EFSA Compendium of Botanicals

Draft - work in progress

Tabernaemontana citrifolia L.

Family:: Apocynaceae
Approval state:: Approved
Number of articles retrieved:: 11
Number of processed references:: 4

Compositions

#1: voacangine, coronaridine, and aparicine #2: alkaloids in root bark #3: alkaloids in fruits #4: alkaloids in stem bark #5: alkaloids in leaves #6: 28 indole alkaloids in leaves #7: indole alkaloids

Endpoint Studies

Genotoxicity

Composition #1: Iglesias, R., Rodriguez, M. Alkaloids from the leaves of Tabernaemontana citrifolia Linn. (Tabernaemontana alba Mill). revista cenic, ciencias fisicas, 1979, p. 351–356. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

voacangine, coronaridine, and aparicine
Analytical method code:

Element spectroscopy (F051A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

voacangine, coronaridine, and aparicine

Composition #2: Kutney, James P., Perez, Ileana. Studies on natural products from Cuban plants. Alkaloids from Tabernaemontana citrifolia. helvetica chimica acta, 1982, p. 2242–2250. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

NH40H/CH30H 1 : 2
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

6 alkaloids identified in root bark
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR+MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.5
Internal remarks:

alkaloids in root bark

Composition #3: Kutney, James P., Perez, Ileana. Studies on natural products from Cuban plants. Alkaloids from Tabernaemontana citrifolia. helvetica chimica acta, 1982, p. 2242–2250. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

NH40H/CH30H 1 : 2
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

3 alkaloids identified in fruits
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR+MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.5
Internal remarks:

alkaloids in fruits

Composition #4: Kutney, James P., Perez, Ileana. Studies on natural products from Cuban plants. Alkaloids from Tabernaemontana citrifolia. helvetica chimica acta, 1982, p. 2242–2250. .

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

NH40H/CH30H 1 : 2
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

7 alkaloids identified in stem bark
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR+MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1
Internal remarks:

alkaloids in stem bark

Composition #5: Kutney, James P., Perez, Ileana. Studies on natural products from Cuban plants. Alkaloids from Tabernaemontana citrifolia. helvetica chimica acta, 1982, p. 2242–2250. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

NH40H/CH30H 1 : 2
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

6 alkaloids identified in leaves
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR+MS
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.3
Internal remarks:

alkaloids in leaves

Composition #6: Abaul, J., Philogene, E., Bourgeois, P., Ahond, A., Poupat, C., Potier, P. Study on American Tabernaemontanas. VI. Alkaloids from the leaves of Tabernaemontana citrifolia. journal of natural products, 1989, p. 1279–1283. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

28 indole alkaloids identified
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

column chromatography
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

28 indole alkaloids in leaves

Composition #7: Rastogi, N., Abaul, J., Goh, KS., Devallois, A., Philogene, E., Bourgeois, P. Antimycobacterial activity of chemically defined natural substances from the Caribbean flora in Guadeloupe . fems immunology and medical microbiology, 1998, vol. 20, no. 4, p. 267–273. DOI: 10.1111/j.1574-695X.1998.tb01136.x. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

ibogaine and voacangine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

indole alkaloids