EFSA Compendium of Botanicals

Draft - work in progress

Toona ciliata M.Roem. // Cedrela toona Roxb. ex Rottler

Family:: Meliaceae
Approval state:: Approved
Number of articles retrieved:: 543
Number of processed references:: 8

Compositions

#1: Scopoletin (leaves, stem) #2: Coumarins (leaves, stem) #3: Isoscopoletin (leaves, stem) #4: Lignans (lariciresinol; leaves, stem) #5: Loliolide (leaves, stem) #6: Coumarins #7: skimmianine #8: 9,10-Dihydro-phenanthrenes #9: Polyynes (leaves) #10: Toonasterone A-C and Aglawone #11: Lignans (leaves, stem) #12: Furan derivatives (leaves) #13: Estragole (leaves ess oil, quantified)

Endpoint Studies

Genotoxicity

Composition #1: Liu, Y.-B., Cheng, X.-R., Qin, J.-J., Yan, S.-K., Jin, H.-Z., Zhang, W.-D. Chemical Constituents of Toona ciliata var. pubescens. Chinese Journal of Natural Medicines, 2011, vol. 9, no. 2, p. 115–119. DOI: 10.3724/SP.J.1009.2011.00115. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Scopoletin (leaves, stem)

Composition #2: Liu, Y.-B., Cheng, X.-R., Qin, J.-J., Yan, S.-K., Jin, H.-Z., Zhang, W.-D. Chemical Constituents of Toona ciliata var. pubescens. Chinese Journal of Natural Medicines, 2011, vol. 9, no. 2, p. 115–119. DOI: 10.3724/SP.J.1009.2011.00115. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

coumarins (RF-00004351-PAR)
Additional substance description:

4, 6, 7-trimethoxy-5-methylcoumarin; 6, 7-dimethoxycoumarin; 7-hydroxy-6, 8-dime- thoxycoumarin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins (leaves, stem)

Composition #3: Liu, Y.-B., Cheng, X.-R., Qin, J.-J., Yan, S.-K., Jin, H.-Z., Zhang, W.-D. Chemical Constituents of Toona ciliata var. pubescens. Chinese Journal of Natural Medicines, 2011, vol. 9, no. 2, p. 115–119. DOI: 10.3724/SP.J.1009.2011.00115. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

Isoscopoletin (RF-00010985-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoscopoletin (leaves, stem)

Composition #4: Liu, Y.-B., Cheng, X.-R., Qin, J.-J., Yan, S.-K., Jin, H.-Z., Zhang, W.-D. Chemical Constituents of Toona ciliata var. pubescens. Chinese Journal of Natural Medicines, 2011, vol. 9, no. 2, p. 115–119. DOI: 10.3724/SP.J.1009.2011.00115. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

lariciresinol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans (lariciresinol; leaves, stem)

Composition #5: Liu, Y.-B., Cheng, X.-R., Qin, J.-J., Yan, S.-K., Jin, H.-Z., Zhang, W.-D. Chemical Constituents of Toona ciliata var. pubescens. Chinese Journal of Natural Medicines, 2011, vol. 9, no. 2, p. 115–119. DOI: 10.3724/SP.J.1009.2011.00115. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

Loliolide (RF-00011181-PAR)
Additional substance description:

benzofuran
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Loliolide (leaves, stem)

Composition #6: Chowdhury, R., Rashid, RB., Sohrab, MH., Hasan, CM. 12 alpha-hydroxystigmast-4-en-3-one: a new bioactive steroid from Toona ciliata (Meliaceae) . pharmazie, 2003, vol. 58, no. 4, p. 272–273. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

petroleum ether
Substance:

coumarins (RF-00004351-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Coumarins

