EFSA Compendium of Botanicals

Draft - work in progress

Dolomiaea souliei (Franch.) C.Shih // Vladimiria souliei (Franch.) Ling

Family:: Asteraceae (Compositae)
Approval state:: Approved
Number of articles retrieved:: 47
Number of processed references:: 11

Compositions

#1: dehydrocostus lactone #2: costunolide (sesquiterpene lactone) #3: dehydrocostus lactone (sequiterpene lactone) #4: costunolide #5: deydrocostus lactone #6: costunolide (sesquiterpene lactone) #7: dehydrocostus laton (sesquiterpene lactone) #8: Sesquiterpene lactones #9: emodin ( purgative resin) #10: carabrane-type sesquiterpene #11: sesquiterpene lactone type eudesmanolide #12: dolomiaeasin A and B #13: 2-furoic acid #14: Emodin #15: Sesquiterpene lactones #16: germacranolide-type sesquiterpene lacones #17: vladinol A to F

Endpoint Studies

Genotoxicity

Composition #1: Li, ZhaoLin., Xue, Dunyuan., Wang, Mingkui., Chen, Yaozu. Chemical constituents of volatile oil of Vladimiria soulier (Franch.) Ling. Lanzhou Daxue Xuebao, Ziran Kexueban, 1991, p. 94–97. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

dehydrocostus lactone (RF-00003766-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dehydrocostus lactone

Composition #2: He, Zhiyuan., Fu, Dayou., Wang, Hairong., Yang, Shengdan., Tan, Wenyuan. Study on microwave extraction of costunolide and dehydrocostuslactone from Radix Vladimiriae. Yingyong Huagong, 2009, p. 878–879. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

costunolide (RF-00003753-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

costunolide (sesquiterpene lactone)

Composition #3: He, Zhiyuan., Fu, Dayou., Wang, Hairong., Yang, Shengdan., Tan, Wenyuan. Study on microwave extraction of costunolide and dehydrocostuslactone from Radix Vladimiriae. Yingyong Huagong, 2009, p. 878–879. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

dehydrocostus lactone (RF-00003766-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dehydrocostus lactone (sequiterpene lactone)

Composition #4: Mao, Qian., Fu, Chaomei., Hu, Huiling., Wang, Zhanguo., He, Yao., Bao, Xifu. Study on stability of major pharmaceutical ingredients of Vladimiriae Radix before and after being roasted in artificial gastric juice, artificial intestinal juice and isolated rat gastric, intestinal or colonic incubation juice. Zhongguo Zhongyao Zazhi, 2012, p. 785–789. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

costunolide (RF-00003753-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

costunolide

Composition #5: Mao, Qian., Fu, Chaomei., Hu, Huiling., Wang, Zhanguo., He, Yao., Bao, Xifu. Study on stability of major pharmaceutical ingredients of Vladimiriae Radix before and after being roasted in artificial gastric juice, artificial intestinal juice and isolated rat gastric, intestinal or colonic incubation juice. Zhongguo Zhongyao Zazhi, 2012, p. 785–789. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

dehydrocostus lactone (RF-00003766-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

deydrocostus lactone

Composition #6: Hu, Yi-jie., Liu, Shuang., Deng, Li-na., Chen, Min. HPLC fingerprint and determination method of herbal Vladimiria souliei (Franch.) Ling. Yaowu Fenxi Zazhi, 2015, p. 1946–1952. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

costunolide (RF-00003753-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

costunolide (sesquiterpene lactone)

Composition #7: Hu, Yi-jie., Liu, Shuang., Deng, Li-na., Chen, Min. HPLC fingerprint and determination method of herbal Vladimiria souliei (Franch.) Ling. Yaowu Fenxi Zazhi, 2015, p. 1946–1952. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

dehydrocostus lactone (RF-00003766-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dehydrocostus laton (sesquiterpene lactone)

Composition #8: Wei, Hu., He, Chunnian., Peng, Yong., Ma, Guoxu., Xiao, Peigen. [Chemical constituents of Dolomiaea souliei].. Chinese materia medica, 2012, vol. 37, no. 9, p. 1249–53. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

Costunolide, dehydrocostus lactone, makko lactone, reynosin, santamarine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones

