EFSA Compendium of Botanicals

Draft - work in progress

Blueberry, highbush (as plant) // Vaccinium corymbosum L.

Family:: Ericaceae
Approval state:: Approved
Number of articles retrieved:: 2278
Number of processed references:: 2

Compositions

Endpoint Studies

Genotoxicity

#1: The MN assay of V. corymbosum hydroalcoholic extract of fruits revealed increased percentage of micronucleated polychromatic erythrocytes .

Composition #1: Wang, Li-Siu., Hecht, Stephen., Carmella, Steven., Seguin, Claire., Rocha, Claudio., Yu, Nanxiong., Stoner, Kristen., Chiu, Steven., Stoner, Gary. Berry Ellagitannins May Not Be Sufficient for Prevention of Tumors in the Rodent Esophagus . journal of agricultural and food chemistry, 2010, vol. 58, no. 7, p. 3992–3995. DOI: 10.1021/jf9030635. [DOI link]

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Ellagitannins (hydrolysable tannins) Ellagitannins (hydrolysable tannins) (RF-00004379-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ellagitannins

Genotox #1: Freitas, Patricia Scotini., de Andrade, Sergio Faloni., Maistro, Edson Luis. Evaluation of the in vivo mutagenic potential of hydroalcoholic extracts of the northern highbush blueberry (Vaccinium corymbosum L. Ericales, Ericaceae) on peripheral blood cells of Swiss mice (Mus musculus Rodentia, Muridae) . genetics and molecular biology, 2008, vol. 31, no. 2, p. 555–560. DOI: 10.1590/S1415-47572008000300025. [DOI link]

Study category:

Mutagenicity
Type of toxicological test:

micronucleus assay (CHD051TT)
Method type:

in vivo
Guideline used:

According to
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

No data
Exogenous metabolic activation applied:

no data
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Number of organisms dosed:

6
Control groups used:

yes
Endpoint measured:

chromosome aberration
Is genotoxic:

Positive
Remarks on genotox study:

The MN assay of V. corymbosum extract revealed that for all the doses tested the micronucleated polychromatic erythrocytes (MNPCE) frequency was increased and, in most cases, doubled
Internal remarks:

The MN assay of V. corymbosum hydroalcoholic extract of fruits revealed increased percentage of micronucleated polychromatic erythrocytes .
Internal ID:

WOS:000256957500025