EFSA Compendium of Botanicals

Draft - work in progress

Taxus wallichiana Zucc.

Family:: Taxaceae
Approval state:: Approved
Number of articles retrieved:: 554
Number of processed references:: 3

Compositions

#1: diterpenes #2: lignans #3: taxanes diterpenes in bark

Endpoint Studies

Genotoxicity

Composition #1: Shanker, K., Negi, A.S., Chattopadhyay, S.K., Sashidhara, K.V., Kaur, T., Gupta, M.L., Agrawal, P., Misra, A. Determination of paclitaxel, 10-DAB, and related taxoids in Himalayan yew using reverse phase HPLC. Journal of Herbs, Spices and Medicinal Plants, 2008, vol. 13, no. 4, p. 25–44. DOI: 10.1080/10496470801946000. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

Brevifoliol and derivatives, cephalomannine, 10-deacetylbaccatin III, 2-Deacetoxy-decinnamoyl taxinine-J
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

diterpenes

Composition #2: Chattopadhyay, SK., Kulshrestha, M., Tripathi, V., Saha, GC., Sharma, RP., Mehta, VK. Studies on the Himalayan yew Taxus wallichiana: Part VII - The taxoids and phenolic constituents of the roots of Taxus wallichiana. MEDICINAL CHEMISTRY, 1999, vol. 38, no. 6, p. 701–704. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

(-)seco-isolariciresinol, taxiresinol, isotaxiresinol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lignans

Composition #3: Sun, Zhang-Hua., Chen, Yu., Guo, Yan-Qiong., Qiu, Jie., Zhu, Cui-Ge., Jin, Jing., Tang, Gui-Hua., Bu, Xian-Zhang., Yin, Sheng. Isolation and cytotoxicity evaluation of taxanes from the barks of Taxus wallichiana var. mairei. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, vol. 25, no. 6, p. 1240–1243. DOI: 10.1016/j.bmcl.2015.01.056. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

15 taxanes
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

taxanes diterpenes in bark