root

Composition #4: Yang, Min., Luo, Shide. Chemical constituents of Yan-jiao (Zanthoxylum acanthopodium). zhongcaoyao, 1989, p. 441–443. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

Unspecified
Substance:

dictamnine (RF-00003774-PAR)
Additional substance description:

dictamnine and derivatives
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dictamnine in root

Composition #5: Yang, Min., Luo, Shide. Chemical constituents of Yan-jiao (Zanthoxylum acanthopodium). zhongcaoyao, 1989, p. 441–443. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

Unspecified
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

sesamin
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignans (sesamin) root

Composition #6: Sukari, Mohd. Aspollah., Rahmani, Mawardi., Choo, N. G. Beng., Haron, M. D. Jelas., Ali, Jambari H., Ahmad, Faujan B. H. Chemical constituents of the leaves of Zanthoxylum acanthopodium and its biological activity. oriental journal of chemistry, 1996, p. 135–136. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

sesamin
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignan (sesamin) leaves

Composition #7: Rana, Virendra S., Amparo Blazquez, M. Terpenoid Constituents of Zanthoxylum acanthopodium DC. Leaves. journal of essential oil research, 2008, vol. 20, no. 6, p. 515–516. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Hydroquinone (RF-00007127-PAR)
Analytical method code:

GC-FID-MS (F607A)
Result unit:

Percent Area (G139A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.8
Internal remarks:

Hydroquinone (essential oil, leaves, quantified)

Composition #8: Rana, Virendra S., Amparo Blazquez, M. Terpenoid Constituents of Zanthoxylum acanthopodium DC. Leaves. journal of essential oil research, 2008, vol. 20, no. 6, p. 515–516. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-FID-MS (F607A)
Result unit:

Percent Area (G139A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.7
Internal remarks:

1,8-cineole (essential oil, leaves, quantified)