EFSA Compendium of Botanicals

Draft - work in progress

Tulipa gesneriana L.

Family:: Liliaceae
Approval state:: Approved
Number of articles retrieved:: 502
Number of processed references:: 3

Compositions

#1: agglutinin (lectins) in bulb

Endpoint Studies

#1: case report of cattle death following bulb ingestion

Genotoxicity

#1: bulbs activate promutagen DMBA

Composition #1: Nakajima, K., Kinoshita, M., Oda, Y., Masuko, T., Kaku, H., Shibuya, N., Kakehi, K. Screening method of carbohydrate-binding proteins in biological sources by capillary affinity electrophoresis and its application to determination of Tulipa gesneriana agglutinin in tulip bulbs. GLYCOBIOLOGY, 2004, vol. 14, no. 9, p. 793–804. DOI: 10.1093/qlycob/cwh094. [DOI link]

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Unspecified
Substance:

Lectins (RF-00000439-ORG)
Additional substance description:

agglutinin
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Analytical method - additional description:

CAPILARRY AFFINITY ELECTROPHORESIS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

agglutinin (lectins) in bulb

Endpoint study #1: Wolf, P., Blanke, HJ., Wohlsein, P., Kamphues, J., Stober, M. Animal nutrition for veterinarians - actual cases: Tulip onions with leaves (Tulipa gesneriana) - an unusual and high-risk plant in ruminant feeding. . deutsche tierarztliche wochenschrift, 2003, vol. 110, no. 7, p. 302–305. .

Study relevance:

Human health
Plant part:

Bulb / clove (as part-nature) (A067A)
Preparation/Extraction method:

Raw, no heat treatment (A07HS)
Additional plant/substance description:

anti-nutritive substances such as lectins
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cattle (as animal) (A057E)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

14
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Stomach (TT027A)
Effect description:

Intensive mucosal irritation, accompanied by reduced feed digestion and bodyweight gains, drooling, vomiting and diarrhea; death of 14 animals out of 50
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

case report of cattle death following bulb ingestion

Genotox #1: PANKOVA, K., VELEMINSKY, J., GICHNER, T. TULIPA-GESNERIANA BULB EXTRACTS ACTIVATE PROMUTAGENIC 7,12-DIMETHYLBENZ A ANTHRACENE IN THE SALMONELLA AMES ASSAY . mutation research, 1986, vol. 174, no. 3, p. 161–164. DOI: 10.1016/0165-7992(86)90143-0. [DOI link]

Study category:

Mutagenicity
Type of toxicological test:

bacterial gene mutation assay (CHD027TT)
Method type:

in vitro
Tested organism:

Salmonella typhimurium (as organism) (A0CPZ)
Strain of test organism:

TA 98 (CHD029ST)
Control groups used:

yes
Endpoint measured:

gene mutation
Is genotoxic:

Positive
Remarks on genotox study:

Tulipa gesneriana bulbs activates promutagen DMBA; frequency of his + revertants was more than 50 times higher than the value found after the action of the promutagen alone
Internal remarks:

bulbs activate promutagen DMBA
Internal ID:

WOS:A1986D147000001