Draft - work in progress
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- Uncaria gambir (Hunter) Roxb.
Uncaria gambir (Hunter) Roxb.
- Family:
- Rubiaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 121
- Number of processed references:
- 6
Composition #1: Hathway, D. E., Seakins, J. W. T. Enzymic oxidation of catechin to a polymer structurally related to some phlobatannins. Biochemical Journal, 1957, p. 239–245. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ether + ethyl acetate
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Substance:
phlobotannins (RF-00011481-PAR)
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
phlobotannins in leaves
Composition #2: Taylor, William Irving., Hamet, Raymond. Ourouparine, an alkaloid of Ourouparia gambir. comptes rendus des seances de l'academie des sciences, serie d: sciences naturelles, 1966, p. 1141–1143. .
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Unspecified
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
Ourouparine
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Ourouparine
Composition #3: Merlini, Lucio., Mondelli, Rosanna., Nasini, Gianluca., Hesse, Manfred. Gambirine, a new indole alkaloid from Uncaria gambier. Tetrahedron Letters, 1967, p. 1571–1575. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Methanol
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Substance:
indole alkaloids (RF-00004503-PAR)
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Additional substance description:
gambirine
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Analytical method - additional description:
UV Spectroscopy, NMR, MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Indole alkaloids (gambirine)
Composition #4: Merlini, Lucio., Mondelli, R., Nasini, Gianluca., Hesse, M. Structure of roxburghines A-E, new indole alkaloids from an Uncaria Sp. Tetrahedron, 1970, p. 2259–2279. .
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Plant part:
Leaves (as part-nature) (A0EKT)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ehter + methanol
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Substance:
indole alkaloids (RF-00004503-PAR)
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Additional substance description:
Roxburghines A to E
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
UV, IR, MS and TLC
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Result unit:
Milligram/kilogram (G061A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
120
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Internal remarks:
Indole alkaloids (roxburghines A to E)
Composition #5: CHAN, KC. GAMBIRDINE AND ISOGAMBIRDINE ALKALOIDS FROM UNCARIA GAMBIR (HUNT) ROXB. TETRAHEDRON LETTERS, 1968, no. 30, p. 3403–&. .
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Methanol
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Substance:
indole alkaloids (RF-00004503-PAR)
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Additional substance description:
Gambirdine and isogambirdine
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Gambirdine and isogambirdine in stems
Endpoint study
#1: Apea-Bah, F. B., Hanafi, M., Dewi, R. T., Fajriah, S., Darwaman, A., Artanti, N., Lotulung, P., Ngadymang, P., Minarti, B. Assessment of the DPPH and alpha-glucosidase inhibitory potential of gambier and qualitative identification of major bioactive compound . journal of medicinal plants research, 2009, vol. 3, no. 10, p. 736–757. .
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Study relevance:
Human health
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
ethanol
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Type of toxicological test:
in vitro (CHD061TT)
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Endpoint measured:
Half maximal inhibitory concentration (CHD021EP)
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Concentration unit:
Microgram/millilitre (G052A)
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Effect concentration:
15.16
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
alpha-glucosidase inhibition
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
alpha-glucosidase inhibition (IC50)
