Draft - work in progress
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- Tinospora cordifolia (Willd.) Miers
Tinospora cordifolia (Willd.) Miers
- Family:
- Menispermaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 1242
- Number of processed references:
- 8
Compositions
#1: Aporphine alkaloids (stem; magnoflorine, isocorydine, lauriflorine, menisperine, zanthoplainine, isoboldine, boldine, chiloenamine)
#2: Jatrorrhizine (stem, quantitative)
#3: Magnoflorine (stem, quantitative)
#4: Palmatine (stem, quantitative)
#5: Tetrahydropalmatine (stem, quantitative)
#6: Isocorydine (stem, quantitative)
#7: Protoberberine alkaloids (stem; jatrorrhizine, palmatine, columbamine, stepharanine)
#8: Corydine
#9: Pregnan derivatives (quantitative)
#10: Tannins (stem)
#11: Alkaloids (stem)
#12: Saponins (stem)
#13: Isoquinoline alkaloids (stem; jatrorrhizine, magnoflorine, palmatine)
#14: Alkaloids (stem; jatrorrhizin, palmatine, magnoflorine)
#15: Furan derivative (stem)
Composition #1: Bajpai, Vikas., Singh, Awantika., Chandra, Preeti., Negi, M. P. S., Kumar, Nikhil., Kumar, Brijesh. Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT-MS/MS. Phytochemical Analysis, 2016, p. 92–99. .
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
Aporphine alkaloids (RF-00010806-PAR)
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Additional substance description:
magnoflorine, isocorydine, lauriflorine, menisperine, zanthoplainine, isoboldine, boldine, chiloenamine
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Analytical method - additional description:
HPLC-MS/MS, UPLC-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Aporphine alkaloids (stem; magnoflorine, isocorydine, lauriflorine, menisperine, zanthoplainine, isoboldine, boldine, chiloenamine)
Composition #2: Bajpai, Vikas., Singh, Awantika., Chandra, Preeti., Negi, M. P. S., Kumar, Nikhil., Kumar, Brijesh. Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT-MS/MS. Phytochemical Analysis, 2016, p. 92–99. .
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
jatrorrhizine (RF-00003887-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Analytical method - additional description:
HPLC-MS/MS, UPLC-MS
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Result unit:
Milligram/gram (G060A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.28-1.70
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Internal remarks:
Jatrorrhizine (stem, quantitative)
Composition #3: Bajpai, Vikas., Singh, Awantika., Chandra, Preeti., Negi, M. P. S., Kumar, Nikhil., Kumar, Brijesh. Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT-MS/MS. Phytochemical Analysis, 2016, p. 92–99. .
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-
Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
magnoflorine (RF-00003919-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Analytical method - additional description:
HPLC-MS/MS, UPLC-MS
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Result unit:
Milligram/gram (G060A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
3.03-7.28
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Internal remarks:
Magnoflorine (stem, quantitative)
Composition #4: Bajpai, Vikas., Singh, Awantika., Chandra, Preeti., Negi, M. P. S., Kumar, Nikhil., Kumar, Brijesh. Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT-MS/MS. Phytochemical Analysis, 2016, p. 92–99. .
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-
Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
palmatine (RF-00003971-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Analytical method - additional description:
HPLC-MS/MS, UPLC-MS
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Result unit:
Milligram/gram (G060A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
1.09-2.31
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Internal remarks:
Palmatine (stem, quantitative)
Composition #5: Bajpai, Vikas., Singh, Awantika., Chandra, Preeti., Negi, M. P. S., Kumar, Nikhil., Kumar, Brijesh. Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT-MS/MS. Phytochemical Analysis, 2016, p. 92–99. .
-
-
Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
tetrahydropalmatin (RF-00003602-PAR)
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Additional substance description:
Tetrahydropalmatine
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Analytical method - additional description:
HPLC-MS/MS, UPLC-MS
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Result unit:
Milligram/gram (G060A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.29-0.77
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Internal remarks:
Tetrahydropalmatine (stem, quantitative)
Composition #6: Bajpai, Vikas., Singh, Awantika., Chandra, Preeti., Negi, M. P. S., Kumar, Nikhil., Kumar, Brijesh. Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT-MS/MS. Phytochemical Analysis, 2016, p. 92–99. .
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
isocorydine (RF-00003443-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Analytical method - additional description:
HPLC-MS/MS, UPLC-MS
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Result unit:
Milligram/gram (G060A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.28-1.04
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Internal remarks:
Isocorydine (stem, quantitative)
Composition #7: Bajpai, Vikas., Singh, Awantika., Chandra, Preeti., Negi, M. P. S., Kumar, Nikhil., Kumar, Brijesh. Analysis of phytochemical variations in dioecious Tinospora cordifolia stems using HPLC/QTOF MS/MS and UPLC/QqQLIT-MS/MS. Phytochemical Analysis, 2016, p. 92–99. .