Composition #7: Castro-Gamboa, I., da Silva, MFGF., Fo, ER., Fernandes, JB., Vieira, PC., Pinheiro, AL. Unusual natural 9,10-dihydrophenanthrenes from roots of Toona ciliata. ARKIVOC, 2004, p. 45–53. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, CH2Cl2, MeOH and H2O
Substance:

skimmianine (RF-00004057-PAR)
Additional substance description:

skimmianine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

skimmianine

Composition #8: Castro-Gamboa, I., da Silva, MFGF., Fo, ER., Fernandes, JB., Vieira, PC., Pinheiro, AL. Unusual natural 9,10-dihydrophenanthrenes from roots of Toona ciliata. ARKIVOC, 2004, p. 45–53. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane, CH2Cl2, MeOH and H2O
Substance:

Phenanthrenes (RF-00010826-PAR)
Additional substance description:

9,10-Dihydro-phenanthrenes
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

9,10-Dihydro-phenanthrenes

Composition #9: Ning, J., Di, YT., Li, SF., Geng, ZL., He, HP., Wang, YH., Wang, YY., Li, Y., Li, SL., Hao, XJ. Polyynes from Toona ciliata var. ciliata and Related Cytotoxic Activity. HELVETICA CHIMICA ACTA, 2011, vol. 94, no. 3, p. 376–381. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

Polyynes Polyynes (RF-00004322-PAR)
Additional substance description:

(3R,8E,10S)-Heptadec-8-ene-4,6-diyne-3,10-diol; (9S,10E,16R)-Octadec-10-ene-12,14-diyne-1,9,16-triol; (9S,10E,16R)-9,16-Dihydroxyoctadec-10-ene-12,14-diyn-1-yl Acetate
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Polyynes (leaves)

Composition #10: Wang, JR., Shen, Q., Fang, L., Peng, SY., Yang, YM., Li, J., Liu, HL., Guo, YW. Structural and stereochemical studies of five new pregnane steroids from the stem bark of Toona ciliata var. pubescens. STEROIDS, 2011, vol. 76, no. 6, p. 571–576. DOI: 10.1016/j.steroids.2011.02.007. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Phenanthrenes (RF-00010826-PAR)
Additional substance description:

Toonasterones A-C, Aglawone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Toonasterone A-C and Aglawone

Composition #11: Liu, YB., Qin, JJ., Cheng, XR., Zhu, JX., Zhang, F., Jin, HZ., Zhang, WD. Three New Neolignans and One New Phenylpropanoid from the Leaves and Stems of Toona ciliata var. pubescens. HELVETICA CHIMICA ACTA, 2011, vol. 94, no. 9, p. 1685–1691. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (95%)
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

7R,8S,7’E)-4,9-Dihydroxy-3,7,3’,9’-tetramethoxy-8,4’-oxyneolign-7’-ene; (7S,8S,7’E)-4,9-Dihydroxy-3,7,3’,9’-tetramethoxy-8,4’-oxyneolign-7’-ene; 7S,8S,7’E)-5,9-Dihydroxy-3,7,3’,5’,9’-pentamethoxy-8,4’-oxyneolign-7’-ene
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans (leaves, stem)

Composition #12: Liu, JQ., Wang, CF., Li, Y., Chen, JC., Zhou, L., Qiu, MH. Limonoids from the leaves of Toona ciliata var. yunnanensis. PHYTOCHEMISTRY, 2012, vol. 76, p. 141–149. DOI: 10.1016/j.phytochem.2012.01.002. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH (95%)
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

Toonayunnanin A, B, C, D, E, F, G, H, I, J, K, L
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Furan derivatives (leaves)

Composition #13: Duan, DM., Chen, LP., Yang, XY., Tu, Y., Jiao, S. Antidepressant-like effect of essential oil isolated from Toona ciliata Roem. var. yunnanensis. JOURNAL OF NATURAL MEDICINES, 2015, vol. 69, no. 2, p. 191–197. DOI: 10.1007/s11418-014-0878-0. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Estragole (RF-00003806-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.16
Internal remarks:

Estragole (leaves ess oil, quantified)