EFSA Compendium of Botanicals

Draft - work in progress

Trichilia catigua A.Juss.

Family:: Meliaceae
Approval state:: Approved
Number of articles retrieved:: 83
Number of processed references:: 4

Compositions

#1: lignans #2: Alkaloids #3: Tannins (bark)

Endpoint Studies

#1: Dopaminergic effect #2: Antidepressant effect, increased hippocampal cell proliferation #3: increased number of pre- and post-implantation losses

Genotoxicity

Composition #1: Dutra, Rafael C., Campos, Maria M., Santos, Adair R. S., Calixto, Joao B. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives. Pharmacological Research, 2016 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

lignans (RF-00004361-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignans

Composition #2: Dutra, Rafael C., Campos, Maria M., Santos, Adair R. S., Calixto, Joao B. Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives. Pharmacological Research, 2016 . .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids

Composition #3: dos Santos, AH., Ramos, AC., Silveira, KM., Kiss, ACI., Longhini, R., Diniz, A., de Mello, JCP., Gerardin, DCC. The exposure to Trichilia catigua (catuaba) crude extract impairs fertility of adult female rats but does not cause reproductive damage to male offspring. JOURNAL OF ETHNOPHARMACOLOGY, 2015, vol. 166, p. 86–91. DOI: 10.1016/j.jep.2015.03.018. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone and water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

HPLC-DAD (F587A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

31.43
Internal remarks:

Tannins (bark)

Endpoint study #1: Viana, Alice F., Maciel, Izaque S., Motta, Emerson M., Leal, Paulo C., Pianowski, Luiz., Campos, Maria M., Calixto, Joao B. Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects . evidence-based complementary and alternative medicine, 2011, p. 1–8. DOI: 10.1093/ecam/nep144. [DOI link]

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

EtOH-water
Type of toxicological test:

other (CHD008TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Number of organisms dosed:

20
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

200
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Brain (TT034A)
Effect description:

Decreased sensitivity to pain - dopaminergic effect
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

Dopaminergic effect

Endpoint study #2: Bonassoli, Vivian Taciany., Chassot, Janaine Micheli., Longhini, Renata., Milani, Humberto., Mello, Joao Carlos P., Weffort de Oliveira, Rubia Maria. Subchronic administration of Trichilia catigua ethyl-acetate fraction promotes antidepressant-like effects and increases hippocampal cell proliferation in mice . journal of ethnopharmacology, 2012, vol. 143, no. 1, p. 179–184. DOI: 10.1016/j.jep.2012.06.021. [DOI link]

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

aceton- water
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

15
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

400
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Brain (TT034A)
Effect description:

antidepressant effect, increased hippocampal cell proliferation
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

Antidepressant effect, increased hippocampal cell proliferation

Endpoint study #3: dos Santos, AH., Ramos, AC., Silveira, KM., Kiss, ACI., Longhini, R., Diniz, A., de Mello, JCP., Gerardin, DCC. The exposure to Trichilia catigua (catuaba) crude extract impairs fertility of adult female rats but does not cause reproductive damage to male offspring. JOURNAL OF ETHNOPHARMACOLOGY, 2015, vol. 166, p. 86–91. DOI: 10.1016/j.jep.2015.03.018. [DOI link]

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

acetone–water solution (7:3, v/v)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Female
Exposure duration:

21.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

13
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

400
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

increased number of pre- and post-implantation losses
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

increased number of pre- and post-implantation losses