EFSA Compendium of Botanicals

Draft - work in progress

Garden nasturtium (as plant) // Tropaeolum majus L.

Family:: Tropaeolaceae
Approval state:: Approved
Number of articles retrieved:: 650
Number of processed references:: 3

Compositions

#1: glucobrassicin in seeds #2: sinigrin (glucosinolate) in flowers #3: glucosinolates in flowers

Endpoint Studies

Genotoxicity

Composition #1: Bennett, Richard N., Mellon, Fred A., Kroon, Paul A. Screening crucifer seeds as sources of specific intact glucosinolates using ion-pair high-performance liquid chromatography negative ion electrospray mass spectrometry. Journal of Agricultural and Food Chemistry, 2004, p. 428–438. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

glucobrassicin (RF-00003840-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Value (concentration, content):

traces
Internal remarks:

glucobrassicin in seeds

Composition #2: Hu, Ye., Liang, Hao., Yuan, Qipeng., Hong, Yuancheng. Determination of glucosinolates in 19 Chinese medicinal plants with spectrophotometry and high-pressure liquid chromatography. Natural Product Research, 2010, p. 1195–1205. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

deionised water
Substance:

sinigrin (RF-00004055-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Millimole/kilogram (G070A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.719
Internal remarks:

sinigrin (glucosinolate) in flowers

Composition #3: Hu, Ye., Liang, Hao., Yuan, Qipeng., Hong, Yuancheng. Determination of glucosinolates in 19 Chinese medicinal plants with spectrophotometry and high-pressure liquid chromatography. Natural Product Research, 2010, p. 1195–1205. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

deionised water
Substance:

Glucosinolates (RF-00000330-TOX)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Millimole/kilogram (G070A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.436
Internal remarks:

glucosinolates in flowers

Endpoint study #1: Botelho Lourenco Emerson Luiz., Muller Juliane Centeno., Boareto Ana Claudia., Gomes Caroline., Lourenco Ana Carolina., Dalsenter Paulo Roberto., Calloi Palozi Rhanany Alan., Lima Prando Thiago Bruno., Gasparotto Junior Arquimedes. Effects of Angiotensin-Converting Enzyme Inhibitor Derived from Tropaeolum majus L. in Rat Preimplantation Embryos: Evidence for the Dehydroepiandrosterone and Estradiol Role. evidence-based complementary and alternative medicine : ecam, 2014 . .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

90% ethanol
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Female
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

7.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

11
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

3
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

pre-implantation loss
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Significant pre-implantation losses