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-
Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
protoberberine alkaloids: jatrorrhizine, palmatine, columbamine, stepharanine
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Analytical method - additional description:
HPLC-MS/MS, UPLC-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Protoberberine alkaloids (stem; jatrorrhizine, palmatine, columbamine, stepharanine)
Composition #8: Singh, Deepika., Chaudhuri, Prabir K. (+) Corydine from the Stems of Tinospora cordifolia. asian journal of chemistry, 2015, p. 1567–1568. .
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
extd. with alc. after its defatification with hexane
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Substance:
corydine (RF-00003752-PAR)
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
2D NMR and MS analyses
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Corydine
Composition #9: Sharma, Upendra., Bala, Manju., Kumar, Praveen., Rampal, Geetanjali., Kumar, Neeraj., Singh, Bikram., Arora, Saroj. Antimutagenic extract from Tinospora cordifolia and its chemical composition . journal of medicinal plants research, 2010, vol. 4, no. 23, p. 2488–2494. .
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
hexane
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Substance:
pregnane derivatives (RF-00004313-PAR)
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Additional substance description:
Pregnan-20-one
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Analytical method code:
GC-MS (F046A)
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Result unit:
Percent (G138A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.75
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Internal remarks:
Pregnan derivatives (quantitative)
Composition #10: Sengupta, M., Sharma, GD., Chakraborty, B. Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, vol. 11 . DOI: 10.1186/1472-6882-11-102.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Substance:
Tannins (RF-00004337-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Tannins (stem)
Composition #11: Sengupta, M., Sharma, GD., Chakraborty, B. Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, vol. 11 . DOI: 10.1186/1472-6882-11-102.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
aqueous
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Substance:
Alkaloids (RF-00004360-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Alkaloids (stem)
Composition #12: Sengupta, M., Sharma, GD., Chakraborty, B. Effect of aqueous extract of Tinospora cordifolia on functions of peritoneal macrophages isolated from CCl4 intoxicated male albino mice. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, vol. 11 . DOI: 10.1186/1472-6882-11-102.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Substance:
Saponins (RF-00004333-PAR)
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Analytical method code:
Phytochemical screening (F604A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Saponins (stem)
Composition #13: Patel, MB., Mishra, SM. Magnoflorine from Tinospora cordifolia stem inhibits alpha-glucosidase and is antiglycemic in rats. JOURNAL OF FUNCTIONAL FOODS, 2012, vol. 4, no. 1, p. 79–86. DOI: 10.1016/j.jff.2011.08.002.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Methanol
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Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
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Additional substance description:
jatrorrhizine, magnoflorine, palmatine
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Analytical method code:
Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Isoquinoline alkaloids (stem; jatrorrhizine, magnoflorine, palmatine)
Composition #14: Patel, Mayurkumar B., Mishra, Shrihari. Isoquinoline Alkaloids from Tinospora cordifolia Inhibit Rat Lens Aldose Reductase . phytotherapy research, 2012, vol. 26, no. 9, p. 1342–1347. DOI: 10.1002/ptr.3721.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
MeOH
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
jatrorrhizin, palmatine, magnoflorine
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Analytical method code:
GC-MS (F046A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Alkaloids (stem; jatrorrhizin, palmatine, magnoflorine)
Composition #15: Patel, Arti., Bigoniya, Papiya., Singh, Chandra Shekhar., Patel, Narayan Singh. Radioprotective and cytoprotective activity of Tinospora cordifolia stem enriched extract containing cordifolioside-A . indian journal of pharmacology, 2013, vol. 45, no. 3, p. 237–243. DOI: 10.4103/0253-7613.111919.
[
DOI link]
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Plant part:
Stem / stalk (as part-nature) (A067S)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol
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Substance:
furan derivatives (RF-00004396-PAR)
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Additional substance description:
cordifolioside, furan glycoside
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Analytical method code:
HPLC-DAD (F587A)
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Analytical method - additional description:
GC-MS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Furan derivative (stem)
Endpoint study
#1: Ahmed, F., Islam, F., Nahar, N., Ahmed, M., Rana, A.H., Hasanur Rahman, K.M., Hossain, M.M., Rahmatullah, M. Assessment of bioactivity of Bangladeshi medicinal plants using brine shrimp lethality assay. advances in natural and applied sciences, 2012, vol. 6, no. 8, p. 1325–1329. .
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Study relevance:
Human health
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
Ethanol
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Type of toxicological test:
acute toxicity (CHD016TT)
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Limit test:
Not applicable
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Tested organism:
Brine shrimp (as animal) (A0YSQ)
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Route of exposure:
OTHER (OECD0PL)
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Unit of exposure duration:
Hour (G099A)
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Endpoint measured:
Concentration producing lethality in 50% of experimental organisms (CHD023EP)
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Concentration unit:
Microgram/millilitre (G052A)
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Effect concentration:
15.29
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Critical effect:
Other toxicities (TOX19A)
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Effect description:
LC50 brine shrimp assay
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
LC50 brine shrimp