EFSA Compendium of Botanicals

Draft - work in progress

Tragia involucrata L.

Family:: Euphorbiaceae
Approval state:: Approved
Number of articles retrieved:: 41
Number of processed references:: 3

Compositions

#1: Tannins (leaves) #2: Alkaloids (leaves) #3: Saponins (leaves) #4: Saponins (roots, methanol resp. water extr) #5: Alkaloids (roots, chloroform extr) #6: Tannins (roots, methanol resp. water extr)

Endpoint Studies

#1: Anti-fertility activity

Genotoxicity

Composition #1: Gobalakrishnan, R., Kulandaivelu, M., Bhuvaneswari, R., Kandavel, D., Kannan, L. Screening of wild plant species for antibacterial activity and phytochemical analysis of Tragia involucrata L.. journal of pharmaceutical analysis, 2013, vol. 3, no. 6, p. 460–465. DOI: 10.1016/j.jpha.2013.07.001. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins (leaves)

Composition #2: Gobalakrishnan, R., Kulandaivelu, M., Bhuvaneswari, R., Kandavel, D., Kannan, L. Screening of wild plant species for antibacterial activity and phytochemical analysis of Tragia involucrata L.. journal of pharmaceutical analysis, 2013, vol. 3, no. 6, p. 460–465. DOI: 10.1016/j.jpha.2013.07.001. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (leaves)

Composition #3: Gobalakrishnan, R., Kulandaivelu, M., Bhuvaneswari, R., Kandavel, D., Kannan, L. Screening of wild plant species for antibacterial activity and phytochemical analysis of Tragia involucrata L.. journal of pharmaceutical analysis, 2013, vol. 3, no. 6, p. 460–465. DOI: 10.1016/j.jpha.2013.07.001. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins (leaves)

Composition #4: Dash G K., Subburaju T., Khuntia T K., Khuntia J., Moharana S., Suresh P. Some pharmacognostical characteristics of tragia involucrata linn. Roots. ancient science of life, 2000, p. 1–5. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol, water
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins (roots, methanol resp. water extr)

Composition #5: Dash G K., Subburaju T., Khuntia T K., Khuntia J., Moharana S., Suresh P. Some pharmacognostical characteristics of tragia involucrata linn. Roots. ancient science of life, 2000, p. 1–5. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Chloroform
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (roots, chloroform extr)

Composition #6: Dash G K., Subburaju T., Khuntia T K., Khuntia J., Moharana S., Suresh P. Some pharmacognostical characteristics of tragia involucrata linn. Roots. ancient science of life, 2000, p. 1–5. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol, water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins (roots, methanol resp. water extr)

Endpoint study #1: Chandrashekhar Joshi, G., Gopal, M. Antifertility activity of hexane and ethyl acetate extracts of aerial parts of tragia involucrata. linn. journal of pharmacology and toxicology, 2011, vol. 6, no. 5, p. 548–553. DOI: 10.3923/jpt.2011.548.553. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

hexane/methanol, divided into hexane fraction, ethyl acetate fraction
Type of toxicological test:

reproduction toxicity (CHD009TT)
Limit test:

Not applicable
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

7.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

12
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

200
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

Anti-fertility activity - significant reduction of litters born; 50 - 81% antiimplantation potency; estrogenic activity
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Anti-fertility activity