Composition #9: Wei, Hu., He, Chunnian., Peng, Yong., Ma, Guoxu., Xiao, Peigen. [Chemical constituents of Dolomiaea souliei].. Chinese materia medica, 2012, vol. 37, no. 9, p. 1249–53. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Emodin (RF-00003798-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

emodin ( purgative resin)

Composition #10: Xu, Jing., Zhang, Peng., Ma, Zhongjun., Guo, Yuanqiang., Zhao, Xiaojun., Wei, Kun. Two carabrane-type sesquiterpenes from Vladimiria souliei. PHYTOCHEMISTRY LETTERS, 2009, vol. 2, no. 4, p. 204-206. DOI: 10.1016/j.phytol.2009.08.001. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

roots dryied to powder and extracted with methanol
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

carabrane-type sesquiterpene
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

carabrane-type sesquiterpene

Composition #11: Xu, Jing., Zha, Xiaojun., Guo, Yuan Qiang., Zhang, Shuzhong. A novel sesquiterpene from the roots of Vladimiria souliei. PHARMAZIE, 2009, vol. 64, no. 9, p. 623-624. DOI: 10.1691/ph.2009.9588. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction, HPLC separation
Substance:

sesquiterpene lactones type eudesmanolide sesquiterpene lactones type eudesmanolide (RF-00004395-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sesquiterpene lactone type eudesmanolide

Composition #12: Wei, Hua., He, Chunnian., Peng, Yong., Zhang, Sen., Chen, Xiaoguang., Xiao, Peigen. Two New Aryltetralin Lignans from the Roots of Dolomiaea souliei. MOLECULES, 2012, vol. 17, no. 5, p. 5544–5549. DOI: 10.3390/molecules17055544. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70% ethanol
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

dolomiaeasin A and B (aryltetralin-type lignans)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, 1D, 2D NMR and HR-ESI-MS experiments
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

dolomiaeasin A and B

Composition #13: Fan, Gai-Xia., Dong, Le-Le., Li, Hui-Hong., Li, Zheng-Yu., Zhang, Zhan-Xin., Fei, Dong-Qing. Sesquiterpenoids and Other Chemical Components from the Roots of Dolomiaea souliei. CHEMISTRY OF NATURAL COMPOUNDS, 2016, vol. 52, no. 4, p. 754–757. DOI: 10.1007/s10600-016-1766-5. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

2-furoic acid
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

2-furoic acid

Composition #14: Fan, Gai-Xia., Dong, Le-Le., Li, Hui-Hong., Li, Zheng-Yu., Zhang, Zhan-Xin., Fei, Dong-Qing. Sesquiterpenoids and Other Chemical Components from the Roots of Dolomiaea souliei. CHEMISTRY OF NATURAL COMPOUNDS, 2016, vol. 52, no. 4, p. 754–757. DOI: 10.1007/s10600-016-1766-5. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Emodin (RF-00003798-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Emodin

Composition #15: Fan, Gai-Xia., Dong, Le-Le., Li, Hui-Hong., Li, Zheng-Yu., Zhang, Zhan-Xin., Fei, Dong-Qing. Sesquiterpenoids and Other Chemical Components from the Roots of Dolomiaea souliei. CHEMISTRY OF NATURAL COMPOUNDS, 2016, vol. 52, no. 4, p. 754–757. DOI: 10.1007/s10600-016-1766-5. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

arbusculin A, costunolide, dehydrocostus lactone, reynosin, santamarine, 4-epi-arbusculin A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Sesquiterpene lactones

Composition #16: TAN, RX., JAKUPOVIC, J., BOHLMANN, F., JIA, ZJ., SCHUSTER, A. SESQUITERPENE LACTONES FROM VLADIMIRIA-SOULIEI. PHYTOCHEMISTRY, 1990, vol. 29, no. 4, p. 1209-1212. DOI: 10.1016/0031-9422(90)85430-N. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

7 germacranolide-type sesquiterpene lactones
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

germacranolide-type sesquiterpene lacones

Composition #17: TAN, RX., JAKUPOVIC, J., JIA, ZJ. AROMATIC CONSTITUENTS FROM VLADIMIRIA-SOULIEI. PLANTA MEDICA, 1990, vol. 56, no. 5, p. 475-477. DOI: 10.1055/s-2006-961015. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol extraction, HPLC separation
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

vladinol A to F
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

vladinol A to F